Uncoupling gene–diet interactions in inflammatory bowel disease (IBD)

Ferguson, Lynnette R.; Peterman, Ivonne; Hübner, Claudia; Philpott, Martin; Shellin, Andrew N.

doi:10.1007/s12263-007-0012-y

Cited by 10 publications

(6 citation statements)

References 8 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the most common complications of IBD is anemia, caused by iron, zinc, folate, and vitamin B 12 deficiency (140). Zinc is critically involved in DNA replication and transcription and has immunoregulatory effects (141). Iron, folate, and vitamin B 12 are critical for hemoglobin/blood cell formation.…”

Section: Role Of Diet In Controlling Bacterial Contributions To Ibdmentioning

confidence: 99%

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

et al. 2019

View full text Add to dashboard Cite

SUMMARYGut bacteria play a key role in initiating and maintaining the inflammatory process in the gut tissues of inflammatory bowel disease (IBD) patients, by supplying antigens or other stimulatory factors that trigger immune cell activation. Changes in the composition of the intestinal microbiota in IBD patients compared to that in healthy controls and a reduced diversity of intestinal microbial species are linked to the pathogenesis of IBD. Adherent invasiveEscherichia coli(AIEC) has been linked to Crohn’s disease (CD) patients, while diffusely adherentE. coli(DAEC) has been associated with ulcerative colitis (UC). Bacteriological analysis of intestinal biopsy specimens and fecal samples from IBD patients shows an increased number ofE. colistrains belonging to the B2 phylogenetic group, which are typically known as extraintestinal pathogenicE. coli(ExPEC). Results from studies of both cell cultures and animal models reveal pathogenic features of theseE. colipathobionts, which may link them to IBD pathogenesis. This suggests that IBD-associatedE. colistrains play a facilitative role during IBD flares. In this review, we explain IBD-associatedE. coliand its role in IBD pathogenesis.

show abstract

Section: Role Of Diet In Controlling Bacterial Contributions To Ibdmentioning

confidence: 99%

Escherichia coli Pathobionts Associated with Inflammatory Bowel Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The pathology of CD is characterized by the T helper (Th) 1 response, which is mediated by high levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and tissue-infiltrating Th17 cells. In contrast, the pathology of UC is characterized by the atypical Th2 response, mediated by high levels of Th17 cells [ 5 , 6 ].…”

Section: Defining Inflammatory Bowel Diseasementioning

confidence: 99%

Microbiome, Metabolome and Inflammatory Bowel Disease

et al. 2016

View full text Add to dashboard Cite

Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn’s Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing. Nonetheless, studies are ongoing to examine the effect of pre/probiotics and/or FODMAP reduced diets on both the gut microbiome and its metabolome in an effort to define the healthy diet in patients with IBD. Knowledge of a unique metabolomic fingerprint in IBD could be useful for diagnosis, treatment and detection of disease pathogenesis.

show abstract

“…IBDs cause nutritional deficiencies, such as calorie and protein malnutrition, and deficiencies in vitamins, minerals and trace elements. This underscores the importance of nutritional therapy in their treatment (Ferguson et al 2007, Pizato et al 2005, Razack et al 2007. Malnutrition is common in these patients, and interventions through adequate nutritional therapy so as to restore the nutritional status have been associated with an improved recovery process involving the improvement of the immune system during periods of the exacerbation of the disease (Razack et al 2007).…”

Section: Inflammatory Bowel Disease and Carcinogenesismentioning

confidence: 99%