Underlying causes of cerebral palsy: public health perspectives

Kapanova, Gulnara; Malik, Shynar; Adylova, Aima

doi:10.5114/fn.2021.112019

Cited by 3 publications

(2 citation statements)

References 37 publications

(47 reference statements)

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“…About 19,000 of these children are diagnosed with cerebral palsy. Cerebral palsy is a pressing problem in Kazakhstan (Kapanova, Malik, & Adylova, 2021;Nurgaliyeva et al, 2020;Zhakupova et al, 2023). There are many reasons leading to disability in children.…”

Section: Problem Statementmentioning

confidence: 99%

Task-oriented training effect on promoting motor skills and daily physical activities in learners with musculoskeletal impairment

Baygaliev,

Butabayeva,

Autayeva

et al. 2024

JEELR

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Children frequently suffer from motor impairments which hinder their development. Every movement requires stability therefore; musculoskeletal malfunction leads to poor movement. Task-oriented training is one of many methods and techniques used to promote motor skills and daily physical activities in children. The present study's goal is to investigate how task-oriented training contributes to developing motor skills and daily physical activities in learners with cerebral palsy. The study employed a mixed- data collection strategy. The study included a total of 12 students with cerebral palsy. The promotion of a child's motor abilities and regular physical activity can be accomplished with the help of task-oriented training. The study's findings supported our hypothesis that task-oriented training that has been devised and a series of exercises to increase range of motion (flexibility) led to positive dynamics in all groups of indicators regardless of the severity of the pathology. The proposed program allowed children to increase muscle strength and range of motion in the joints. Thus, after the experimental work, the functional state of the musculoskeletal system improved and qualitative and significant changes occurred in the independence of learners. It is suggested that teachers use task-oriented training when instructing school-age children who have this disorder.

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Section: Problem Statementmentioning

confidence: 99%

Task-oriented training effect on promoting motor skills and daily physical activities in learners with musculoskeletal impairment

Baygaliev,

Butabayeva,

Autayeva

et al. 2024

JEELR

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“…CP etiology typically includes neonatal HIBD, maternal infections during pregnancy, intrauterine trauma, and preterm birth (Galea et al, 2019;Sanches et al, 2021). Notably, hypoxia-ischemia plays a crucial role in CP diagnosis (Kapanova et al, 2021). The Rice-Vannucci model is widely used in animal studies, particularly in rodent models of CP, wherein cerebral HI is induced to simulate CP (Cavarsan et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Early-stage effect of HIBD on neuro-motor function and organic composition of neurovascular units in neonatal rats

Mo,

Zeng,

Huo

et al. 2023

Front. Neurosci.

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ObjectiveThis study aimed to investigate the effects of neonatal hypoxic–ischemic brain damage (HIBD) on early-stage neuro-motor function, cerebral blood flow, and the neurovascular unit.MethodsTwenty-four Sprague–Dawley newborn rats aged 7 days were obtained and randomly assigned to either the sham or the model group using a random number table. The HIBD model was established using the Rice-Vannucci method. After the induction of HIBD, the body weight of the rats was measured and their neuro-motor function was assessed. Further, cerebral blood flow perfusion was evaluated using laser speckle flow imaging, and immunofluorescent staining techniques were employed for examining the activation of specific markers and their morphological changes in different cell populations, which included vascular endothelial cells, neurons, astrocytes, and microglia within the motor cortex.ResultsAfter HIBD, the model group exhibited impaired neuro-motor function and growth. Cerebral blood flow perfusion decreased in both the hemispheres on day 1 and in the ipsilateral brain on day 4. However, no significant difference was observed between the two groups on day 7. Moreover, the CD31 and NeuN showed a sharp decline on day 1, which was followed by a gradual increase in the expression levels. The activated microglia and astrocytes formed clusters in the injured cortex. Notably, the regions with positive staining for Arg-1, Iba-1, CD68, and GFAP consistently displayed higher values in the model group as compared to that in the sham group. The total number of branch endpoints and microglia branches was higher in the model group than in the sham group. Immunofluorescent co-localization analysis revealed no co-staining between Iba-1 and Arg-1; however, the Pearson’s R-value for the co-localization of Iba-1 and CD68 was higher in the model group, which indicated an increasing trend of co-staining in the model group.ConclusionEarly-stage neuro-motor function, cerebral blood flow, microvasculature, and neurons in neonatal rats exhibited a trend of gradual recovery over time. The activation and upregulation of neuroglial cells continued persistently after HIBD. Furthermore, the impact of HIBD on early-stage neuro-motor function in newborn rats did not synchronize with the activation of neuroglial cells. The recovery of neuro-motor function, microvasculature, and neurons occurred earlier than that of neuroglial cells.

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Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors

Zhakupova¹,

Нурбакыт²,

Ospanova³

et al. 2023

Heliyon

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Underlying causes of cerebral palsy: public health perspectives

Cited by 3 publications

References 37 publications

Task-oriented training effect on promoting motor skills and daily physical activities in learners with musculoskeletal impairment

Task-oriented training effect on promoting motor skills and daily physical activities in learners with musculoskeletal impairment

Early-stage effect of HIBD on neuro-motor function and organic composition of neurovascular units in neonatal rats

Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors

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