Understanding the omicron variant (B.1.1.529) of SARS-CoV-2: Mutational impacts, concerns, and the possible solutions

Islam, Fahadul; Dhawan, Manish; Nafady, Mohamed H.; Emran, Talha Bin; Mitra, Saikat; Choudhary, Om Prakash; Akter, Aklima

doi:10.1016/j.amsu.2022.103737

Cited by 41 publications

(42 citation statements)

References 73 publications

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“…L452R and F486V were unique to the BA.4 sub-lineage. Most Omicron sub-lineages had more RBD mutations than the initial Omicron variant, B.1.1.529 which consisted of 15 RBD mutations, namely G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y and Y505H [96] , [97] . Mutations K417N, G446S, N501Y and Y505H are in residues that form part of the RBD-ACE2 interface and interact with residues in sub-domain I of hACE2 ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

Barozi

Edkins²,

Bishop³

2022

Computational and Structural Biotechnology Journal

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Section: Resultsmentioning

confidence: 99%

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

Barozi

Edkins²,

Bishop³

2022

Computational and Structural Biotechnology Journal

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“…Omicron is a variant that was firstly reported in Botswana and shortly after in South Africa, in November 2021. The variant harbors over 30 mutations in the spike protein, which are related to enhanced transmissibility and reduced susceptibility to neutralizing antibodies [ 7 ]. Therefore, Omicron contributed to the majority of SARS-CoV-2 infections in many countries, posing a severe threat to global health care systems [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

Kim

Sung

Lee

et al. 2022

Viruses

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Rapid antigen tests (RATs) for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are widely used in the Coronavirus disease 2019 (COVID-19) pandemic caused by diverse variants. Information on the real-world performance of RATs for variants is urgently needed for decision makers. Systematic searches of the available literature and updates were conducted in PubMed, Ovid-MEDLINE, Ovid-EMBASE, CENTRAL, and KMBASE for articles evaluating the accuracy of instrument-free RATs for variants up until 14 March 2022. A bivariate random effects model was utilized to calculate pooled diagnostic values in comparison with real-time reverse transcription-polymerase chain reaction as the reference test. A total of 7562 samples from six studies were available for the meta-analysis. The overall pooled sensitivity and specificity of RATs for variants were 69.7% (95% confidence interval [CI] = 62.5% to 76.1%) and 100.0% (95% CI = 98.8% to 100.0%), respectively. When an additional 2179 samples from seven studies reporting sensitivities only were assessed, the pooled sensitivity dropped to 50.0% (95% CI = 44.0% to 55.0%). These findings suggest reassessment and monitoring of the diagnostic utility of RATs for variants, especially for the sensitivity aspect, to facilitate appropriate diagnosis and management of COVID-19 patients.

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“…In Figure 1 shows some variants and their clade, and all VOCs [11]. According [15][16]. The specific changes in the S protein (mutations in RBD, and N-terminal), make it more transmissible, even among vaccinated people 15, as studies demonstrated that mutations in RBD are responsible for the escape from neutralized antibodies induced by vaccine [17].…”

Section: Variantsmentioning

confidence: 99%

“…The risk of hospitalization is less than that of the Delta variant. Vaccination, especial the booster, can significantly reduce the rate of being hospitalized and the rate of fatality [15].…”

Section: Variantsmentioning

confidence: 99%

"Sars-Cov-2, Its Variants, and the Impact of Pandemic on Adolescent Mental Health"

Huang

2022

BJSTR

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The ongoing pandemic, caused by SARS-CoV-2, has dramatically impacted the world for the past two and a half years. Much effort has been focused on the prevention and treatment of this disease, along with the emergence of dominant variants. Here, we review the progress of current research on this virus and its variants, with a focus on the new Omicron variant. With the recent lockdowns in areas like Shanghai, attention needs to be paid to the psychological impact of the pandemic on the residents, especially adolescents.to the family Coronaviridae within the order Nidovirales. They

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Understanding the omicron variant (B.1.1.529) of SARS-CoV-2: Mutational impacts, concerns, and the possible solutions

Cited by 41 publications

References 73 publications

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

Evolutionary progression of collective mutations in Omicron sub-lineages towards efficient RBD-hACE2: Allosteric communications between and within viral and human proteins

Clinical Performance of Rapid and Point-of-Care Antigen Tests for SARS-CoV-2 Variants of Concern: A Living Systematic Review and Meta-Analysis

"Sars-Cov-2, Its Variants, and the Impact of Pandemic on Adolescent Mental Health"

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