Synthetic-based blended electrospun scaffolds in tissue engineering applications

Mohammadalizadeh, Zahra; Bahremandi-Toloue, Elahe; Karbasi, Saeed

doi:10.1007/s10853-021-06826-w

Cited by 47 publications

(19 citation statements)

References 233 publications

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“…With the disadvantage of hydrophobicity, PCL has poor wettability, low cell adhesion, and a slow degradation rate [29]. The poor mechanical properties and hydrophilicity of PLA impair cell adhesion and differentiation [30]. PHB has insufficient cell affinity, which may accompany some limitations [30].…”

Section: Introductionmentioning

confidence: 99%

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Cross-Linked Gamma Polyglutamic Acid/Human Hair Keratin Electrospun Nanofibrous Scaffolds with Excellent Biocompatibility and Biodegradability

et al. 2022

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Recently, human hair keratin has been widely studied and applied in clinical fields due to its good histocompatibility, biocompatibility, and biodegradability. However, the regenerated keratin from human hair cannot be electrospun alone because of its low molecular weight. Herein, gamma polyglutamic acid (γ-PGA) was first selected to fabricate smooth and uniform γ-PGA/keratin composite scaffolds with excellent biocompatibility and biodegradability by electrospinning technology and a chemical cross-linking method in this study. The effect of electrospinning parameters on the structure and morphology, the mechanism of chemical cross-linking, biocompatibility in vitro cell culture experiments, and biodegradability in phosphate-buffered saline buffer solution and trypsin solution of the γ-PGA/keratin electrospun nanofibrous scaffolds (ENS) was studied. The results show that the cross-linked γ-PGA/keratin ENSs had excellent water stability and biodegradability. The γ-PGA/keratin ENSs showed better biocompatibility in promoting cell adhesion and cell growth compared with the γ-PGA ENSs. It is expected that γ-PGA/keratin ENSs will be easily and significantly used in tissue engineering to repair or regenerate materials.

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Section: Introductionmentioning

confidence: 99%

“…The poor mechanical properties and hydrophilicity of PLA impair cell adhesion and differentiation [30]. PHB has insufficient cell affinity, which may accompany some limitations [30]. Therefore, it is necessary to use a biocompatible polymer with good hydrophilicity to further improve the biocompatibility of keratin/polymer scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Cross-Linked Gamma Polyglutamic Acid/Human Hair Keratin Electrospun Nanofibrous Scaffolds with Excellent Biocompatibility and Biodegradability

et al. 2022

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“…Electrospun nanobers have the advantages of high specic surface area, high porosity, small size and surface effect, and the three-dimensional structure similar to the extracellular matrix, 27,[37][38][39][40] which can be used for the adhesion, proliferation, growth and differentiation of host cells in vitro or in vivo as well as provide an ideal microenvironment for intercellular communication. 41,42 Moreover, the high-performing composite nanobers can be prepared using natural polymer materials with good bioactivity and synthetic polymer materials with good mechanical properties via electrospinning, which provides a facile method for the preparation of nanober scaffolds with good bioactivity and functionality. 43,44 However, there are still many problems and challenges in how to better control the microstructure, mechanical properties and functions of composite nanobers.…”

Section: Resultsmentioning

confidence: 99%

PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

et al. 2022

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“…Synthetic polymers offer higher reproducibility and control regarding mechanical properties. Importantly, they can be tailored to meet the requirements of certain applications [ 58 ]. Natural polymers, on the other hand, possess the suitable biochemical cues for cell attachment and proliferation and their degradation by-products are non-toxic.…”

Section: Use Of Electrospinning In the Development Of Kidney Tissuesmentioning

confidence: 99%

A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering

et al. 2022

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Chronic kidney disease is one of the deadliest diseases globally and treatment methods are still insufficient, relying mostly on transplantation and dialysis. Engineering of kidney tissues in vitro from induced pluripotent stem cells (iPSCs) could provide a solution to this medical need by restoring the function of damaged kidneys. However, implementation of such approaches is still challenging to achieve due to the complexity of mature kidneys in vivo. Several strategies have been defined to obtain kidney progenitor endothelial and epithelial cells that could form nephrons and proximal tube cells, but these lack tissue maturity and vascularisation to be further implemented. Electrospinning is a technique that has shown promise in the development of physiological microenvironments of several tissues and could be applied in the engineering of kidney tissues. Synthetic polymers such as polycaprolactone, polylactic acid, and poly(vinyl alcohol) have been explored in the manufacturing of fibres that align and promote the proliferation and cell-to-cell interactions of kidney cells. Natural polymers including silk fibroin and decellularised extracellular matrix have also been explored alone and in combination with synthetic polymers promoting the differentiation of podocytes and tubular-specific cells. Despite these attempts, further work is still required to advance the applications of electrospun fibres in kidney tissue engineering and explore this technique in combination with other manufacturing methods such as bioprinting to develop more organised, mature and reproducible kidney organoids.

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Synthetic-based blended electrospun scaffolds in tissue engineering applications

Cited by 47 publications

References 233 publications

Cross-Linked Gamma Polyglutamic Acid/Human Hair Keratin Electrospun Nanofibrous Scaffolds with Excellent Biocompatibility and Biodegradability

Cross-Linked Gamma Polyglutamic Acid/Human Hair Keratin Electrospun Nanofibrous Scaffolds with Excellent Biocompatibility and Biodegradability

PBAT/gelatin hybrid nanofibers based on post-double network bond processing as a promising vascular substitute

A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering

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