Underlying liver disease influences volumetric changes in the spared hemiliver after selective internal radiation therapy with ⁹⁰Y in patients with hepatocellular carcinoma

Abstract

Administration of unilobar SIRT to the right liver lobe in patients with HCC resulted in a significant degree of contralateral left lobe hypertrophy. Patients with hepatitis B experienced a greater degree of hypertrophy than those with hepatitis C or alcoholic liver cirrhosis.

Contra-lateral liver lobe hypertrophy after unilobar Y90 radioembolization: An alternative to portal vein embolization?

“…Subsequently, several groups have also published similar results from their retrospective experience [15][16][17][18][19][20][21][22] . The main limitations of these retrospective studies are that the patient cohorts were vastly heterogenous in terms of pathology treated, underlying liver disease, dosage and delivery of Y90, number of treatment sessions and time to measurement of hypertrophy.…”

A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90

“…20 Nine studies, published between 2008 and 2014 were identified. [11][12][13][14][15][16][17][18][19] Three studies 11,12,15 were reported from the same centre with overlapping patient cohorts. Two studies 11,12 were excluded; and only the most recent (and largest) report 15 was included.…”

Limits of and Complications after Embolization of the Hepatic Artery and Portal Vein to Induce Segmental Hypertrophy of the Liver: A Large Mini-Pig Study

“…Promising results have recently been published after selective internal radiation therapy (SIRT), using a less invasive arterial access in patients with primary liver malignancies, showing low morbidity rates and comparable hypertrophy rates of the future liver remnant in comparison to PVE [35,36,37,38]. This new therapy leads to an internal radiation of the liver tumor via microspheres with a decrease in the tumor size.…”