Undernutrition During Suckling Changes the Sensitivity to Haloperidol and Chlorpromazine in Two Behavioural Measures in Weaning Rats

Rocha, João Batista Teixeira da; Santos, José Eduardo Tanus dos; Rocha, Luis E. C.; Kleinpaul, Elcio R.

doi:10.1111/j.1600-0773.1997.tb00040.x

Cited by 12 publications

(5 citation statements)

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“…This behavioral test was adapted from Rocha et al (1997). Catalepsy was measured using a wire grid (25 9 30 cm 2 ) inclined 45°relative to the bench top.…”

Section: Measurement Of Catalepsymentioning

confidence: 99%

Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter

et al. 2009

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The effects of fish oil supplementation on motor disorders, memory dysfunction, and lipid peroxidation (LP) induced by typical neuroleptics were studied. Wistar rats received a suspension prepared with fish oil containing omega-3 fatty acids, water, and Tween 80 (1%) in the place of drinking water (FO group) or vehicle (C group) for 8 weeks. After 4 weeks of treatment, half of the animals of both groups were treated with haloperidol (H and FO + H groups; experiment 1), fluphenazine (F and FO + F groups; experiment 2), or vehicle (C group), administered once a week (12 mg/kg/im) for 4 weeks, maintaining the treatment with FO. Extrapyramidal motor disorders by haloperidol and fluphenazine were observed by an increase in vacuous chewing movements and catalepsy (P < 0.05). These effects were reduced by FO treatment (P < 0.05). Both neuroleptics displayed impairment in memory retention observed by latency time to find the original location of platform in water-maze task, after 4 days of training performed in the last treatment week. This effect was reduced by FO (P < 0.05) to both haloperidol and fluphenazine treatments. Haloperidol increased the LP in plasma and hippocampus, and these effects were decreased by FO treatment (P < 0.05). Fluphenazine increased the LP in plasma and substantia nigra, which were completely decreased by FO treatment (P < 0.05). The FO decreased the motor disorders, memory dysfunction, and oxidative damage typical neuroleptic-induced. Our results indicate that FO exhibits a neuroprotector role useful on diseases related to oxidative damages, and may be considered in the prevention of motor and memory side effects induced by the antipsychotic treatment.

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“…This behavioral test was adapted from Rocha et al (1997). Catalepsy was measured using a wire grid (25 9 30 cm 2 ) inclined 45°relative to the bench top.…”

Section: Measurement Of Catalepsymentioning

confidence: 99%

Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter

et al. 2009

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“…Perinatal undernutrition may change different anatomical, neurochemical, physiological, pharmacological, developmental and behavioral parameters (1)(2)(3)(4)(5)(6)(7). The methods used to produce undernutrition in rats are accompanied by changes in mother-pup interaction (8)(9)(10)(11)(12) and it has been proposed that changes in maternal behavior tend to minimize the effects of undernutrition on offspring growth and development (13,14).…”

Section: Introductionmentioning

confidence: 99%

Influence of the test situation on pup retrieval behavior of normal and undernourished lactating rats

Rocha

Soares

Mello

2002

Braz J Med Biol Res

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Undernutrition of dams and pups disrupts the retrieval efficiency of mothers. However, if the mothers are assessed in their home cages, they spend more time with their litters. In the present study the effect of test conditions on pup retrieval behavior of mothers receiving a 25% (well-nourished group) and 8% casein diet (undernourished group) was examined. In agreement with previous studies, undernourished mothers spent more time with their litters than well-nourished dams as lactation proceeded. Pup retrieval behavior varied with test conditions. In the first experiment, the maternal behavior of dams was assessed by the standard procedure (pups were separated from their mother and scattered over the floor of the home cage). The mother was then returned and the number of retrieved pups was recorded. From day 3 to 8, the retrieval efficiency of undernourished dams decreased, while the retrieval efficiency of well-nourished mothers did not vary. In the second experiment, mothers were subjected to a single retrieval test (on day 9 of lactation) using the procedure described for experiment 1. No difference between well-nourished and undernourished mothers was observed. In the third experiment, seven-day-old pups were separated from the mothers and returned individually to a clean home cage. Dietary treatment did not affect the retrieval efficiency. However, undernourished dams reconstructed the nest more slowly than did well-nourished dams. Taken together, these results suggest that pup retrieval behavior of the undernourished mother is not impaired by dietary restriction when the maternal environment is disturbed minimally. Correspondence

