Understanding partial saturation in paper microfluidics enables alternative device architectures

Buser, Joshua R.; Byrnes, Samantha A.; Anderson, Caitlin; Howell, Arielle J.; Kauffman, Peter; Bishop, Joshua D.; Wheeler, Maxwell H.; Kumar, Sujatha; Yager, Paul

doi:10.1039/c8ay01977k

Cited by 13 publications

(13 citation statements)

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“…Attractive alternatives to both instrumental techniques and dipstick test strips are paper-based devices. , Paper-based devices often rely on precisely patterned hydrophilic channels through which the sample solutions flow, facilitated by capillary action and controlled using hydrophobic barriers. Sequentially timed delivery of reagents, and thus multistep processes, can be mediated by this controlled flow . These channels can be utilized to eliminate sample pretreatments, such as purification, concentration, dilution, or reagent addition, that are often required prior to instrumentation-based techniques.…”

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confidence: 99%

“…These channels can be utilized to eliminate sample pretreatments, such as purification, concentration, dilution, or reagent addition, that are often required prior to instrumentation-based techniques. Additional benefits of paper-based devices include that they require only microliter quantities of sample, as opposed to milliliter volumes required for instrumentation-based quantification, and often can be analyzed by naked-eye detection, smartphones, , or flatbed scanners. − Based on these known advantages of paper-based devices and the continued need for improved sensors for onsite nitrite detection, we aimed to construct a nitrite-sensitive paper-based device that improves upon the limitations of known techniques and enables highly sensitive, robust, and practical onsite detection.…”

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confidence: 99%

“…Sequentially timed delivery of reagents, and thus multistep processes, can be mediated by this controlled flow. 12 These channels can be utilized to eliminate sample pretreatments, such as purification, concentration, dilution, or reagent addition, that are often required prior to instrumentationbased techniques. Additional benefits of paper-based devices include that they require only microliter quantities of sample, as opposed to milliliter volumes required for instrumentationbased quantification, 12 and often can be analyzed by naked-eye detection, smartphones, 13,14 or flatbed scanners.…”

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confidence: 99%

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Ultrasensitive Detection of Nitrite through Implementation ofN-(1-Naphthyl)ethylenediamine-Grafted Cellulose into a Paper-Based Device

2020

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Reported herein is the immobilization of N-(1naphthyl)ethylenediamine (NED) on cellulose via an epichlorohydrin (ECH)-based covalent attachment and the implementation of the functionalized cellulose into an ultrasensitive, paper-based device for nitrite detection. The reported functionalization procedure resulted in a 12.9-fold higher functionalization density than the density that results from the previously reported procedures, and the subsequent device allows for nitrite detection limits in synthetic freshwater and real seawater of 0.26 and 0.22 μM, respectively. The sensor is efficient in a wide range of temperature, humidity, turbidity, and salinity conditions and has been successfully applied for nitrite detection in real water samples.

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Ultrasensitive Detection of Nitrite through Implementation ofN-(1-Naphthyl)ethylenediamine-Grafted Cellulose into a Paper-Based Device

2020

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“…Urine has many advantages as a biomedical sample, including natural abundance, noninvasiveness and biological richness. Consequently, many microfluidic lab-on-paper platforms for urine analysis and disease detection have been proposed in recent years [100,108,164,165]. Many devices have also been successfully commercialized around the world, including the HiPee S2 smart urine analyzer (Tianjin Guo-Shih Tech.…”

Section: Discussionmentioning

confidence: 99%

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

et al. 2021

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In recent years, microfluidic lab-on-paper devices have emerged as a rapid and low-cost alternative to traditional laboratory tests. Additionally, they were widely considered as a promising solution for point-of-care testing (POCT) at home or regions that lack medical infrastructure and resources. This review describes important advances in microfluidic lab-on-paper diagnostics for human health monitoring and disease diagnosis over the past five years. The review commenced by explaining the choice of paper, fabrication methods, and detection techniques to realize microfluidic lab-on-paper devices. Then, the sample pretreatment procedure used to improve the detection performance of lab-on-paper devices was introduced. Furthermore, an in-depth review of lab-on-paper devices for disease measurement based on an analysis of urine samples was presented. The review concludes with the potential challenges that the future development of commercial microfluidic lab-on-paper platforms for human disease detection would face.

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“…Hence, Darcy's law cannot be utilized for accurate modeling in these cases. Buser et al 25,26 proposed a model of flow in partially saturated paper substrates by using the Richards equation, which relates the change in saturation of the porous medium with the pressure head gradient. This can be expressed as…”

Section: ■ Introductionmentioning

confidence: 99%

Microfluidics on Porous Substrates Mediated by Capillarity-Driven Transport

Kar

Das

Laha

et al. 2020

Ind. Eng. Chem. Res.

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Microfluidic systems on porous substrates, including paper-based analytical platforms, have attracted significant attention in recent times, primarily attributed to their diversified applications ranging from bio-analytical devices for healthcare technologies to green energy generation and flexible electronics. In this short review, we attempt to provide a concise overview about the fundamental premises of functionalities of these devices, starting from the understanding of flow in single one-dimensional conduit. This can be extended to more complex systems, where an intrinsic capillary action offers the necessary provisions for continuous maintenance of heterogeneous flow over multiple spatio-temporal scales, which essentially facilitates the needs of specific applications. We discuss about few specific applications as demonstrative examples which are solely triggered by the intrinsic capillary action of the porous media. These specific examples delineate the fact that flexible architecture of the devices in combination with the inherent capillary driven phenomena makes it suitable to meet the desired user-specific demands at affordable costs, rendering them immensely suitable for the low resource settings environment.

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Understanding partial saturation in paper microfluidics enables alternative device architectures

Abstract: A closer look at flow in paper microfluidic devices enables more advanced diagnostic assay automation using the same inexpensive materials.

Cited by 13 publications

References 50 publications

Ultrasensitive Detection of Nitrite through Implementation ofN-(1-Naphthyl)ethylenediamine-Grafted Cellulose into a Paper-Based Device

Ultrasensitive Detection of Nitrite through Implementation ofN-(1-Naphthyl)ethylenediamine-Grafted Cellulose into a Paper-Based Device

Lab-on-Paper Devices for Diagnosis of Human Diseases Using Urine Samples—A Review

Microfluidics on Porous Substrates Mediated by Capillarity-Driven Transport

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