Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells

Tinfo, Nicole; Hotchkiss, Michelle G.; Buckalew, Angela R.; Zorrilla, Leah M.; Cooper, Ralph L.; Laws, Susan C.

doi:10.1016/j.reprotox.2010.11.005

Cited by 51 publications

(22 citation statements)

References 25 publications

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“…By themselves, the ovaries will secrete significant amounts of P 4 in response to ATRZ. It had previously been shown that cultures of granulosa cells treated with ATRZ in vitro responded with an increase in P 4 (Tinfo et al 2011). In addition, data from our laboratory (J M Goldman, L K Davis and A S Murr, unpublished observations) have demonstrated that 4 days of ATRZ exposure to immature female rats treated with pregnant mare serum gonadotropin caused Values for individual animals within a treatment group were shifted along the horizontal axis according to the presence of the LH peak.…”

Section: Discussionmentioning

confidence: 82%

“…The increase in E 2 was primarily reported from in vitro studies (Sanderson et al 2000, Pogrmic-Majkic et al 2010, Tinfo et al 2011, although a few publications with rodents have reported either marginal effects on aromatase activity or small statistically significant elevations in circulating E 2 (Rivest et al 2010, VictorCosta et al 2010. In contrast, P 4 and corticosterone have been found to rapidly increase in response to single or multiple oral exposures of ATRZ or its metabolites , Taketa et al 2011.…”

Section: Introductionmentioning

confidence: 99%

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Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

et al. 2013

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Multiple exposures to the herbicide atrazine (ATRZ) were shown to suppress the LH surge in both cycling female rats and those ovariectomized (OVX) and primed with estradiol (E 2 ). A single ATRZ administration was found to induce a prompt and marked increase in progesterone (P 4 ). As exogenous P 4 is known to have a differential effect on the LH surge depending on its temporal relationship with the surge, it was hypothesized that a single treatment in an OVX, E 2 -primed rat would augment the surge, whereas several exposures would cause a decrease. Following four daily treatments with 100 mg/kg, LH surge was suppressed. In contrast, a single ATRZ exposure elevated the surge. Two treatments were without effect. The single administration caused a large increase in P 4 at 30 and 60 min that was likely attributable to adrenal secretion. Four exposures also elevated P 4 after the final treatment, although the duration of the increase was shortened. A single treatment with 0, 10, 30, and 100 mg/kg ATRZ showed similar elevations at the highest concentration in P 4 , the LH peak, and area under the curve (AUC), whereas four exposures reduced the AUC. An increase at 1 h in the expression of Kiss1 in the anteroventral periventricular nucleus suggests that this regional kisspeptin neuronal population has a role in the ATRZ augmentation of the surge. These data support the hypothesis that ATRZ-induced changes in adrenal P 4 can either augment or attenuate the surge depending on the temporal proximity of exposure to the rise in LH.

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Section: Discussionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

et al. 2013

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“…Further, atrazine (300 mg/kg) increased the estrogen-to-androgen ratio in rats (Quignot et al 2012). It (10 μM) also increased progesterone and estradiol production and activity of aromatase (the enzyme that synthesizes estradiol from testosterone) in primary rat granulosa cells (Tinfo et al 2011), and it (0.1 and 10 μM) disrupted steroidogenesis in swine granulosa cells (Basini et al 2012). …”

Section: Pesticidesmentioning

confidence: 99%

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Rattan

Zhou

Chiang

et al. 2017

Journal of Endocrinology

257

150

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Endocrine disrupting chemicals are ubiquitous chemicals that exhibit endocrine disrupting properties in both humans and animals. Female reproduction is an important process, which is regulated by hormones and is susceptible to the effects of exposure to endocrine disrupting chemicals. Disruptions in female reproductive functions by endocrine disrupting chemicals may result in subfertility, infertility, improper hormone production, estrous and menstrual cycle abnormalities, anovulation, and early reproductive senescence. This review summarizes the effects of a variety of synthetic endocrine disrupting chemicals during adult life. The chemicals covered in this review are pesticides (organochlorines, organophosphates, carbamates, pyrethroids, and triazines), heavy metals (arsenic, lead, and mercury), diethylstilbesterol, plasticizer alternatives (di-(2-ethylhexyl) phthalate and bisphenol A alternatives), 2,3,7,8-tetrachlorodibenzo-p-dioxin, nonylphenol, polychlorinated biphenyls, triclosan, and parabens. This review focuses on the hypothalamus, pituitary, ovary, and uterus because together they regulate normal female fertility and the onset of reproductive senescence. The literature shows that several endocrine disrupting chemicals have endocrine disrupting abilities in females during adult life, causing fertility abnormalities in both humans and animals.

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“…Granulosa cells were prepared as described previously with some modifications [26]. Briefly, the female pups were injected subcutaneously with 40 IU PMSG (Sigma, Missouri, USA) to synchronize follicular development.…”

Section: Granulosa Cell Culturementioning

confidence: 99%

Effect of triptolide on estradiol release from cultured rat granulosa cells

Zhang

Liu

et al. 2012

Endocr J

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Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells

Cited by 51 publications

References 25 publications

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

Atrazine-induced elevation or attenuation of the LH surge in the ovariectomized, estrogen-primed female rat: role of adrenal progesterone

Exposure to endocrine disruptors during adulthood: consequences for female fertility

Effect of triptolide on estradiol release from cultured rat granulosa cells

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