Uncommon mycosis in a patient with diabetes

Prasad, Kuruswamy Thurai; Sehgal, Inderpaul Singh; Shivaprakash, M. R.; Dhooria, Sahajal

doi:10.1136/bcr-2016-214453

Cited by 4 publications

(4 citation statements)

References 32 publications

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“…It is believed that diabetic neuropathy which causes dwindling or absence of pain is one factor of the late doctor's consultation. It remains to be found the reasons of the increased frequency of bone and other systemic infections in patients with DM 30 .A rare complication that was recorded on a DM patient was Cryptococcosis 31 . This is a common fungal infection on patients that are under chronic immunosuppressant therapy.…”

Section: Complications Of Diabetes Mellitusmentioning

confidence: 98%

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Okur¹,

Karantas²,

Sıafaka³

2017

actapharm

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Section: Complications Of Diabetes Mellitusmentioning

confidence: 98%

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Okur¹,

Karantas²,

Sıafaka³

2017

actapharm

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“…C. gattii , on the other hand, has long been thought to be a pathogen of immunocompetent persons [ 15 ]. Among the non-HIV patients with cryptococcal pneumonia, severe diabetes mellitus with organ damage is a major risk factor [ 16 , 17 ]. The clinical presentation of pulmonary cryptococcosis is variable and depends on the immune status of the patient.…”

Section: Discussionmentioning

confidence: 99%

Exploring a Rare Pulmonary Coinfection: Cryptococcal Pneumonia and Exophiala dermatitidis in an Immunocompetent Host

Kohli,

Rifai,

Foray

2024

Cureus

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Pulmonary cryptococcosis is becoming increasingly common in immunocompetent hosts, manifesting with variable clinical presentations ranging from asymptomatic colonization to severe pneumonia. Radiological findings are non-specific, such as nodular infiltrates, mass-like lesions, and mediastinal lymphadenopathy. We present a case of a 61-year-old woman with Cryptococcus neoformans pneumonia coinfected with Exophiala dermatitidis, an unusual occurrence in an immunocompetent host and the first of its kind. This coinfection posed significant diagnostic challenges due to the rare occurrence of each individual organism in immunocompetent patients as well as the difficulty of their laboratory diagnosis. Treatment regimens, particularly in coinfections, warrant careful consideration to mitigate mortality risk. This case underscores the importance of comprehensive diagnostic strategies and optimized treatment regimens for rare fungal coinfections in immunocompetent hosts.

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“…Within the 15 immunocompetent patients [ [6] , [7] , [8] , [9] , [10] , [11] , 13 , 17 , 19 , 20 , [22] , [23] , [24] , [25] ], 2 patients [ 22 , 24 ] admitted the exposure to pigeons and 1 patient [ 14 ] suffered from DM. It's worth mentioned that there is another interesting case [ 26 ] of pulmonary cryptococcosis in a diabetic, presenting as lung abscesses and hydropneumothorax without endobronchial lesions, for which it wasn't included in the 21 cases. Whether there is a connection between cryptococcosis and DM is not yet known, which should be further explored.…”

Section: Discussionmentioning

confidence: 99%

A unique case report of endobronchial cryptococcosis and review of the literature

Shuai

Xiong

et al. 2018

Respiratory Medicine Case Reports

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Cryptococcosis is an infection caused by the yeast-like fungus Cryptococcus neoformans. Pulmonary cryptococcosis is typically identified as a single mass or as multiple nodules, while endobronchial lesions are quite rare. Here we report an uncommon case of pulmonary cryptococcosis presenting as endobronchial lesion in an immunocompetent patient. A 49-year-old male patient complained of intermittent cough with hemoptysis for two years. Computerized tomography of the chest showed a filling defect in the basal segment of the right lower lobe bronchus. A flexible bronchoscopic examination revealed a white smooth-surfaced polypoid lesion completely occluding the medial basal segment of the right lower lobe bronchus. The diagnosis was confirmed by bronchial biopsy under bronchoscopy, and the histopathologic findings showed the organisms were Cryptococcal neoformans. The patient was treated with fluconazole at a dose of 400 mg daily. The endobronchial lesion was found rapidly diminished after 18 days of therapy, and disappeared after 6.5 months of therapy by repeated fiberoptic bronchoscopy. Then the patient continued fluconazole for another 2.5 months. During the total 16 months' follow-up visits, the patient repeated CT scanning for five times, the results of which were all normal. The patient's symptoms disappeared as well, and now he is still under follow-up. This case highlights the fact that pulmonary cryptococcosis can present as endobronchial lesions even in immunocompetent subjects, mimicking lung tumor. Pathological confirmation is important to establish the definite diagnosis.

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Uncommon mycosis in a patient with diabetes

Cited by 4 publications

References 32 publications

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives

Exploring a Rare Pulmonary Coinfection: Cryptococcal Pneumonia and Exophiala dermatitidis in an Immunocompetent Host

A unique case report of endobronchial cryptococcosis and review of the literature

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