High-Frequency Repetitive Transcranial Magnetic Stimulation Mediates Autophagy Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin Signaling

Wang, Xinlong; Zhou, Xing; Bao, Jie; Chen, Zhiguo; Tang, Jingzhao; Gong, Xueyang; Ni, Jing; Fang, Qi; Liu, Yaobo; Shu, Min

doi:10.3389/fnins.2019.01225

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…Many researches claimed that magnetic force and stimulation might increase growth factor secretion after nerve injury. 37,38 In this study, we similarly noted that some neural marker levels were upregulated, and the findings indicated that remyelination The sufficient regeneration of nerves and end plate organs requires adequate supply of nutrients, primarily from surrounding vessels and intraneural microvessels. We also evaluated some vascular markers, such as vascular endothelial growth factor (VEGF) and CD34.…”

supporting

confidence: 59%

“…The results strengthened previous findings that intrinsic magnetized nanoparticle scaffolds could promote extension of the neurofilament and outgrowth of the axons in the middle parts for regeneration (Figure f–h). Many researches claimed that magnetic force and stimulation might increase growth factor secretion after nerve injury. , In this study, we similarly noted that some neural marker levels were upregulated, and the findings indicated that remyelination and axonal regeneration were efficiently improved by the implantation of magnetized scaffolds in the defected nerve area.…”

supporting

confidence: 55%

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Gradient Nanoaggregation in a Magnetically Actuated Scaffold for Multiscale Immunoregulation and Microenvironment Remodeling Accelerates Nerve and Muscle Repair

Qian

Yan

Li³

et al. 2023

ACS Materials Lett.

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Biophysical cues are important additive considerations in smart degradable implants apart from chemical modification in tissue engineering. Similar with electrical and ultrasonic stimulation, intrinsic magnetic actuation in integrated implants of iron oxide nanoparticles and topological structures affects cell fate decision to enhance tissue injury repair. It also saves the trouble of carrying an external stimulator to better suit clinical and daily use. In this study, a gradient magnetized iron oxide nanoparticle scaffold (GIONS) is designed using 3D multilayered method. It has a high magnetic saturation with nanoaggregation of iron oxide nanoparticles and is featured with evenly distributed micropores and multilayer structure to realize moderate elasticity and mechanical stability. GIONS facilitates directed growth and protuberance extension of neurons and immunoregulates pro-regenerative polarization of macrophages. In a rat nerve defect injury model, GIONS successfully improves remyelination and axon sprouting in the regenerated region, and activates reparative microenvironment by stimulating neurogenesis, angiogenesis and reducing muscle atrophy. It further facilitates glial cell activation and macrophage immunoregulation in vivo by mechanochemical signaling to significantly accelerate the repair of different severed tissues. Consequently, this smart implant increases nerve conducting velocity and locomotor function and contributes to multifunctional regeneration of severe tissue injury.

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supporting

confidence: 59%

supporting

confidence: 55%

Gradient Nanoaggregation in a Magnetically Actuated Scaffold for Multiscale Immunoregulation and Microenvironment Remodeling Accelerates Nerve and Muscle Repair

Qian

Yan

Li³

et al. 2023

ACS Materials Lett.

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“…mTOR Signaling: The mammalian target of the rapamycin (mTOR) pathway is involved in regulating protein synthesis and cellular homeostasis. TMS has been associated with changes in mTOR signaling [ 79 ]. Inflammatory pathways: TMS-induced changes in neural activity may have downstream effects on inflammatory pathways involving cytokines and microglial activation [ 80 ].…”

Section: Basic Theory Of Transcranial Magnetic Stimulationmentioning

confidence: 99%

The Use of Transcranial Magnetic Stimulation in Attention Optimization Research: A Review from Basic Theory to Findings in Attention-Deficit/Hyperactivity Disorder and Depression

