Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

Özsan, Nazan; Sarsık, Banu; Şimşir, Adnan; Dönmez, Ayhan

doi:10.4274/tjh.2013.0090

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Moreover, CT showed ground-glass opacities of lung, hepatomegaly, and enlargement of adrenals. Some previous studies showed high frequency of neurological abnormalities on brain magnetic resonance imaging (MRI), and these abnormal findings appeared to relate to ischemic changes of small brain capillaries due to neoplastic lymphoma cells (27)(28)(29)(30)(31)(32)(33)(34)(35). However all patients in four new cases did not present neurological symptoms, and thus, brain MRI was not performed.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature

Han

Wang

et al. 2022

Front. Oncol.

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Intravascular large B-cell lymphoma (IVLBCL) is a rare and highly malignant non-Hodgkin B-cell lymphoma with uncommon clinical presentation and poor prognosis. The diagnostic pitfall of IVLBCL is mainly due to the fact that subtle histological changes could be easily overlooked, in addition to its rare occurrence, non-specific and variable clinical presentations, and the absence of significant mass lesions. The purpose of this study is to further explore the clinicopathologic and molecular features of IVLBCL to ensure an accurate diagnosis of this entity. Here, we retrospectively present the data of the four new cases and the literature cases. The age ranged from 23 to 92, with a medium age of 67 and a male-to-female ratio of 1:1. The clinical manifestations are extremely variable, including fever, night sweats, weight loss, anemia, thrombocytopenia, unexplained hypoxemia, impaired consciousness, and skin lesions, as well as the extremely low levels of serum albumin, high levels of serum lactate dehydrogenase (LDH), soluble interleukin-2 receptor (sIL2R), and ferritin. Morphologically, 99.9% of cases showed a selective growth pattern with large, atypical lymphocytes within the lumen of small blood vessels. In addition, vast majority of cases were positive for CD20, CD79a, PAX5, MUM1, and BCL6, and a subset of cases expressed BCL2 and CD5, whereas CD3 and CD10 were typically negative. Ki-67 proliferative index ranged from 20% to 100%. To sum up, we have conducted comprehensive case reports, to the best of our knowledge, this is the largest reported cohort of IVLBCL cases. Comprehensive assessments and more IVLBCL cases are required for early diagnosis and prompt treatment.

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Section: Discussionmentioning

confidence: 99%

Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature

Han

Wang

et al. 2022

Front. Oncol.

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“…The elevated LDH levels, fever of unknown origin, and unexplained neurological symptoms in elderly patients should raise the suspicious of lymphoma. 4,[6][7][8] It should be differentiated from adenocarcinoma of prostate and secondary metastasis as the treatment protocol varies. Biopsy and immunohistochemical assessment are the gold standard for the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary intravascular large B cell lymphoma of prostate-A diagnostic dilemma

Agarwal

Gandhi²,

Manmohan³

2022

ACHR

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“…[8] The prostate has been reported as one of the involved sites by IVLBCL in few cases. [9][10][11] However, primary prostate IVLBCL was reported only in three cases according to a comprehensive literature search from the electronic databases PubMed with the keywords of "intravascular large B cell lymphoma" and "prostate". [12][13][14] It is lack of the accurate diagnosis and treatment strategy of primary prostate IVLBCL until now.…”

Section: Introductionmentioning

confidence: 99%

A case report of primary prostate intravascular large B cell lymphoma presenting as prostatic hyperplasia

Zhu¹,

Xiao²,

Li³

et al. 2019

Medicine

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Rational: Intravascular large B-cell lymphoma (IVLBCL) is a rare condition with a poor prognosis. The clinical presentation of primary lymphoma of the prostate is non-specific and it is difficult to distinguish from other prostatic diseases. The primary prostate IVLBCL is very rare, the diagnosis and treatment of which remains unclear. We reported a rare case to explore the diagnosis and treatment for the primary prostate IVLBCL.Patients concerns: This report described a case of a 71-year-old male diagnosed as primary prostate IVLBCL who presented with prostatic hyperplasia.Diagnosis: The patient first visited an outpatient clinic of urinary surgery because of urinary urgency and frequency and was diagnosed as benign prostatic hyperplasia in about January 2010. Four years later, the symptoms worsened quickly within two months. The diagnosis was still prostatic hyperplasia according to the physical examination and imaging. However, histopathology showed IVLBCL of prostate after transurethral resection of the prostate.Interventions: With the clear diagnosis of primary prostate stage I IVLBCL, the patient received immunochemotherapy of R-CHOP (rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone) for 4 cycles and intensity-modulated radiation therapy (IMRT) including the region of prostate with the dose of 45Gy/25f.Outcomes: The response was complete remission after all treatment. The last follow-up time of the patient was June 20th, 2019, and no evidence of disease progression was observed. The progression-free survival of the patient was about 49 months until now.Lessons: The biopsy of prostate by prostatectomy plays an important role in the diagnosis and removal of the original lesion of primary prostate lymphoma. There is no consensus on therapeutic modalities for the treatment of primary prostate IVLBCL till now. Individual treatments include immunochemotherapy and/or radiotherapy according to the National Comprehensive Cancer Network (NCCN) practice guideline of diffuse large B cell lymphoma (DLBCL) based on the performance status and tumor staging of the patient. Timely and accurate diagnosis as well as the appropriate treatment may improve the clinical outcome.

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Intravascular Large B-Cell Lymphoma Diagnosed on Prostate Biopsy: A Case Report

Cited by 6 publications

References 20 publications

Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature

Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature

Primary intravascular large B cell lymphoma of prostate-A diagnostic dilemma

A case report of primary prostate intravascular large B cell lymphoma presenting as prostatic hyperplasia

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