Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960’s

Li, Shuzhao; Cirillo, Piera M.; Hu, Xin; Tran, ViLinh; Krigbaum, Nickilou Y.; Yu, Shaojun; Jones, Dean P.; Cohn, Barbara A.

doi:10.1016/j.reprotox.2019.06.013

Cited by 28 publications

(28 citation statements)

References 46 publications

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“…Thus, reduction of dimensional complexity will be possible by grouping correlated exposures. Indeed, several reports have shown correlation patterns between different chemicals and chemical families within populations (20,21). These relationships between chemicals can be presented as networks of chemicals (i.e.…”

Section: Integrating Chemical Knowledgementioning

confidence: 99%

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The exposome and health: Where chemistry meets biology

Vermeulen

Schymanski

Barabási

et al. 2020

Science

620

426

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Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The “exposome” concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted.

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Section: Integrating Chemical Knowledgementioning

confidence: 99%

“…These relationships between chemicals can be presented as networks of chemicals (i.e. exposure enrichment pathways) that unveil communities of exposures (20,21), which in turn can be used to explore the impact that they have on the biological system (see network science below).…”

Section: Integrating Chemical Knowledgementioning

confidence: 99%

The exposome and health: Where chemistry meets biology

Vermeulen

Schymanski

Barabási

et al. 2020

Science

620

426

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“…The number of studies related to the exposome has markedly increased over the past decade [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. A large number of epidemiological studies have sought to identify the associations between exposure to environmental chemicals and different chronic diseases, such as diabetes, cancer, and obesity [ 23 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Exposomics Approach To Study Health and Diseasementioning

confidence: 99%

Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health

et al. 2020

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Human health and well-being are intricately linked to environmental quality. Environmental exposures can have lifelong consequences. In particular, exposures during the vulnerable fetal or early development period can affect structure, physiology and metabolism, causing potential adverse, often permanent, health effects at any point in life. External exposures, such as the “chemical exposome” (exposures to environmental chemicals), affect the host’s metabolism and immune system, which, in turn, mediate the risk of various diseases. Linking such exposures to adverse outcomes, via intermediate phenotypes such as the metabolome, is one of the central themes of exposome research. Much progress has been made in this line of research, including addressing some key challenges such as analytical coverage of the exposome and metabolome, as well as the integration of heterogeneous, multi-omics data. There is strong evidence that chemical exposures have a marked impact on the metabolome, associating with specific disease risks. Herein, we review recent progress in the field of exposome research as related to human health as well as selected metabolic and autoimmune diseases, with specific emphasis on the impacts of chemical exposures on the host metabolome.

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“…Clearly, the environment–MBD link is a critical first step that can be accomplished now using existing data. Moreover, recent experience with archived specimens supports the feasibility of metabolomics studies of WOS samples available in historic prospective cohorts [22,34,35]. Existing archived biological samples can be used to interrogate the individual responses to environmental exposures that distinguish women with higher MBD associated with environmental exposures.…”

Section: Approachmentioning

confidence: 99%

“…New techniques of high-throughput metabolomics can discover pathways to MBD via environmental toxicants and individual responses to these toxicants, including identification of shared pathways that simplify the measurement of predictors. For example, a number of legacy environmental chemicals share metabolic pathways which might be investigated to find women at greatest risk [35].…”

Section: Barriers and Solutionsmentioning

confidence: 99%

Environmental Influences on Mammographic Breast Density in California: A Strategy to Reduce Breast Cancer Risk

Cohn

Terry

2019

IJERPH

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State legislation in many U.S. states, including California, mandates informing women if they have dense breasts on screening mammography, meaning over half of their breast tissue is comprised of non-adipose tissue. Breast density is important to interpret screening sensitivity and is an established breast cancer risk factor. Environmental chemical exposures may play an important role in this, especially during key windows of susceptibility for breast development: in utero, during puberty, pregnancy, lactation, and the peri-menopause. There is a paucity of research, however, examining whether environmental chemical exposures are associated with mammographic breast density, and even less is known about environmental exposures during windows of susceptibility. Now, with clinical breast density scoring being reported routinely for mammograms, it is possible to find out, especially in California, where there are large study populations that can link environmental exposures during windows of susceptibility to breast density. Density scores are now available throughout the state through electronic medical records. We can link these with environmental chemical exposures via state-wide monitoring. Studying the effects of environmental exposure on breast density may provide valuable monitoring and etiologic data to inform strategies to reduce breast cancer risk.

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Understanding mixed environmental exposures using metabolomics via a hierarchical community network model in a cohort of California women in 1960’s

Cited by 28 publications

References 46 publications

The exposome and health: Where chemistry meets biology

The exposome and health: Where chemistry meets biology

Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health

Environmental Influences on Mammographic Breast Density in California: A Strategy to Reduce Breast Cancer Risk

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