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“…Mice were gently removed from their home cage by their tail and their forepaws were placed over a glass horizontal bar, 0.5 cm in diameter and 30 cm long, which was fixed at a height of 4 cm above the working surface. As proposed by several authors (Barnes et al 1990;Dijk et al 1991;Rocha et al 1997), to perform one catalepsy determination at one time point, the animal was given three trials. The sum (or the average) of these trials make possible to decrease the stress-induced data variability produced by the handling procedure as compared to a single trial per determination.…”

Section: Test Agentsmentioning

confidence: 99%

Conditioning to Injection Procedures and Repeated Testing Increase SCH 23390-Induced Catalepsy in Mice

Chinen

Frussa‐Filho

1999

Neuropsychopharmacology

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The cataleptic behavior induced by the dopamine D 1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D 1 -like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most of these studies may be the involvement of the "repeated measures effect," a behavioral phenomenon well demonstrated for neurolepticinduced catalepsy but not yet investigated for dopamineThe ability of chronic neuroleptic treatment to produce increasing or decreasing degrees of both Parkinsonism in humans (see Hansen and Hoffman 1997) and catalepsy in laboratory animals (Barnes et al. 1990) over time remains controversial. Specifically, concerning the evolution of catalepsy during chronic haloperidol treatment, tolerance (Asper et al. 1973;Ezrin-Waters and Seeman 1977;Campbell and Baldessarini 1981), sensitization (Antelman et al. 1986;Kinon and Kane 1989;Barnes et al. 1990), or no effects (György et al. 1969;Moller Nielsen et al. 1974;Frussa-Filho et al. 1992) have been reported. Although the patterns of change in catalepsy responses to chronic neuroleptic treatment are influenced by multiple determinants (Barnes et al. 1990), two specific biological mechanisms seem to be of particular importance in determining the development of tolerance or sensitization: dopamine receptor supersensitivity (Ezrin-Waters and Seeman 1977;Hoffman and Beninger 1988) and a learning process due to repeated testing in the catalepsy apparatus (Iwata et al. 1989;Ferré et al. 1990), respectively. In regards to the learning process, both repeated measures in a single session after acute haloperidol administration (Stanley and Glick 1976;Hillegaart et al. 1987 Received October 12, 1998; revised April 30, 1999; accepted May 17, 1999. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 21 , NO . 5 Conditioning and SCH 23390-Induced Catalepsy 671 et al. 1990) have been reported to markedly enhance the cataleptic behavior presented by rodents.For many years, dopamine D 2 -like receptors were implicated as the only site mediating the cataleptic behavior of neuroleptics (Seeman 1980). However, in 1984, Christensen et al. (1984 first reported the cataleptogenic properties of SCH 23390, a selective antagonist of D 1 -like dopamine receptors (Hyttel 1983). Thus, besides providing a functional correlate of dopamine D 1 receptor antagonism (Mizuki et al. 1996), SCH 23390-induced catalepsy has proven to be a useful assay for investigating the functional interactions between D 1 -and D 2 -like dopamine receptors (see Klemm 1993). Catalepsy has also been used to investigate the sensitivity of D 1 -like dopamine receptor-mediated effects during chronic drug administration. In two landmark investigations, Hess et al. (1986Hess et al. ( , 1988 reported that although chronic treatment of rats with SCH 23390 resulted in an increase in D 1 -like striatal dopamine receptors as well as in spontaneous locomotion and D 1 -like and D 2 -like dopamine agonist-induced stereotypy, no tolerance to the cataleptic effect ...

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Undernutrition During Suckling Changes the Sensitivity to Haloperidol and Chlorpromazine in Two Behavioural Measures in Weaning Rats

Cited by 12 publications

References 53 publications

Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter

Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter

Influence of the test situation on pup retrieval behavior of normal and undernourished lactating rats

Conditioning to Injection Procedures and Repeated Testing Increase SCH 23390-Induced Catalepsy in Mice

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