Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats

Agbonifo-Chijiokwu, Ejime; Nwangwa, Kingsley E.; Oyovwi, Mega O.; Ben‐Azu, Benneth; Naiho, A. O.; Emojevwe, Victor; Ohwin, Ejiro Peggy; Ehiwarior, Azuka Prosper; Ojugbeli, Evelyn Tarela; Nwabuoku, Shalom Udoka; Moke, Emuesiri Goodies; Oghenetega, Bright Onome

doi:10.1007/s40200-022-01173-2

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…Secara keseluruhan, hasil penelitian ini menunjukkan bahwa Moderate Intensity Exercise selama 12 minggu dapat menghasilkan penurunan glukosa darah pada pasien dengan diabetes tipe 2. Meskipun penurunan glukosa darah tersebut tidak signifikan secara statistik pada pagi hari, namun terdapat penurunan yang signifikan pada BEBG, PEBG, dan EIGR pada bulan pelatihan kedua dan ketiga dibandingkan dengan bulan pertama dengan nilai (P<.001) (Agbonifo-Chijiokwu et al, 2023).…”

Section: Pembahasanunclassified

Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2

Budiman,

Pramukti,

Nursiswati

2023

JOTING

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This study aims to map and synthesize evidence regarding the effectiveness of low to high-intensity exercise in reducing blood sugar levels in type 2 DM patients according to patient characteristics. The method used is a scoping review with a search strategy using the PICO(s) format. Pubmed, Science Direct, CINAHL, and the Google Scholar search engine are the databases used. The research results showed that eight articles were in English, five studies showed a significant reduction in blood sugar, and three others showed no significant decrease. Apart from that, it was also found that there was an increase in insulin, which showed a significant increase in HbA1c, and there was no increase in the dose of anti-diabetic therapy. Several types of exercise are used at all intensities depending on the patient's ability, including walking, jogging, power cycling, and walking on a treadmill. In conclusion, exercise can reduce weight for obese patients and increase muscle strength, followed by improved physical function for patients with weight loss. Keywords: Diabetes Mellitus Type 2, Exercise Therapy, Blood Glucose

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Section: Pembahasanunclassified

Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2

Budiman,

Pramukti,

Nursiswati

2023

JOTING

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“…After a meal, there is an increase in the blood glucose level which stimulates insulin secretion. On the other hand, when in fasting conditions, the brain uses up the stored up glucose and this is independent on insulin (Röder et al, 2016. Agbonifo-Chijiokwu et al, 2023.…”

Section: Pathophysiology Of Diabetes Mellitusmentioning

confidence: 99%

Coexistence of hypertension with diabetes mellitus and its pharmacotherapy

Moke,

Demaki,

Daubry

et al. 2023

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Diabetes mellitus and hypertension are common comorbidities, as hypertension is reported to be twice as frequent in diabetic patients as people who are non- diabetics. In diabetic condition, the risk and progression of cardiac disease, peripheral vascular disease, stroke, retinopathy, and nephropathy is greatly increased in the presence of hypertension. Persistent increase in blood pressure termed hypertension, can be either primary hypertension (essential hypertension) or secondary hypertension in nature. Primary or essential hypertension is characterized by elevated blood pressure caused by inherited factors which are characteristic of essential hypertension whereas identifiable causes such as chronic kidney diseases, endocrine disorders, constriction of the kidney arteries, or the use of drugs are among the etiology of secondary hypertension. Diabetes causes hyperinsulinemia which increases the risk of hypertension. This condition increases the amount of sodium that the body absorbs. It also promotes the stimulation of the sympathetic nervous system. Treatment of both conditions is crucial as they are considered risk factors for coronary artery disease, cerebrovascular disease, renal failure and congestive heart failure. In any age group, a considerable increase in systolic blood pressure causes a significant increase in cardiovascular disease. To achieve sufficient blood pressure control, most people with hypertension and diabetes require more than one medication. This review is aimed to discuss hypertension and diabetes mellitus comorbidities and their treatment.

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“…In both comorbid cases, DM and hypertension can be managed by dietary modifications, exercise, and lifestyle changes [27]. With the use of hypoglycaemic drugs such as sulphonylureas, biguanides, thiazolidinediones, alpha-glucosidase inhibitors, and/or insulin, DM can be effectively mitigated [28,29].…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

et al. 2023

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Background Hypertension is a medical condition that often comorbidly exist in patients with type II diabetes. Therefore, it is very important to manage both conditions simultaneously to mitigate the complications and mortality connected with this comorbidity. Hence, this study investigated the antihypertensive and antihyperglycemic effects of combinations of losartan (LOS) with metformin (MET) and/or glibenclamide (GLB) in hypertensive diabetic rats. Hypertensive diabetic state was induced with desoxycorticosterone acetate (DOCA) and streptozotocin (STZ) in adult Wistar rats. The rats were divided into 5 groups (n = 5): control group (group 1), hypertensive diabetic (HD) control (group 2), treatment groups receiving LOS + MET (group 3), LOS + GLB (group 4), and LOS + MET + GLB (group 5). Group 1 comprised healthy rats while groups 2–5 were HD rats. The rats were treated orally once daily for 8 weeks. Fasted blood glucose (FBS) level, haemodynamic parameters, and some biochemical indices were thereafter assessed. Results FBS level and blood pressure measurements were significantly (P < 0.05) increased following induction by DOCA/STZ. The drug treatment combinations, particularly combination of LOS + MET + GLB, significantly (P < 0.05) reduced the induced hyperglycemia and remarkably decreased systolic blood pressure and heart rate. There was significant (P < 0.05) reduction in raised lactate dehydrogenase and creatinine kinase levels by all drug treatment combinations except LOS + GLB. Conclusions Our findings suggest that LOS combinations with MET and/or GLB exhibited significant antidiabetic and antihypertensive effects against DOCA/STZ-induced hypertensive diabetic state in rats.

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Underlying biochemical effects of intermittent fasting, exercise and honey on streptozotocin-induced liver damage in rats

Cited by 7 publications

References 39 publications

Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2

Low to High Intensity Exercise dalam Menurunkan Kadar Gula Darah pada Pasien DM Tipe 2

Coexistence of hypertension with diabetes mellitus and its pharmacotherapy

Antihypertensive and antihyperglycemic effects of combinations of losartan with metformin and/or glibenclamide in desoxycorticosterone acetate and streptozotocin-induced hypertensive diabetic rats

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