Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery

Shetty, Aishwarya; Chikhaliwala, Priyal; Suryawanshi, J.A. Saonere; Chandra, Sudeshna

doi:10.1007/s40139-021-00221-5

Cited by 2 publications

(3 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It could be involved in drug interaction in three ways like physical encapsulation, electrostatic interactions and covalent conjugation. [4] The different kinds of moderations from dendrimer-coated nanomaterials have confirmed the excellent enhancement of anti-tumour potency. One of the excellent and well-known polymeric drug bearer systems is polyamidoamine dendrimers.…”

Section: Introductionmentioning

confidence: 93%

“…The dendrimeric molecule has been emerged as a promising drug carrier due to excellent properties as well as membrane interaction. It could be involved in drug interaction in three ways like physical encapsulation, electrostatic interactions and covalent conjugation [4] . The different kinds of moderations from dendrimer‐coated nanomaterials have confirmed the excellent enhancement of anti‐tumour potency.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

et al. 2023

View full text Add to dashboard Cite

One of the most severe health diseases affect the mankind is cancer. The treatment methods such as magnetic hyperthermia, chemotherapy, photothermal therapy and MRI‐traced cancer drug delivery system have been available for cancer treatment. The prime of cancer treatment is Chemotherapy but it has not proved the proper satisfaction due to the resistance developed in the tumour. Now‐a‐days, dendrimers are the most important and powerful drug carriers in the anticancer applications. The polyamidoamine (PAMAM) dendrimers have played wider role and the addition of nanomaterials in polyamidoamine dendrimer provided great results in the anticancer properties and medicinal applications. In recent years, researchers have interested to undergo investigation on dendrimer supported nanomaterials due to the outstanding experimental results against the cancer cells. Therefore, the main goal of the article is to deliberate the comprehensive overview of the properties, anticancer applications of the nanomaterials supported dendrimer as the nanocarrier for the anticancer applications.

show abstract

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

et al. 2023

View full text Add to dashboard Cite

show abstract

“…PAMAM can be functionalized easily by engineering surface functional groups, modifying core and branching, which might help to balance efficiency and toxicity. [ 75 ] While PAMAM has been used for the delivery of siRNA [ 76 ] and pDNA, [ 77 ] it has yet to be successfully used by itself for mRNA delivery. [ 78 ] However, by combining a modified PAMAM dendrimer with PEG‐lipid, a replicon RNA‐based vaccine was developed that provided protective immunity against several pathogens.…”

Section: Current Designsmentioning

confidence: 99%

Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

Yang

Mixich

Boonstra

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Messenger RNA (mRNA)-based therapies offer great promise for the treatment of a variety of diseases. In 2020, two FDA approvals of mRNA-based vaccines have elevated mRNA vaccines to global recognition. However, the therapeutic capabilities of mRNA extend far beyond vaccines against infectious diseases. They hold potential for cancer vaccines, protein replacement therapies, gene editing therapies, and immunotherapies. For realizing such advanced therapies, it is crucial to develop effective carrier systems. Recent advances in materials science have led to the development of promising nonviral mRNA delivery systems. In comparison to other carriers like lipid nanoparticles, polymer-based delivery systems often receive less attention, despite their unique ability to carefully tune their chemical features to promote mRNA protection, their favorable pharmacokinetics, and their potential for targeting delivery. In this review, the central features of polymer-based systems for mRNA delivery highlighting the molecular design criteria, stability, and biodistribution are discussed. Finally, the role of targeting ligands for the future of RNA therapies is analyzed.

show abstract

Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery

Cited by 2 publications

References 99 publications

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

Effective Role of Polyamidoamine (PAMAM) Dendrimer Functionalized Nanomaterials in Anticancer Applications

Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

Contact Info

Product

Resources

About