Understanding the metal free alginate gelation process

Ursini, Ornella; Angelini, Roberta; Franco, Silvia; Cortese, Barbara

doi:10.1039/d1ra06599h

Cited by 6 publications

(2 citation statements)

References 29 publications

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“…The concentration of Ca 2+ ions, as well as the crosslinking time, influence the crosslinking degree [35]. When the crosslinking is fully achieved, the hydrogel becomes more rigid, its Young modulus increases, and a lower elongation capacity affects its tensile strength [36]. The degree of crosslinking not only affects the mechanical behavior of the film, but also its water resistance and swelling behavior.…”

Section: Effect Of Crosslinking On the Swelling Behavior Of The 2d An...mentioning

confidence: 99%

“…For wound healing materials, hydrophilicity in dressings is important since it allows for the absorption and evaporation of wound exudates, helping to minimize bacterial contamination. AL is inherently hydrophilic, making it suitable for use in posttraumatic wounds or those with exudate [8,34,36,41]. In both 2D and 3D structured films, those made of AL displayed the highest contact angles (less hydrophilic), while films containing only AVG were more hydrophilic, with the lowest contact angles (around 20 • ).…”

Section: Surface Wettability Of Al-avg Membranesmentioning

confidence: 99%

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Three-Dimensional Membranes of Natural Polymer Complex Nanoparticle for Potential Medical Applications

Elgegren,

Nakamatsu,

Galarreta

et al. 2023

Gels

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Skin wound healing is a complex biological process of tissue regeneration in which the wound dressing is crucial for rapid healing; it must protect the wound keep an adequate level of moisture and prevent infections. Alginate (AL), a polysaccharide from brown algae, has been extensively studied for wound treatment, and aloe vera gels (AVGs) have also been used in the treatment of skin. The AVG main bioactive polysaccharide was combined with AL for the preparation of membranes. Two-dimensional membranes were prepared by casting and, for comparison, transparent nanoparticle 3D membranes were produced by high-intensity ultrasonication followed by ionotropic crosslinking. The effects of the amount of AVG, ionotropic gelation, and the structure (2D or 3D) of the AL-AVG membranes were compared. Scanning electron microscopy (SEM) showed higher surface roughness on 3D membranes. Three-dimensional membranes showed a higher swelling ratio, and swelling increased with AVG content and decreased with higher calcium concentration and longer gelation times. The degradation of the membranes was evaluated with and without a lysozyme at pH 5.5, 7.5, and 8.5, to simulate different skin conditions; the results evidence that pH had a higher effect than the enzyme. The cytotoxicity of the membranes was evaluated with ATCC CCL 163 and ATCC CCL 81 cells, and an excellent biocompatibility of both cell types (>90% of cell viability after 48 h incubation) was observed for all AL-AVG membranes.

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Section: Effect Of Crosslinking On the Swelling Behavior Of The 2d An...mentioning

confidence: 99%