Uncommon Presentations of Non-Hodgkin’s Lymphoma

Quintini, Gerlando; Barbera, Vincenzo; Franco, Vito; Florena, Ada Maria; Spadola, Vincenzo; Mariani, Giuglielmo

doi:10.1200/jco.2003.12.132

Cited by 14 publications

(6 citation statements)

References 3 publications

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“…Most cases of primary renal NHL reportedly progress rapidly and display a poor prognosis [6]. In the present case, we performed intensive chemotherapy as treatment for stage III DLBCL in the solitary remaining kidney after nephrectomy of the right kidney.…”

Section: Discussionmentioning

confidence: 90%

Primary pediatric stage III renal diffuse large B-cell lymphoma

et al. 2013

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SummaryBackground:Although secondary renal involvement of non-Hodgkin lymphoma is frequently encountered, primary renal lymphoma is quite rare. We present a pediatric case of primary renal diffuse large B-cell lymphoma.Case Report:A 12-year-old girl presenting with gross hematuria was referred to our hospital. Abdominal ultrasonography and imaging revealed a mass lesion in the superior pole of the right kidney. Serum creatinine and blood urea nitrogen levels were within normal ranges. Preoperative assessment of the mass indicated unspecified renal tumor. Right nephrectomy was performed and pathological examination showed diffuse large B-cell lymphoma. Postoperative fluorodeoxyglucose-positron emission tomography/computed tomography showed a small high-uptake lesion in the thyroid gland and aspiration cytology of the thyroid tumor demonstrated involvement of lymphoma, so stage III tumor diagnosed. After one course of chemotherapy, the patient achieved complete remission. She remains alive without disease, 3 years after completing a total of six courses of chemotherapy.Conclusions:Primary renal lymphoma is a very rare entity and preoperative diagnosis may be difficult. However, this entity is often reported to show clinically aggressive characteristics and therefore should be considered among the differential diagnoses for unusual renal tumors in pediatric patients.

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Section: Discussionmentioning

confidence: 90%

Primary pediatric stage III renal diffuse large B-cell lymphoma

et al. 2013

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“…Neoplastic cells are rarely seen in bone marrow and peripheral blood smears and so IVLBCL is very difficult to diagnose; most of the cases reported have been confirmed by autopsy or cutaneous biopsies [ 6 ]. IVLBCL diagnosed in prostate specimens is extremely rare in the literature, usually reported as single cases; to the best of our knowledge, this is the 10th such case reported [ 1 , 7 , 8 , 9 , 10 , 11 , 12 ]. Furthermore, none of the patients in the study by Murase et al, with a large series of 96 patients, were diagnosed with prostatic involvement, indicating the rarity of infiltration in this site [ 6 ].…”

Section: Discussion and Review Of The Literaturementioning

confidence: 95%

“…Despite the defined geographical differences, neurological symptoms at initial diagnosis were reported in high incidences in both the Asian and Western types of the disease at 25% and 36%, respectively [ 1 , 17 ]. Among the few cases reported with prostatic involvement, 2 patients presented with neurological signs indicating spinal cord lesions [ 8 , 9 ]. Our patient had some neurological symptoms interpreted as myelitis according to MR findings, and following p-TUR surgery with spinal anesthesia, paraparesis developed.…”

Section: Discussion and Review Of The Literaturementioning

confidence: 99%

Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

Özsan¹,

Sarsık²,

Şimşir³

et al. 2014

Tjh

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Intravascular large B-cell lymphoma (IVLBCL) is a very rare type of non-Hodgkin lymphoma, usually affecting elderly patients and characterized by selective infiltration of neoplastic cells within blood vessels’ lumina. IVLBCL diagnosed with prostatic involvement is extremely rare. We report a patient of 65 years old, having mostly neurological complaints but diagnosed with IVLBCL upon histopathological examination of transurethral prostate resection material, which revealed large neoplastic cell infiltration totally limited within the lumens of small vessels. By immunohistochemistry, neoplastic cell infiltration was positive with MUM1, bcl-6, and bcl-2 and negative with ALK1, CD10, and CD30, with a high Ki-67 proliferation index. CD34 and CD31 staining showed expression in endothelial cells, highlighting the intravascular nature of neoplastic infiltrate. The patient unfortunately refused to receive treatment and died of the disease 8 months after the diagnosis. IVLBCL, though very rare, should be considered in differential diagnosis of all organ biopsies with intravascular infiltration. Further improvements in the understanding of the pathogenesis and biology of this rare type of lymphoma are mandatory.

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“…Median survival is less than a year. [5] PRL is considered as a systemic disease, presenting with renal manifestation. However, nephrectomy can be avoided if a preoperative diagnosis is made.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity of renal biopsy are 70% to 92% and 100%, respectively, with accuracy close to 90%. [5] The treatment of renal lymphoma depends on the primary histological subtype. The addition of Rituximab to the standard CHOP chemotherapy may improve the dismal outcome reported so far.…”

Section: Discussionmentioning

confidence: 99%

Primary renal lymphoma mimicking renal cell carcinoma

et al. 2010

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Primary renal lymphoma is very rare. Lymphomatous involvement of the kidney is often seen as a part of disseminated disease. The prognosis is usually poor with median survival less than a year. It is essential to differentiate between renal cell carcinoma and renal lymphoma in patients presenting with solitary renal masses. We present a 52-year-old lady who presented with a solitary renal mass and was diagnosed to have primary lymphoma of the kidney and discuss briefly about primary renal lymphoma.

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Uncommon Presentations of Non-Hodgkin’s Lymphoma

Cited by 14 publications

References 3 publications

Primary pediatric stage III renal diffuse large B-cell lymphoma

Primary pediatric stage III renal diffuse large B-cell lymphoma

Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

Primary renal lymphoma mimicking renal cell carcinoma

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