A systematic review of contralateral liver lobe hypertrophy after unilobar selective internal radiation therapy with Y90

Abstract

Background: Curative liver resection is the treatment of choice for both primary and secondary liver malignancies. However, an inadequate future liver remnant (FLR) frequently precludes successful sur-

Multidisciplinary management of liver metastases in patients with colorectal cancer: a consensus of SEOM, AEC, SEOR, SERVEI, and SEMNIM

“…Currently, Y 90 microspheres may also be a reasonable alternative in patients who are potential candidates for resection but display a small FLR [14]. Although PVE is the gold-standard modality for inducing hypertrophy of the FLR [59], Garlipp et al [60] showed a lesser, but still pronounced, benefit of Y 90 particles with regard to contralateral liver hypertrophy after TARE. Moreover, TARE minimizes the risk of tumor progression in the treated lobe, possibly making it a suitable modality for selected patients.…”

Significance of neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio and prognostic nutrition index as preoperative predictors of early mortality after liver resection for huge (≥10 cm) hepatocellular carcinoma

“…Preoperative identification of patients who had these poor predictor factors and hence were at high risk of early mortality after surgical resection would enable clinicians to better select and counsel patients for resection based on their individual risk‐benefit ratio for surgical resection. Presently, with the development of newer, less invasive treatments for HCC, such as Y‐90 SIRT, which has been shown to more effective than conventional TACE for large tumors , some of these patients could potentially benefit from a less aggressive treatment approach.…”

Histopathological changes resulting from selective internal radiotherapy (SIRT)

“…Analyzing the effects of SIRT on liver volume, several groups described an increase in volume of the contralateral lobe together with atrophy of the targeted lobe. [28][29][30] Analyzing the histopathological changes in the liver, we found liver atrophy after SIRT together with slight signs of hypertrophy in the non-targeted lobe. Despite the small number of patients in this sub-group, our findings support the clinical effects of SIRT on liver volume.…”