Understanding the bioaccumulation of pharmaceutical active compounds by clams Ruditapes decussatus exposed to a UWWTP discharge

Cravo, Alexandra; Silva, Sofia; Rodrigues, João A.; Cardoso, Vítor Vale; Benoliel, Maria João; Correia, Carla; Coelho, Maria Rosário; Rosa, Maria João; Almeida, Cristina

doi:10.1016/j.envres.2021.112632

Cited by 14 publications

(10 citation statements)

References 65 publications

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“…However, there have been parallel studies, with shorter time series, of microbial contamination, metals and pesticides that are also relevant to water quality (Bebianno et al, 2019;Moreira da Silva et al, 2019). Microbiological contamination is still a concern (Cravo et al, 2015(Cravo et al, , 2022aGalvão et al, 2019) is further evidence of metal, pesticide and pharmaceutical contamination and pollution (Silva et al, 2021;Cravo et al, 2022b). 3.…”

Section: Discussionmentioning

confidence: 99%

“…The human pressures are increasing with population increase in the Algarve, from ∼395000 in the 2001 census to 467000 in the 2021 census (Intituto National de Estatistica portal consulted on 30/08/2022 1 ). The main threats now include erosion, storm 10.3389/fevo.2022.508218 surges and overtopping (Carrasco et al, 2021;Domingues et al, 2021); climate change (Brito et al, 2012b;Rodrigues et al, 2021); flooding and sea level rise (Lopes et al, 2022); sewage (Cravo et al, 2022a); eutrophication and hypoxia (Cravo et al, 2020); pharmacological contamination (Cravo et al, 2022b) and chemical pollution (Silva et al, 2021).…”

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confidence: 99%

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Assessing the effectiveness of management measures in the Ria Formosa coastal lagoon, Portugal

et al. 2022

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The Ria Formosa is an important transitional and coastal lagoon on the south coast of Portugal that provides valuable ecosystem services. The lagoon is a protected area under national and international conventions. There is a great potential for Blue Growth sectors, such as aquaculture and coastal tourism, but these rely on good water quality. European environmental legislation, such as the Water Framework Directive, requires member states, such as Portugal to implement management measures if a surface water body is not of good ecological status. This work addresses the effectiveness of management measures, such as wastewater treatment plant implementation and dredging, on the water quality of the Ria Formosa coastal lagoon system. This is an important social-ecological issue, since management measures can be very expensive. The ecological status of Ria Formosa was evaluated, according to the physico-chemical and biological quality elements of the Water Framework Directive. The main indicators were the physico-chemical quality elements of nutrient and oxygen condition, and the biological quality element chlorophyll a, as a proxy for phytoplankton biomass, under the Water Framework Directive. The data for these quality elements from the Ria Formosa were analyzed for consistency with the classification for the Water Framework Directive water bodies. The data after the implementation of management measures was compared with historical data to evaluate if these measures had been effective. The relation between nutrient pressures, meteorological and hydrological conditions was addressed, especially rainfall and runoff. Results showed a decrease in nutrient concentration after the management interventions, despite the increase of population and intensifying agriculture in the catchment. The Ecological Status is spatially variable with an overall moderate status, indicating the need for further management measures. There is a significant reduction in nutrient pressure on the lagoon during drought years. This indicates that climate change may alter the structure and function of the lagoon in the future.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Assessing the effectiveness of management measures in the Ria Formosa coastal lagoon, Portugal

et al. 2022

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“…Due to the wide range of polarities of the target PhACs (0.61 < p K a < 18.52; −0.09 < log K OW < 5.19), two chromatographic methods were applied, one in an acidic medium and another in a basic medium. 36 In the acidic method, mobile phase A was a mixture of H 2 O + 0.01 mM ammonium acetate (NH 4 Ac) + 0.5% formic acid (HCOOH) (V/V) and mobile phase B was 100% methanol (MeOH). The gradient program started with 95% mobile phase A, followed by a linear decrease to 50% until 3.0 min, 30% until 5.5 min, and 10% until 8.0 min (held for 2.0 min).…”

Section: Methodsmentioning

confidence: 99%

Different approaches for estimation of the expanded uncertainty of an analytical method developed for determining pharmaceutical active compounds in wastewater using solid-phase extraction and a liquid chromatography coupled with tandem mass spectrometry method

et al. 2023

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“…It is well known that the wastewater treatment plants (WWTPs) are often unable to remove them completely, allowing their release into the environment [ 9 , 10 ]. In the case of PhACs, due to their constant release into the seas, even those that can undergo degradation may behave as pseudopersistent contaminants [ 11 ]. This continued exposure may present unexpected risks in the organisms that inhabit them such as reproductive disorders, survival of susceptible species, growth rate or development of bacterial resistance and endocrine disruption, among others [ 8 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…The decision 2022/1307/EC [ 16 ], includes some PhACs such as the antibiotics sulfamethoxazole and trimethoprim, or the antidepressant venlafaxine and its main metabolite, O-desmethylvenlafaxine, with a maximum permitted detection limit of 100 ng g −1 for the antibiotics and 6 ng g −1 for the others. Although quantitative analysis of PhACs in aquatic ecosystems is limited, as dilution makes detection difficult, the use of bioindicator species is valuable in assessing system contamination, since they are able to reflect bioavailability in a variability of concentrations in both water and sediment [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

et al. 2022

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There is increasing scientific evidence that some pharmaceuticals are present in the marine ecosystems at concentrations that may cause adverse effects on the organisms that inhabit them. At present, there is still very little scientific literature on the (bio)accumulation of these compounds in different species, let alone on the relationship between the presence of these compounds and the adverse effects they produce. However, attempts have been made to optimize and validate analytical methods for the determination of residues of pharmaceuticals in marine biota by studying the stages of sample treatment, sample clean-up and subsequent analysis. The proposed bibliographic review includes a summary of the most commonly techniques, and its analytical features, proposed to determine pharmaceutical compounds in aquatic organisms at different levels of the trophic chain in the last 10 years.

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Understanding the bioaccumulation of pharmaceutical active compounds by clams Ruditapes decussatus exposed to a UWWTP discharge

Cited by 14 publications

References 65 publications

Assessing the effectiveness of management measures in the Ria Formosa coastal lagoon, Portugal

Assessing the effectiveness of management measures in the Ria Formosa coastal lagoon, Portugal

Different approaches for estimation of the expanded uncertainty of an analytical method developed for determining pharmaceutical active compounds in wastewater using solid-phase extraction and a liquid chromatography coupled with tandem mass spectrometry method

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

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