Understanding the pathogenesis of hip fracture in the elderly, osteoporotic theory is not reflected in the outcome of prevention programmes

Guerado, Enrique; Sandalio, Rosa M; Caracuel, Zaira; Caso, Enrique

doi:10.5312/wjo.v7.i4.218

Cited by 13 publications

(7 citation statements)

References 70 publications

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“…For that reason, there is a real need for epidemiological studies in Asia to assess the potential changes in the expected risk factors of hip fractures, to help the health administration authorities to put the proper plans and policies for the future care of those populations. It is important to know about the long term medical outcomes and how to prevent the second occurrence of hip fractures among older adults in Asia countries [8], [9], [10]. In the developed world countries, with the improvement in medical care and increased life expectancy, the hip fractures become a serious public medical problem, as the elderlies are liable for frequent falls due to generalised muscle weakness and many types of walking disabilities.…”

Section: Importance Of the Studymentioning

confidence: 99%

“…Although most of the older adults are osteoporotic but that is alone does not result in hip fracture without sustaining a trauma, so if we plan to decrease the rate of incidence of hip fractures we need to study the two aspects of the problem, the medical and social aspects of the problem for any policy of the hip fracture prevention to be successful [9]…”

Section: Importance Of the Studymentioning

confidence: 99%

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Risk Factors Associated With Hip Fractures among Adult People in Babylon City, Iraq

Al-Algawy

Baiee

Hasan

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: The fractures of hip joint considered as a serious problem in public health in the medical and socioeconomic issues, the incidence of the fracture neck femur is significantly increased with the increment of general population life span. AIM: The goal of this study is to highlight and focus on the most important risk factor for the hip fractures in our Babylon society, and to improve our understanding of the medical and social aspects of these predisposing factors. PATIENTS AND METHODS: A case-control study of older adults (above 60 years old). The study was done on tow samples. First, one consisting of 75 cases those having fracture neck femur considered as cases, and second sample as a control group, consisting of 150 people as a healthy control group having no fracture. A pre-tested questionnaire was prepared to collect data from both samples; the questionnaire included demographic data and information about potential risk factors of hip fracture. RESULTS: Most of the people in the study samples in both groups were, married women, housekeepers, illiterate and from urban dwellers. There was highly significant association between case-control groups regarding, Continuous using of medication such as cortisone which was found to be a potential risk factor of hip fracture (Unadjusted OR = 3.636), low income was positively associated risk factor of hip fracture in this study (OR = 2.377), low milk intake, low sun exposure, tobacco smoking were positively associated with this health problem (OR = 1.794), while physical exercise was protective factor (OR = 0.489). CONCLUSION: The highest risk factors associated with increased occurrence of hip fracture were using cortisone, Osteoporosis, tobacco smoking, consuming soft drinks, and less exposure to sunlight.

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Section: Importance Of the Studymentioning

confidence: 99%

Section: Importance Of the Studymentioning

confidence: 99%

Risk Factors Associated With Hip Fractures among Adult People in Babylon City, Iraq

Al-Algawy

Baiee

Hasan

et al. 2019

Open Access Maced J Med Sci

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“…Secondly, our model did not account for spontaneous fractures and, therefore, it might underestimate the total number of SHFs. However, we anticipate this assumption is unlikely to have a material impact on our estimates since we simulated populations highly prone to fall [ 26 ]. Thirdly, we acknowledge that a meta-analysis of the HRQOL utilities, accounting for either CCI or the included comorbidities, would have been the ideal approach.…”

Section: Discussionmentioning

confidence: 99%

Determining the cost-effectiveness requirements of an exoskeleton preventing second hip fractures using value of information

Manetti

Turchetti²,

Fusco

2020

BMC Health Serv Res

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Background Falls may lead to hip fractures, which have a detrimental effect on the prognosis of patients as well as a considerable impact on healthcare expenditures. Since a secondary hip fracture (SHF) may lead to even higher costs than primary fractures, the development of innovative services is crucial to limit falls and curb costs in high-risk patients. An early economic evaluation assessed which patients with a second hip fracture could benefit most from an exoskeleton preventing falls and whether its development is feasible. Methods The life-course of hip fractured patients presenting with dementia or cardiovascular diseases was simulated using a Markov model relying on the United Kingdom administrative data and complemented by published literature. A group of experts provided the exoskeleton parameters. Secondary analyses included a threshold analysis to identify the exoskeleton requirements (e.g. minimum impact of the exoskeleton on patients’ quality of life) leading to a reimbursable incremental cost-effectiveness ratio. Similarly, the uncertainty around these requirements was modelled by varying their standard errors and represented alongside population Expected Value of Perfect Information (EVPI). Results Our base-case found the exoskeleton cost-effective when providing a statistically significant reduction in SHF risk. The secondary analyses identified 286 cost-effective combinations of the exoskeleton requirements. The uncertainty around these requirements was explored producing further 22,880 scenarios, which showed that this significant reduction in SHF risk was not necessary to support the exoskeleton adoption in clinical practice. Conversely, a significant improvement in women quality of life was crucial to obtain an acceptable population EVPI regardless of the cost of the exoskeleton. Conclusions Our study identified the exoskeleton requisites to be cost-effective and the value of future research. Decision-makers could use our analyses to assess not only whether the exoskeleton could be cost-effective but also how much further research and development of the exoskeleton is worth to be pursued.

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“…Hip fracture, the most common osteoporosis-related complication, is a significant health problem leading to a decrease in life expectancy, disability, and mortality in the elderly population [ 53 ]. In this study, we found that the risk was correspondingly lower when we specifically focused on the risk of overall hip fracture.…”

Section: Discussionmentioning

confidence: 99%

Effects of β-Cryptoxanthin on Improvement in Osteoporosis Risk: A Systematic Review and Meta-Analysis of Observational Studies

Kim

Anh

Diem

et al. 2021

Foods

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Many studies have analyzed the effects of β-cryptoxanthin (BCX) on osteoporosis and bone health. This systematic review and meta-analysis aimed at providing quantitative evidence for the effects of BCX on osteoporosis. Publications were selected and retrieved from three databases and carefully screened to evaluate their eligibility. Data from the final 15 eligible studies were extracted and uniformly summarized. Among the 15 studies, seven including 100,496 individuals provided information for the meta-analysis. A random effects model was applied to integrate the odds ratio (OR) to compare the risk of osteoporosis and osteoporosis-related complications between the groups with high and low intake of BCX. A high intake of BCX was significantly correlated with a reduced risk of osteoporosis (OR = 0.79, 95% confidence interval (CI) 0.70–0.90, p = 0.0002). The results remained significant when patients were stratified into male and female subgroups as well as Western and Asian cohorts. A high intake of BCX was also negatively associated with the incidence of hip fracture (OR = 0.71, 95% CI 0.54–0.94, p = 0.02). The results indicate that BCX intake potentially reduces the risk of osteoporosis and hip fracture. Further longitudinal studies are needed to validate the causality of current findings.

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Understanding the pathogenesis of hip fracture in the elderly, osteoporotic theory is not reflected in the outcome of prevention programmes

Abstract: Hip fractures are an acute and worsening public health problem.

Cited by 13 publications

References 70 publications

Risk Factors Associated With Hip Fractures among Adult People in Babylon City, Iraq

Risk Factors Associated With Hip Fractures among Adult People in Babylon City, Iraq

Determining the cost-effectiveness requirements of an exoskeleton preventing second hip fractures using value of information

Effects of β-Cryptoxanthin on Improvement in Osteoporosis Risk: A Systematic Review and Meta-Analysis of Observational Studies

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