Under the microscope: From pathogens to probiotics and back

Sleator, Roy D.

doi:10.1080/21655979.2015.1089368

Cited by 6 publications

(2 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On comparison, the alpha diversity index between FMT-treated group and control concluded that the FMT therapy elevated the bacterial diversity of the intestinal microbiota and enriched with therapy duration compare with control. In addition, as demonstrated in beta diversity, the distribution of intestinal bacterial community during FMT was dispersed obviously, closely cluster observed in FMT-treated 8 weeks and 12 weeks (A2 and A3), while the control microbial distribution was concentrated among FMT-treated 1, 8, and 12 weeks ( Figure 4 ), that indicated the altered bacterial community contributed by FMT therapy and similar result also identified in previous studies [ 39 , 40 ]. Moreover, the correlation among dominant genus demonstrated that Prevotella was positively with Megamonas (0.62), negatively with Bacteroides (−0.83) and Blautia (−0.65).…”

Section: Resultssupporting

confidence: 85%

Dynamic changes of intestinal flora in patients with irritable bowel syndrome combined with anxiety and depression after oral administration of enterobacteria capsules

et al. 2021

View full text Add to dashboard Cite

This study investigated the clinical characteristics and dynamic changes of intestinal bacterial community to evaluate the curative effect of fecal microbiota transplantation (FMT) on irritable bowel syndrome with predominant diarrhea (IBS-D) comorbid with anxiety and depression. Total two treatments were designed in randomize-controlled trial includes oral FMT capsules with 1 week (A1), 8 weeks (A2), and 12 weeks (A3), as well as oral empty capsules with 1 week (B1), 8 weeks (B2), and 12 weeks (B3) as control for comparison. The positive therapeutic effects occurred in FMT colonized patient with IBS-D comorbid psychological disorder, demonstrated at alleviated IBS-D severity (IBS-SSS score from 291.11 reduced to 144.44), altered stool type (from 6 changed to 4), reduced anxiety and depression scores (from 18.33 to 8.39 and from 22.33 to 17.78) after FMT-treated 12 weeks. The FMT therapy improved bacterial alpha diversity and the majority bacterial community predominant by Bacteroidetes and Firmicutes , and the relative abundance (RA) was higher after FMT-treated 12 weeks (50.61% and 45.52%) than control (47.62% and 38.96%). In short, FMT therapy has great potential for IBS-D patients combined with anxiety and depression by alleviated clinical symptoms and restore the intestinal micro-ecology.

show abstract