Understanding the Effects of Repetitive Transcranial Magnetic Stimulation on Neuronal Circuits

Matheson, Natalie A.; Shemmell, Jonathan; Ridder, Dirk De; Reynolds, John N. J.

doi:10.3389/fncir.2016.00067

Cited by 24 publications

(16 citation statements)

References 22 publications

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“…Overall, these variable findings may be due to different patient characteristics, stimulation protocols, and/or stimulation locations among studies. Furthermore, the effects of rTMS on neural activity depend on factors such as coil orientation, stimulation intensity, and brain activation [57]. For example, the TMS-related effect has been linked to the total number of stimuli, whereby a profound change in cortical excitability was observed for longer periods of rTMS [58].…”

Section: Discussionmentioning

confidence: 99%

Intermittent theta burst stimulation enhances upper limb motor function in patients with chronic stroke: a pilot randomized controlled trial

et al. 2019

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Background Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. However, only limited studies have examined its efficacy in patients with chronic stroke and therefore it remains controversial. Methods This was a randomized controlled trial that enrolled patients from a rehabilitation department. Twenty-two patients with first-ever chronic and unilateral cerebral stroke, aged 30–70 years, were randomly assigned to the iTBS or control group. All patients received 1 session per day for 10 days of either iTBS or sham stimulation over the ipsilesional primary motor cortex in addition to conventional neurorehabilitation. Outcome measures were assessed before and immediately after the intervention period: Modified Ashworth Scale (MAS), Fugl-Meyer Assessment Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), Box and Block test (BBT), and Motor Activity Log (MAL). Analysis of covariance was adopted to compare the treatment effects between groups. Results The iTBS group had greater improvement in the MAS and FMA than the control group ( η 2 = 0.151–0.233; p < 0.05), as well as in the ARAT and BBT ( η 2 = 0.161–0.460; p < 0.05) with large effect size. Both groups showed an improvement in the BBT, and there were no significant between-group differences in MAL changes. Conclusions The iTBS induced greater gains in spasticity decrease and UL function improvement, especially in fine motor function, than sham TBS. This is a promising finding because patients with chronic stroke have a relatively low potential for fine motor function recovery. Overall, iTBS may be a beneficial adjunct therapy to neurorehabilitation for enhancing UL function. Further larger-scale study is warranted to confirm the findings and its long-term effect. Trial registration This trial was registered under ClinicalTrials.gov ID No. NCT01947413 on September 20, 2013.

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Section: Discussionmentioning

confidence: 99%

Intermittent theta burst stimulation enhances upper limb motor function in patients with chronic stroke: a pilot randomized controlled trial

et al. 2019

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“…Repetitive transcranial magnetic stimulation (rTMS) is widely used for the treatment of central nervous system (CNS) diseases and is based on the regulation of brain plasticity and electromagnetic induction (Matheson et al, 2016). The effects of rTMS are determined by various stimulatory parameters including stimulus intensity, stimulus frequency, and stimulus patterns.…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Mediates Autophagy Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin Signaling

et al. 2019

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“…1 Dihipotesiskan penggunaan rTMS pascastroke dapat meningkatkan induksi plastisitas di dalam otak dan bila dikombinasikan dengan terapi manual, dapat memfasilitasi neuron yang bertahan dari fungsinya yang hilang akibat stroke. 3 Claflin dkk menemukan bahwa rTMS frekuensi rendah akan mengurangi aktivitas neuron kortikal dan rTMS frekuensi tinggi akan meningkatkan eksitabilitas neuron. [4][5] Meningkatnya jumlah pasien stroke iskemik yang mengalami gangguan memori serta proses rehabilitasi yang lama menyebabkan dibutuhkannya suatu inovasi yang saling menguatkan antara terapi yang sudah ada (terapi medik) dan stimulasi noninvasif rehabilitasi kognitif berupa rTMS.…”

Section: Pendahuluanunclassified

Pengaruh Repetitive Transcranial Magnetic Stimulation (Rtms) Terhadap Gangguan Fungsi Kognitif Pascastroke Iskemik

