Understanding the impact of crosslinked PCL/PEG/GelMA electrospun nanofibers on bactericidal activity

De-Paula, Mirian Michelle Machado; Ghannadian, Paria; Afewerki, Samson; Marciano, Fernanda Roberta; Viana, Bartolomeu C.; Harb, Samarah Vargas; Bassous, Nicole; Webster, Thomas J.; Lobo, Anderson Oliveira

doi:10.1101/322321

Cited by 4 publications

(1 citation statement)

References 64 publications

(46 reference statements)

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“…Polycaprolactone (PCL) is one of the most used polymers in biomedical applications due to its biodegradability and biocompatibility (De Paula et al, 2018). Recent studies have explored PCL fibres as loading matrices for CuONPs (average size 35 nm) against fungi components of oral candidiasis: C .…”

Section: Fungicide Addition To Polymersmentioning

confidence: 99%

Antifungal polymers for medical applications

Velazco‐Medel¹,

Camacho‐Cruz²,

Lugo-González³

et al. 2020

Med Devices & Sens

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The application of polymers as medical devices has steadily increased in almost all medical fields because of the versatility of these materials. Thus, research has focused both on the development of more appropriate materials for specific situations and on the modification of already useful materials for the improvement of their intrinsic properties. Modifications on this kind of materials have increased their potential uses by adapting their mechanical properties to specific needs. Moreover, biocompatibility of the polymeric materials has been improved by the inclusion of certain functional groups, providing responses to physical and chemical stimuli present in physiological conditions.Until recently, one of the most worrying problems in hospitals has been infections derived from medical devices usage. Typically, this kind of infections was handled with the use of prophylactic and therapeutic treatments with 'classic' (low-molecular weight) antimicrobial agents. This strategy has been effective in most patients suffering from nosocomial infections. However, it has the disadvantage of substantially increasing the probability of antimicrobial-resistant pathogens appearance, which continue to be especially dangerous in hospital environments (Cohen et al., 2017; World Health Organization, n.d.;Zegers et al., 2017). Additionally, due to

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Section: Fungicide Addition To Polymersmentioning

confidence: 99%

Antifungal polymers for medical applications

Velazco‐Medel¹,

Camacho‐Cruz²,

Lugo-González³

et al. 2020

Med Devices & Sens

View full text Add to dashboard Cite

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Synthetic-based blended electrospun scaffolds in tissue engineering applications

2022

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Hydrogel-Impregnated Self-Oxygenating Electrospun Scaffolds for Bone Tissue Engineering

2023

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Bone defects resulting from trauma, disease, or aging present significant challenges in the clinic. Although biomaterial scaffolds for bone-tissue engineering have shown promising results, challenges remain, including the need for adequate mechanical strength and suitable bioactive agents within scaffolds to promote bone formation. Oxygen is a critical factor for successful bone formation, and low oxygen tension inhibits it. In this study, we developed gelatin methacryloyl (GelMA) hydrogel-impregnated electrospun polycaprolactone (PCL) scaffolds that can release oxygen over 3 weeks. We investigated the potential of composite scaffolds for cell survival in bone-tissue engineering. Our results showed that the addition of an increased amount of CaO2 nanoparticles to the PCL scaffolds significantly increased oxygen generation, which was modulated by GelMA impregnation. Moreover, the resulting scaffolds showed improved cytocompatibility, pre-osteoblast adhesion, and proliferation under hypoxic conditions. This finding is particularly relevant since hypoxia is a prevalent feature in various bone diseases. In addition to providing oxygen, CaO2 nanoparticles also act as reinforcing agents improving the mechanical property of the scaffolds, while the incorporation of GelMA enhances cell adhesion and proliferation properties. Overall, our newly developed self-oxygenating composite biomaterials are promising scaffolds for bone-tissue engineering applications.

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Understanding the impact of crosslinked PCL/PEG/GelMA electrospun nanofibers on bactericidal activity

Cited by 4 publications

References 64 publications

Antifungal polymers for medical applications

Antifungal polymers for medical applications

Synthetic-based blended electrospun scaffolds in tissue engineering applications

Hydrogel-Impregnated Self-Oxygenating Electrospun Scaffolds for Bone Tissue Engineering

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