Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes

Inoue, Tatsuro; Maeda, Keisuke; Nagano, Ayano; Shimizu, Akio; Ueshima, Junko; Murotani, Kenta; Sato, Keisuke; Tsubaki, Atsuhiro

doi:10.3390/nu12123743

Cited by 63 publications

(47 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hip fracture is mostly caused by osteoporosis in elderly patients, falling or being hit, and patients have symptoms such as lower limb pain, swelling, and limited mobility, which seriously affect the quality of life [ 11 ]. Patients with severe hip fracture need surgical treatment, which causes large surgical trauma, long postoperative recovery time, need to be in bed for a long time, and reduce activities; it will usually prone to serious complications such as bedsores, lung infections, and VTE and even life-threatening, which brings a heavy burden to patients, families, and society [ 12 , 13 ]. Therefore, it is extremely important to care for elderly patients with hip fracture.…”

Section: Discussionmentioning

confidence: 99%

Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture

Peng

Jing

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To explore the effect of the case management mode combined with enhanced recovery after surgery (ERAS) in elderly patients with hip fracture. Methods. A total of 102 elderly hip fracture patients admitted to our hospital from June 2018 to December 2019 were selected. The patients with hip fracture were divided into the control group (n = 51) and the observation group (n = 51) by the random number table method. The control group adopts the conventional nursing mode, and the observation group adopts the case management mode combined with ERAS. The bed activity time, hospitalization time, total hospitalization expenses, and the satisfaction of patients were observed. The numeric rating scale (NRS) was used to assess the patient’s pain before treatment and at 1, 3, and 5 days after treatment. The Harris score was used to assess the patient’s joint motor function before treatment and at the 8th week after treatment. The perioperative complications of the two groups were compared. Result. After treatment, the observation group was better than the control group in terms of out of bed activity time, hospitalization time, total hospitalization expenses, and the satisfaction of patients ( P < 0.05 ). Before treatment, there was no significant difference in NRS scores between the two groups ( P > 0.05 ). After treatment, the NRS scores of the two groups were lower than before treatment, and on days 1, 3, and 5 after treatment, the NRS scores of the observation group were lower than those of the control group ( P < 0.05 ). Before treatment, there was no difference in the Harris score between the two groups ( P > 0.05 ). At the 8th week after treatment, the Harris scores of the two groups were higher than those before treatment, and the Harris scores of the observation group were higher than those of the control group ( P < 0.05 ). The total incidence of perioperative complications in the observation group (4/51) was lower than that in the control group (13/51) ( P < 0.05 ). Conclusion. The application of the case management mode combined with ERAS nursing in elderly patients with hip fracture can improve the clinical symptoms of patients, improve the therapeutic effect, and reduce the occurrence of complications, which is worthy of clinical application.

show abstract

Section: Discussionmentioning

confidence: 99%

Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture

Peng

Jing

2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…A previous report revealed that patients with prevalent vertebral fractures are at an increased risk of developing further fractures, even after adjusting for confounding factors [ 25 ]. Importantly, vertebral and hip fractures could cause impairment in physical function and immobility, thereby leading to sarcopenia [ 5 , 26 , 27 ]. Therefore, prevalent fractures are a common risk factor for the incidence of further fractures and sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease

Saeki

Saito

Kanai

et al. 2021

JCM

View full text Add to dashboard Cite

We investigated the usefulness of the Fracture Risk Assessment tool (FRAX) for predicting sarcopenia in chronic liver disease (CLD). In this cross-sectional study, we evaluated 321 patients with CLD. The FRAX with and without bone mineral density (BMD) was employed to calculate the 10-year risks of major osteoporotic and hip fractures. The FRAX score for high fracture risk was defined as a 10-year major osteoporotic fracture probability of ≥20% or a 10-year hip fracture probability of ≥3%. The diagnosis of sarcopenia was based on the Japan Society of Hepatology criteria. According to the FRAX, with and without BMD, 134 (41.7%) and 193 (60.1%) patients had a high fracture risk, respectively. The high fracture risk group had a significantly higher frequency of sarcopenia than the non-high fracture risk group. FRAX scores of major osteoporotic and hip fractures were negatively correlated with handgrip strength and muscle mass. Using the FRAX with BMD, the cutoff scores of major osteoporotic and hip fractures for predicting sarcopenia were 8.55% (sensitivity/specificity, 0.847/0.568) and 3.35% (0.729/0.746), respectively. Using the FRAX without BMD, they were 18.5% (0.635/0.725) and 7.65% (0.729/0.758), respectively. The FRAX is a simple and convenient screening tool for predicting sarcopenia in patients with CLD.

show abstract

“…Patients with osteosarcopenia also showed a greater impairment of physical performance and balance than those without osteosarcopenia, resulting in an increased risk of falls and fractures [ 87 ]. Furthermore, vertebral and hip fractures can cause impaired physical function and immobility, thereby leading to sarcopenia [ 88 , 89 ]. These findings suggest that osteosarcopenia and fractures are closely interrelated and exacerbate the negative health outcomes of each other.…”

Section: Osteosarcopenia In Chronic Liver Diseasementioning

confidence: 99%

Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease

Saeki

Tsubota

2021

Life

View full text Add to dashboard Cite

The liver plays a pivotal role in nutrient/energy metabolism and storage, anabolic hormone regulation, ammonia detoxification, and cytokine production. Impaired liver function can cause malnutrition, hyperammonemia, and chronic inflammation, leading to an imbalance between muscle protein synthesis and proteolysis. Patients with chronic liver disease (CLD) have a high prevalence of sarcopenia, characterized by progressive loss of muscle mass and function, affecting health-related quality of life and prognosis. Recent reports have revealed that osteosarcopenia, defined as the concomitant occurrence of sarcopenia and osteoporosis, is also highly prevalent in patients with CLD. Since the differentiation and growth of muscles and bones are closely interrelated through mechanical and biochemical communication, sarcopenia and osteoporosis often progress concurrently and affect each other. Osteosarcopenia further exacerbates unfavorable health outcomes, such as vertebral fracture and frailty. Therefore, a comprehensive assessment of sarcopenia, osteoporosis, and osteosarcopenia, and an understanding of the pathogenic mechanisms involving the liver, bones, and muscles, are important for prevention and treatment. This review summarizes the molecular mechanisms of sarcopenia and osteosarcopenia elucidated to data in hopes of promoting advances in treating these musculoskeletal disorders in patients with CLD.

show abstract

Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes

Cited by 63 publications

References 113 publications

Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture

Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture

Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease

Influencing Factors and Molecular Pathogenesis of Sarcopenia and Osteosarcopenia in Chronic Liver Disease

Contact Info

Product

Resources

About