Yen,

Valentine,

Chiang

2024

Life

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This review explores the pivotal role of attention in everyday life, emphasizing the significance of studying attention-related brain functions. We delve into the development of methodologies for investigating attention and highlight the crucial role of brain neuroimaging and transcranial magnetic stimulation (TMS) in advancing attention research. Attention optimization theory is introduced to elucidate the neural basis of attention, identifying key brain regions and neural circuits involved in attention processes. The theory further explores neuroplasticity, shedding light on how the brain dynamically adapts and changes to optimize attention. A comprehensive overview of TMS is provided, elucidating the principles and applications of this technique in affecting brain activity through magnetic field stimulation. The application of TMS in attention research is discussed, outlining how it can be employed to regulate attention networks. The clinical applications of TMS are explored in attention-deficit/hyperactivity disorder (ADHD) and depression. TMS emerges as an effective clinical treatment for ADHD, showcasing its potential in addressing attention-related disorders. Additionally, the paper emphasizes the efficacy of TMS technology as a method for regulating depression, further underlining the versatility and therapeutic potential of TMS in clinical settings. In conclusion, this review underscores the interdisciplinary approach to attention research, integrating neuroimaging, neuroplasticity, and TMS. The presented findings contribute to our understanding of attention mechanisms and highlight the promising clinical applications of TMS in addressing attention-related disorders. This synthesis of theoretical and practical insights aims to propel further advancements in attention research and its therapeutic applications.

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“…In a rat model, HF-rTMS applied during the acute and subacute phase of cerebral ischemia inhibited apoptosis by significantly enhancing the expression of Bcl-2 and reducing the expression of Bax compared to controls [ 149 , 150 ]. The use of c-TBS was reported to have an inhibitory effect on the activation of caspase-3 and caspase-9 [ 20 ], while rTMS can increase the ratio of LC3-II/I and decrease p62 through NMDAR–Ca 2+ –mTOR signaling [ 151 ]. Although this TMS effect can be important for poststroke recovery, it is not completely clear if this potentially augmented autophagy of TMS is eliciting a beneficial effect through clearance of the postischemic debris rather than prevention of neuronal death.…”

Section: Transcranial Magnetic Stimulation—short Introductionmentioning

confidence: 99%

From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review

et al. 2023

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Stroke is a major health problem worldwide, with numerous health, social, and economic implications for survivors and their families. One simple answer to this problem would be to ensure the best rehabilitation with full social reintegration. As such, a plethora of rehabilitation programs was developed and used by healthcare professionals. Among them, modern techniques such as transcranial magnetic stimulation and transcranial direct current stimulation are being used and seem to bring improvements to poststroke rehabilitation. This success is attributed to their capacity to enhance cellular neuromodulation. This modulation includes the reduction of the inflammatory response, autophagy suppression, antiapoptotic effects, angiogenesis enhancement, alterations in the blood-brain barrier permeability, attenuation of oxidative stress, influence on neurotransmitter metabolism, neurogenesis, and enhanced structural neuroplasticity. The favorable effects have been demonstrated at the cellular level in animal models and are supported by clinical studies. Thus, these methods proved to reduce infarct volumes and to improve motor performance, deglutition, functional independence, and high-order cerebral functions (i.e., aphasia and heminegligence). However, as with every therapeutic method, these techniques can also have limitations. Their regimen of administration, the phase of the stroke at which they are applied, and the patients’ characteristics (i.e., genotype and corticospinal integrity) seem to influence the outcome. Thus, no response or even worsening effects were obtained under certain circumstances both in animal stroke model studies and in clinical trials. Overall, weighing up risks and benefits, the new transcranial electrical and magnetic stimulation techniques can represent effective tools with which to improve the patients’ recovery after stroke, with minimal to no adverse effects. Here, we discuss their effects and the molecular and cellular events underlying their effects as well as their clinical implications.

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High-Frequency Repetitive Transcranial Magnetic Stimulation Mediates Autophagy Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin Signaling

Abstract: Wang et al. rTMS-Mediated Autophagy Flux Conclusion: In the 0.5 T group, high-frequency rTMS can induce autophagy through NMDAR-Ca 2+-ERK-mTOR signaling in BMSCs. In the 1.0 and 1.5 T groups, autophagy is not activated.

Cited by 7 publications

References 23 publications

Gradient Nanoaggregation in a Magnetically Actuated Scaffold for Multiscale Immunoregulation and Microenvironment Remodeling Accelerates Nerve and Muscle Repair

Gradient Nanoaggregation in a Magnetically Actuated Scaffold for Multiscale Immunoregulation and Microenvironment Remodeling Accelerates Nerve and Muscle Repair

The Use of Transcranial Magnetic Stimulation in Attention Optimization Research: A Review from Basic Theory to Findings in Attention-Deficit/Hyperactivity Disorder and Depression

From Molecule to Patient Rehabilitation: The Impact of Transcranial Direct Current Stimulation and Magnetic Stimulation on Stroke—A Narrative Review

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