Understanding Cerebellar Liponeurocytomas: Case Report and Literature Review

Oudrhiri, Mohammed Yassaad; Raouzi, Nabil; Kacemi, Inas El; Fatemi, Nizar El; Gana, R.; Maaqili, Moulay Rachid El; Bellakhdar, F.

doi:10.1155/2014/186826

Cited by 14 publications

(16 citation statements)

References 30 publications

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“…The roles of adjuvant chemotherapy and radiation have not been established. 18 In the current cases, lesions from the patient and her mother had comparable immunohistochemical profiles, including variable expression of synaptophysin, MAP-2, NeuN, neurofilament, GFAP, and vimentin. The patient's tumor appeared more differentiated, with a greater lipidized component and stronger expression of neuronal markers.…”

Section: Discussionmentioning

confidence: 56%

Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report

Wolf

Alghefari²,

Krivosheya

et al. 2016

JNS

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C erebellar liponeurocytomas are typically lowgrade tumors that arise in the cerebellar hemispheres or vermis and contain cells of neuronal, astrocytic, and lipomatous differentiation. 17 The biology and long-term outcomes of these tumors are undefined, and to our knowledge, familial occurrences have not been described. We present here the case of a young woman with a cerebellar liponeurocytoma and multiple immediate family members, including her mother, with similar lesions. This report describes the tumors from the patient and her mother and provides a brief overview of the histopathology and genetic changes associated with this disease. case report Clinical PresentationA 37-year-old woman presented with a 2-year history of worsening morning and daytime headaches in the occipital area that radiated over the cranium. She also described intermittent paresthesia in her hands and feet, which was of variable distribution and duration. The patient was otherwise healthy with a grossly normal neurological examination. She smoked cigarettes but had no other known medical problems. CT and MRI of the head and spine revealed a solitary fat-containing tumor arising from the region of the superior cerebellar hemisphere and vermis. The heterogeneous lesion had numerous ill-defined septations with patchy enhancement and measured 4.4 × 4.1 × 4.3 cm in the anterior-posterior, medial-lateral, and superior-inferior dimensions, respectively. It extended through the incisura and involved the tectal plate and several deep veins, including the left basal vein of Rosenthal. There was complete effacement of the fourth ventricle and compensated dilation of the third and lateral ventricles. There was displacement of the cerebellar tonsils through the foramen magnum, with compression of the cervicomedullary junction ( Fig. 1A and B).abbreviatioNs GFAP = glial fibrillary acidic protein; IDH1 = isocitrate dehydrogenase 1; MAP-2 = microtubule-associated protein 2; MIB-1 = monoclonal antihuman Ki 67. The biological origin of cerebellar liponeurocytomas is unknown, and hereditary forms of this disease have not been described. Here, the authors present clinical and histopathological findings of a young patient with a cerebellar liponeurocytoma who had multiple immediate family members who harbored similar intracranial tumors. A 37-year-old otherwise healthy woman presented with a history of progressive headaches. Lipomatous medulloblastoma had been diagnosed previously in her mother and maternal grandfather, and her maternal uncle had a supratentorial liponeurocytoma. MRI revealed a large, poorly enhancing, lipomatous mass emanating from the superior vermis that produced marked compression of posterior fossa structures. An uncomplicated supracerebellar infratentorial approach was used to resect the lesion. Genetic and histopathological analyses of the lesion revealed neuronal, glial, and lipomatous differentiation and confirmed the diagnosis of cerebellar liponeurocytoma. A comparison of the tumors resected from the patient and, 22 years previo...

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Section: Discussionmentioning

confidence: 56%

Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report

Wolf

Alghefari²,

Krivosheya

et al. 2016

JNS

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“…Oudrhiri et al ., in 2013, in his paper, reviewed 36 previously reported cases of liponeurocytoma and found that the average age of occurrence of this lesion was 49 years (range 32–79 years) with a female preponderance (1.8:1). [8] Recent reports also exist in the form of individual cases, the most common being in the infratentorial location. [910111213] Gembruch et al ., in a systematic review of all the reported cases ( n = 73) until 2018, noted that these tumors had low MIB-1 proliferation index (3.73 ± 4.01%).…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Liponeurocytoma: A Rare Fatty Tumor and its Literature Review

Deora

Prabhuraj

Saini

et al. 2019

Journal of Neurosciences in Rural Practice

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Cerebellar liponeurocytoma is a rare oncological entity, and the knowledge about the treatment and outcome of these rare tumors is still evolving. Very few cases have been described in literature. We report a middle-aged male who presented with raised intracranial pressure features and gait ataxia. His imaging features revealed classical features of liponeurocytoma in cerebellar vermis, with abundant fat component evident in both computed tomography and magnetic resonance imaging. He underwent resection of the lesion and has been asymptomatic for 4 years. This report describes the classical radiological and immunohistochemical features of this rare entity with favorable outcome and reviews the existing literature.

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“…Like the cerebellum liponeurocytoma in the CPA tumors, the average age of the onset of this tumor is between the third to fifth decades of life with equal preva-lence in men and women [9]. In the study of 7 cases of liponeurocytoma, 4 patients were male and 3 were female [3,7,[9][10][11][12]. Our patient was a 27-year-old woman.…”

Section: Discussionmentioning

confidence: 99%

“…It is predominantly located in the posterior cranial fossa and characteristically emerging in adults. Lipidized medulloblastoma, lipomatous medulloblastoma and neurolipocytoma are different names that have been considered for this tumor in the past [3,4]. Histopathological examination of the tumor cells presented lipidized cells are found between small neoplastic cells with focal lipomatous differentiation.…”

Section: Background and Importancementioning

confidence: 99%

Liponeurocytoma of the Cerebellopontine Angle: An Interesting Case Report and Literature Review

et al. 2020

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Background and Importance: Liponeurocytoma is a rare tumor of the CNS. Some of its prominent features include low neuronal proliferation with foci of lipomatous differentiation. So far, 70 reports on cases of brain liponeurocytoma have been published. Most of them were located in the cerebellar hemisphere, but only 7 cases of primary Cerebellopontine Angle (CPA) liponeurocytoma have been reported. Case Presentation: We presented a 27-year-old woman with a 6-month progressive headache and dizziness. More recently, she developed progressive hearing loss and ataxia. Pre-operative MRI of the brain demonstrated a heterogeneous solid extra-axial lesion in the right CPA with hydrocephalus. The operation was performed via the retro sigmoid approach. Histopathological diagnosis was confirmed as liponeurocytoma. No radiotherapy was performed. The patient was followed up for two years. There were no signs of recurrence. Conclusion: Liponeurocytoma is a rare tumor. In most of the cases, it is presented in the cerebellum, and the CPA as the primary location of this tumor is extremely uncommon. Typically, surgery is the treatment of choice for these lesions. If the tumor is subtotal, radiotherapy after operation and resection can also be advantageous.

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Understanding Cerebellar Liponeurocytomas: Case Report and Literature Review

Cited by 14 publications

References 30 publications

Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report

Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report

Cerebellar Liponeurocytoma: A Rare Fatty Tumor and its Literature Review

Liponeurocytoma of the Cerebellopontine Angle: An Interesting Case Report and Literature Review

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