Uncovering the Dorsal Thalamo-hypothalamic Tract of the Human Limbic System

Kamali, Arash; Karbasian, Niloofar; Sherbaf, Farzaneh Ghazi; Wilken, Lindsay A.; Aein, Azin; Sair, Haris I.; Arevalo, Octavio; Rabiei, Pejman; Choi, Sally J.; Mirbagheri, Saeedeh; Riascos, Roy F.; Hasan, Khader M.

doi:10.1016/j.neuroscience.2020.02.021

Cited by 13 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our cohort, these patients who exhibited hippocampal T2 hyperintensities were either seizure-free or had rare seizures, thereby making seizure-related MRI changes an unlikely explanation for these changes. [13][14][15] Subsequent to studying this population, we have seen a few more cases with hippocampal involvement attributable to vigabatrin effect without any alternative explanation. We have also noticed mesial temporal lobe involvement on a displayed image in 1 prior published study reporting on vigabatrin-related MRI changes, where there was posterior hippocampal diffusion restriction, not mentioned in the study text.…”

Section: Discussionmentioning

confidence: 93%

See 1 more Smart Citation

Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding

et al. 2021

View full text Add to dashboard Cite

Background: In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities. Methods: A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features. Results In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes. Conclusions: Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Furthermore, because we did not observe a direct correlation between drug-induced electrophysiological changes and clinical changes, we believe that the latter were not a result of a reduction in the frequency of headache pain. Finally, because a significant decrease in hypothalamic activation, a so-called migraine generator, was observed only in patients responding to erenumab (6), we cannot rule out an indirect modulatory effect of the hypothalamus on functionally connected brain structures, such as the caudal trigeminal nucleus (26) and the parietal cortex (27).…”

Section: Discussionmentioning

confidence: 99%

The monoclonal CGRP-receptor blocking antibody erenumab has different effects on brainstem and cortical sensory-evoked responses

et al. 2022

View full text Add to dashboard Cite

Objectives It is unclear whether the electrophysiological effects of erenumab, a monoclonal antibody against the calcitonin gene-related peptide receptor, occur only at the periphery of the trigeminal system or centrally and at the cortical level. Methods We prospectively enrolled 20 patients with migraine who had failed at least two preventative treatments. We measured the nociceptive blink reflex and non-noxious somatosensory evoked potentials in all participants. The area under the curve and habituation of the second polysynaptic nociceptive blink reflex component (R2) as well as the amplitude and habituation of somatosensory evoked potentials N20-P25 were measured. Electrophysiological data were collected at baseline (T0), 28 days (T1), and 56 days (T2) before each injection of erenumab (70 mg). Results Erenumab reduced the patients’ mean monthly headache days, headache intensity, and acute medication intake considerably at T1 and T2 (all p < 0.05). The nociceptive blink reflex area under the curve was considerably lower at T1 and T2 than at baseline without changing the habituation slope. At T2, there was a significant increase in the delayed somatosensory evoked potentials amplitude reduction (habituation) but not in the initial cortical activation. Conclusion Our findings showed that erenumab, in addition to its well-known peripheral effects, can induce central effects earlier in the brainstem and later in the cortex. We cannot rule out whether these results are due to a direct effect of erenumab on the central nervous system or an indirect effect secondary to peripheral drug modulation.

show abstract

“…Recently, Kamali's team was the first to reconstruct the dorsal thalamo-hypothalamic tract, revealing in the meantime the existence of a direct connection from the dorsal thalamus to the ventral hypothalamic nuclei ( 74 ). The authors hypothesized that since the thalamus constitutes a hub for somatosensory information, the dorsal thalamic nuclei could carry sensory information from the thalamus to the limbic system, in particular to the HT.…”

Section: Structural Connectivity Of Hypothalamusmentioning

confidence: 99%

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

et al. 2022

View full text Add to dashboard Cite

Hypothalamus (HT), this small structure often perceived through the prism of neuroimaging as morphologically and functionally homogeneous, plays a key role in the primitive act of feeding. The current paper aims at reviewing the contribution of magnetic resonance imaging (MRI) in the study of the role of the HT in food intake regulation. It focuses on the different MRI techniques that have been used to describe structurally and functionally the Human HT. The latest advances in HT parcellation as well as perspectives in this field are presented. The value of MRI in the study of eating disorders such as anorexia nervosa (AN) and obesity are also highlighted.

show abstract

Uncovering the Dorsal Thalamo-hypothalamic Tract of the Human Limbic System

Cited by 13 publications

References 38 publications

Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding

Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding

The monoclonal CGRP-receptor blocking antibody erenumab has different effects on brainstem and cortical sensory-evoked responses

The Role of the Human Hypothalamus in Food Intake Networks: An MRI Perspective

Contact Info

Product

Resources

About