Understanding Interferon Subtype Therapy for Viral Infections: Harnessing the Power of the Innate Immune System.

Berry, Cassandra M.

doi:10.1016/j.cytogfr.2016.08.001

Cited by 16 publications

(19 citation statements)

References 66 publications

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“…Studies in which septic shock was reduced by IFN-α (77) or IFN-β delivery (78) that suggest an anti-inflammatory effect for these cytokines need to be reinterpreted. Perhaps, the injected cytokine dose in these two studies elicits non-physiological effects that increase survival, as there is a striking difference between physiological IFN-β levels and those used for treatment (79). The role of IFN-β appears to lie more in propagating the inflammatory response than in initiating it, as its effect differs from that of TNF-α, a potent pro-inflammatory agent that causes septic shock in mice (75).…”

Section: The Role Of Ifn-β In Immune Disease and In Sepsismentioning

confidence: 99%

The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential

et al. 2017

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Sepsis is a complex biphasic syndrome characterized by both pro- and anti-inflammatory immune states. Whereas early sepsis mortality is caused by an acute, deleterious pro-inflammatory response, the second sepsis phase is governed by acute immunosuppression, which predisposes patients to long-term risk for life-threatening secondary infections. Despite extensive basic research and clinical trials, there is to date no specific therapy for sepsis, and mortality rates are on the rise. Although IFN-β is one of the most-studied cytokines, its diverse effects are not fully understood. Depending on the disease or type of infection, it can have beneficial or detrimental effects. As IFN-β has been used successfully to treat diverse diseases, emphasis has been placed on understanding the role of IFN-β in sepsis. Analyses of mouse models of septic shock attribute a pro-inflammatory role to IFN-β in sepsis development. As anti-inflammatory treatments in humans with antibodies to TNF-α or IL1-β resulted disappointing, cytokine modulation approaches were discouraged and neutralization of IFN-β has not been pursued for sepsis treatment. In the case of patients with delayed sepsis and immunosuppression, there is a debate as to whether the use of specific cytokines would restore the deactivated immune response. Recent reports show an association of low IFN-β levels with the hyporesponsive state of monocytes from sepsis patients and after endotoxin tolerance induction. These data, discussed here, project a role for IFN-β in restoring monocyte function and reversing immunosuppression, and suggest IFN-β-based additive immunomodulatory therapy. The dichotomy in putative therapeutic approaches, involving reduction or an increase in IFN-β levels, mirrors the contrasting nature of the early hyperinflammatory state and the delayed immunosuppression phase.

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Section: The Role Of Ifn-β In Immune Disease and In Sepsismentioning

confidence: 99%

The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential

et al. 2017

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“…The powerful anti-viral and anti-tumor effects of IFNs have been evaluated in several clinical studies assessing their efficacy as therapy for autoimmune diseases [92], viral infection, and cervical cancer. Promising results have been achieved with IFN treatment in association with a vaccination against HPV16, consisting of E6-E7 synthetic peptides [93, 94].…”

Section: Immune Modulation By E5 Oncoproteinmentioning

confidence: 99%

hrHPV E5 oncoprotein: immune evasion and related immunotherapies

Freitas

Oliveira

Júnior

et al. 2017

J Exp Clin Cancer Res

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The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene is responsible for modulation of several immune mechanisms, including antigen presentation and inflammatory pathways. Moreover, E5 was suggested as a promising therapeutic target, since there is still no effective medical therapy for the treatment of HPV-related pre-neoplasia and cancer. Indeed, several studies have shown good prospective for E5 immunotherapy, suggesting that it could be applied for the treatment of pre-cancerous lesions. Thus, insofar as the majority of cervical, oropharyngeal and anal cancers are caused by high-risk HPV (hrHPV), mainly by HPV16, the aim of this review is to discuss the immune pathways interfered by E5 oncoprotein of hrHPV highlighting the various aspects of the potential immunotherapeutic approaches.

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“…There are three distinct types of IFNs, type I, II and III, which are classified based on their structural features, target receptors and biological activities. Although type I and type III IFNs are induced in response to viral infections in the respiratory tract, there is emerging evidence that type III IFN is primarily responsible for protection against viral invaders in the respiratory tract and plays an important role in local antiviral innate immunity …”

Section: Introductionmentioning

confidence: 99%

“…Although type I and type III IFNs are induced in response to viral infections in the respiratory tract, there is emerging evidence that type III IFN is primarily responsible for protection against viral invaders in the respiratory tract and plays an important role in local antiviral innate immunity. 6,[8][9][10][11][12][13][14][15] Several studies have documented abnormal immune responses to viral infections in patients with chronic respiratory diseases including allergic asthma. [16][17][18][19] The impairment of antiviral immune responses related to T helper type 2 (Th2) cytokines has been suggested as a mechanism for higher susceptibility to viral infection in the asthmatic respiratory epithelium.…”

Section: Introductionmentioning

confidence: 99%

Type III interferons are critical host factors that determine susceptibility to Influenza A viral infection in allergic nasal mucosa

Jeon

Lim

et al. 2018

Clin Experimental Allergy

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Understanding Interferon Subtype Therapy for Viral Infections: Harnessing the Power of the Innate Immune System.

Abstract: Type I and III interferons (IFNs) of the innate immune system belong to a polygenic family, however

Cited by 16 publications

References 66 publications

The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential

The Role of IFN-β during the Course of Sepsis Progression and Its Therapeutic Potential

hrHPV E5 oncoprotein: immune evasion and related immunotherapies

Type III interferons are critical host factors that determine susceptibility to Influenza A viral infection in allergic nasal mucosa

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