Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening

Oosten, Anne S. G. van; Vahabi, M.; Licup, Albert James; Sharma, Abhinav; Galie, Peter A.; MacKintosh, F. C.; Janmey, Paul A.

doi:10.1038/srep19270

Cited by 135 publications

(162 citation statements)

References 40 publications

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“…1a, black). This softening response is consistent with previous studies of fibrin 22,23,35 and actin 36 and may indicate fiber buckling 35,[37][38][39] . Even for pure spring networks, however, extension tends to stabilize networks while compression tends to destabilize networks 40,41 .…”

Section: Resultssupporting

confidence: 92%

“…We show that fibrin networks undergo strong and irreversible stiffening when subject to axial compression. We apply a compressive strain, since this mode of deformation is most adept for strain-induced programming due to the volume-reducing nature of the deformation 22,23 . This is in contrast with most studies on intra-and extracellular matrices, which focused on shear deformation.…”

Section: Introductionmentioning

confidence: 99%

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Programming the mechanics of cohesive fiber networks by compression

et al. 2017

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Fibrous networks are ideal functional materials since they provide mechanical rigidity at low weight. Here, we demonstrate that fibrous networks of the blood clotting protein fibrin undergo a strong and irreversible increase in their mechanical rigidity in response to uniaxial compression. This rigidification can be precisely controlled by the level of applied compressive strain, providing a means to program the network rigidity without having to change its composition. To identify the underlying mechanism we measure single fiber-fiber interactions using optical tweezers. We further develop a minimal computational model of cohesive fiber networks that shows that stiffening arises due to the formation of new bonds in the compressed state, which develop tensile stress when the network is re-expanded. The model predicts that the network stiffness after a compression cycle obeys a power-law dependence on tensile stress, which we confirm experimentally. This finding provides new insights into how biological tissues can adapt themselves independently of any cellular processes, offering new perspectives to inspire the design of reprogrammable materials.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Programming the mechanics of cohesive fiber networks by compression

et al. 2017

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“…Such rheological sensitivity to particle density mirrors that of biological materials such as blood clots, which consist of a fibrous fibrin network with entrapped cells and platelets. Materials of this type soften under compression in the manner of a classical polymer network 424 but exhibit stiffening behaviour if water is lost, increasing the density of the fibre network. 425 Stiffness perturbations are thought to play an important role in cellular development, signalling and disease processes, as changes to the characteristic rheological properties of tissues can strongly influence the shapes, motilities, growth rates and differentiation pathways of constituent cells.…”

Section: Gels Under Stressmentioning

confidence: 99%

Gels with sense: supramolecular materials that respond to heat, light and sound

2016

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. (2016) 'Gels with sense : supramolecular materials that respond to heat, light and sound.', Chemical society reviews., 45 (23). pp. 6546-6596. Further information on publisher's website:https://doi.org/10.1039/C6CS00435KPublisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Advances in the field of supramolecular chemistry have made it possible, in many situations, to reliably engineer soft materials to address a specific technological problem. Particularly exciting are "smart" gels that undergo reversible physical changes on exposure to remote, non-invasive environmental stimuli. This review explores the development of gels which are transformed by heat, light and ultrasound, as well as other mechanical inputs, applied voltages and magnetic fields. Focusing on small-molecule gelators, but with reference to organic polymers and metal-organic systems, we examine how the structures of gelator assemblies influence the physical and chemical mechanisms leading to thermo-, photo-and mechano-switchable behaviour. In addition, we evaluate how the unique and versatile properties of smart materials may be exploited in a wide range of applications, including catalysis, crystal growth, ion sensing, drug delivery, data storage and biomaterial replacement.

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“…Fibrin mechanics was studied and modeled under simultaneous uniaxial compression or extension combined with shear deformations that better mimic multidirectional strains occurring in vivo [100]. A complex interplay between shear and Young's moduli in response to these complex deformations was modeled based on undulations, bending, and buckling of individual fibers.…”

Section: Modeling Fibrin Mechanical Propertiesmentioning

confidence: 99%

Fibrin mechanical properties and their structural origins

2017

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Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing, and several other biological functions and pathological conditions that involve extracellular matrix. In addition to molecular and cellular interactions, fibrin mechanics has been recently shown to underlie clot behavior in the highly dynamic intra- and extravascular environment. Fibrin has both elastic and viscous properties. Perhaps the most remarkable rheological feature of the fibrin network is an extremely high elasticity and stability despite very low protein content. Another important mechanical property that is common to many filamentous protein polymers but not other polymers is stiffening occurring in response to shear, tension, or compression. New data has begun to provide a structural basis for the unique mechanical behavior of fibrin that originates from its complex multi-scale hierarchical structure. The mechanical behavior of the whole fibrin gel is governed largely by the properties of single fibers and their ensembles, including changes in fiber orientation, stretching, bending, and buckling. The properties of individual fibrin fibers are determined by the number and packing arrangements of double-stranded half-staggered protofibrils, which still remain poorly understood. It has also been proposed that forced unfolding of sub-molecular structures, including elongation of flexible and relatively unstructured portions of fibrin molecules, can contribute to fibrin deformations. In spite of a great increase in our knowledge of the structural mechanics of fibrin, much about the mechanisms of fibrin's biological functions remains unknown. Fibrin deformability is not only an essential part of the biomechanics of hemostasis and thrombosis, but also a rapidly developing field of bioengineering that uses fibrin as a versatile biomaterial with exceptional and tunable biochemical and mechanical properties.

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Uncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening

Cited by 135 publications

References 40 publications

Programming the mechanics of cohesive fiber networks by compression

Programming the mechanics of cohesive fiber networks by compression

Gels with sense: supramolecular materials that respond to heat, light and sound

Fibrin mechanical properties and their structural origins

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