Azis

Tammasse

Muis

2020

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THE INFLUENCE OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) TOWARDS IMPAIRED COGNITIVE FUNCTION AFTER ISCHEMIC STROKEABSTRACTIntroduction: The increasing number of ischemic stroke patients who experience memory disturbances and a long rehabilitation process requires an innovation that can strengthen both existing therapies (medical therapy) and non-invasive stimulation of cognitive rehabilitation in the form of repetitive transcranial magnetic stimulation (rTMS).Aim: To determine effectiveness of rTMS towards impaired cognitive function in ischemic stroke.Methods: This research was conducted using experimental with open clinical trial test method on ischemic stroke patients suffering from cognitive impairment at Wahidin Sudirohusodo Hospital and Inggit Clinic, Makassar, from November 2018 until January 2019. Samples were divided into control who was given only medical therapy and treatment group who was given medical therapy and rTMS. Stimulation is given in the form of a high frequency of 10Hz in 2 cycles for 5 consecutive days with a gap of 2 days. MoCA-Ina was used to assess cognitive impairment. The assessment were made on day-1 before therapy and day-15 after therapy. The statistical analysis of correlation among variables was conducted by using Chi-square test with value of p <0.05 which was considered significant.Results: There were 22 samples, 11 in each group. The difference of MoCA-Ina scores in both groups with the final average after 15 days of treatment was 5.27 in the treatment group and 1.45 in control group. This difference is considered significant with the p value of 0.003.Discussion: There was an effect of rTMS therapy on cognitive function disorders after ischemic stroke, in which the change was greater in the treatment group than in the control group.Keywords: Cognitive impairment, ischemic stroke, Montreal Cognitive Assesment Indonesian Version (MoCA-Ina), repetitive transcranial magnetic stimulation (rTMS)ABSTRAKPendahuluan: Peningkatan jumlah pasien stroke iskemik yang mengalami gangguan memori serta proses rehabilitasi yang lama membutuhkan suatu inovasi yang dapat saling menguatkan antara terapi yang sudah ada (terapi medik) dan stimulasi non-invasif rehabilitasi kognitif berupa repetitive transcranial magnetic stimulation (rTMS).Tujuan: Mengetahui pengaruh intervensi rTMS terhadap fungsi kognitif pascastroke iskemik.Metode: Penelitian eksperimental dengan uji klinis terbuka terhadap pasien stroke iskemik yang menderita gangguan fungsi kognitif di RSUP Dr. Wahidin Sudirohusodo dan Klinik Inggit Medika, Makassar, pada bulan November 2018 hingga Januari 2019. Subjek dibagi ke dalam kelompok kontrol yang diberikan terapi medikamentosa saja serta kelompok perlakuan yang diberikan terapi medikamentosa dan intervensi rTMS. Stimulasi diberikan berupa frekuensi tinggi 10Hz dalam 2 siklus selama 5 hari berturut-turut dengan jeda waktu 2 hari. Penilaian gangguan kognitif menggunakan Montreal Cognitive Assesment versi Indonesia (MoCA-Ina). Pengukuran dilakukan pada hari-1 pre-terapi dan hari ke-15 pascaterapi. Data dianalisis secara statistik menggunakan uji Chi-square dengan nilai p<0,05 dianggap bermakna.Hasil: Terdapat 22 subjek yang masing-masing terdiri dari 11 subjek pada kelompok kontrol dan perlakuan. Selisih skor MoCA-Ina pada kedua kelompok dengan rerata akhir setelah lima belas hari perlakuan sebesar 5,27 pada kelompok perlakuan dan 1,45 pada kelompok kontrol yang bermakna (p=0,003).Diskusi: Terdapat pengaruh terapi rTMS terhadap gangguan fungsi kognitif pascastroke yang lebih besar pada kelompok perlakuan dibanding kelompok kontrol.Kata kunci: Gangguan kognitif, Montreal Cognitive Assesment versi Indonesia (MoCA-Ina), repetitive transcranial magnetic stimulation (rTMS), stroke iskemik

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Understanding the Effects of Repetitive Transcranial Magnetic Stimulation on Neuronal Circuits

Cited by 24 publications

References 22 publications

Intermittent theta burst stimulation enhances upper limb motor function in patients with chronic stroke: a pilot randomized controlled trial

Intermittent theta burst stimulation enhances upper limb motor function in patients with chronic stroke: a pilot randomized controlled trial

High-Frequency Repetitive Transcranial Magnetic Stimulation Mediates Autophagy Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin Signaling

Pengaruh Repetitive Transcranial Magnetic Stimulation (Rtms) Terhadap Gangguan Fungsi Kognitif Pascastroke Iskemik

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