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Learning and memory are assumed to be supported by mechanisms that involve cholinergic transmission and hippocampal theta. Using G protein–coupled receptor-activation–based acetylcholine sensor (GRABACh3.0) with a fiber-photometric fluorescence readout in mice, we found that cholinergic signaling in the hippocampus increased in parallel with theta/gamma power during walking and REM sleep, while ACh3.0 signal reached a minimum during hippocampal sharp-wave ripples (SPW-R). Unexpectedly, memory performance was impaired in a hippocampus-dependent spontaneous alternation task by selective optogenetic stimulation of medial septal cholinergic neurons when the stimulation was applied in the delay area but not in the central (choice) arm of the maze. Parallel with the decreased performance, optogenetic stimulation decreased the incidence of SPW-Rs. These findings suggest that septo–hippocampal interactions play a task-phase–dependent dual role in the maintenance of memory performance, including not only theta mechanisms but also SPW-Rs.

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Adiabatic wavelength conversion is experimentally demonstrated at a single photon power-level using an integrated silicon ring resonator. This approach allows conversion of a photon to arbitrary wavelengths with no energy or phase matching constraints. The conversion is inherently low-noise and efficient with greater than 10% conversion efficiencies for wavelength changes up to 0.5 nm, more than twenty times the resonators line-width. The observed wavelength change and efficiency agrees well with theory and bright coherent light demonstrations. These results will enable integrated quantum optical wavelength conversion for application ranging from wavelength-multiplexed quantum networks to frequency bin entanglement.