Uncovering spatial representations from spatiotemporal patterns of rodent hippocampal field potentials

Abstract

SUMMARY Spatiotemporal patterns of large-scale spiking and field potentials of the rodent hippocampus encode spatial representations during maze runs, immobility, and sleep. Here, we show that multisite hippocampal field potential amplitude at ultra-high-frequency band (FPA uhf ), a generalized form of multiunit activity, provides not only a fast and reliable reconstruction of the rodent’s position when awake, but also a readout of replay content during sharp-wave ripples. This FPA uhf feature may serve as a robust real-time decoding strategy from large-scale recordings in closed-loop experiments. Furthermore, we develop unsupervised learning approaches to extract low-dimensional spatiotemporal FPA uhf features during run and ripple periods and to infer latent dynamical structures from lower-rank FPA uhf features. We also develop an optical flow-based method to identify propagating spatiotemporal LFP patterns from multisite array recordings, which can be used as a decoding application. Finally, we develop a prospective decoding strategy to predict an animal’s future decision in goal-directed navigation.

Excitatory-Inhibitory Recurrent Dynamics Produce Robust Visual Grids and Stable Attractors

“…Based on first-order Taylor series expansion, the following equation can be derived or where . We then used the Horn-Schunck estimation method to estimate the optical flow based on neighboring frames (Horn and Schunck 1981; Cao et al 2021). The optical flow was represented and visualized by a 2D vector field, with arrows indicating the direction, and the size of arrow proportional to the scale.…”

Working memory features are embedded in hippocampal place fields

“…Therefore, details about animals, virus injections, surgical procedures, behavioral tests and recording can be found in the respective publications. 27 , 52 , 53 Besides the aforementioned publications, extensive description of all experiments used in this study can be found in the Buzsaki lab database ( https://buzsakilab.com/wp/projects/entry/67125/ , 28 ; ). Hence, all procedures not relevant for this study will only be briefly mentioned here.…”

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