Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

Luo, Dan; Tu, Zhenchao; Yin, Wenjing; Fan, Chun‐Lin; Chen, Neng‐Hua; Wu, Zhong‐Nan; Ding, Weilong; Wang, Guo‐Cai; Zhang, Yubo

doi:10.3389/fchem.2021.740421

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…It is well known that inflammatory cytokines are important indicators of the immune response in animals; they mediate T, B and other cell activation, proliferation and differentiation and play important roles in the inflammatory response. SA alkaloids inhibited the LPS-induced secretion of proinflammatory cytokines, such as IL-6 and TNF-α, in rats in a dose-dependent manner [38,39], suggesting that SA alkaloids have an inhibitory effect on the inflammatory responses caused by LPS stimulation. Liang et al [40] also reported that, compared with those in the LPS model group, the pathological injury to lung and kidney tissues was reduced to different degrees and that the serum NO, TNF-α, and BUN levels were decreased.…”

Section: Discussionmentioning

confidence: 95%

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

An,

Wang,

Gao

et al. 2024

Animals

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The purpose of this study was to determine the effects of Sophora alopecuroides (SA) on liver function, liver inflammatory factor levels, antioxidant indexes and transcriptome in sheep. Twenty-four 3-month-old healthy Dumont hybrid lambs weighing 25.73 ± 2.17 kg were randomly divided into three groups: C1 (the control group), fed a concentrate-to-forage ratio of 50:50; H2 (the high-concentration group), fed a concentrate-to-forage ratio of 70:30; and S3 (the SA group), fed a concentrate-to-forage ratio of 70:30 + 0.1% SA. The results showed that the rumen pH values of the C1 and S3 groups were significant or significantly higher than that of the H2 group (p < 0.05 or p < 0.01). The serum ALT, AST and LDH activities and the LPS and LBP concentrations in the sheep serum and liver in the H2 group were significantly or extremely significantly higher than those in the C1 and S3 groups (p < 0.01), and the IL-10 content and SOD, GPX-PX and T-AOC activities showed the opposite trend (p < 0.05 or p < 0.01). KEGG enrichment analysis showed that the differentially expressed genes were significantly enriched in the ECM–receptor interaction and focal adhesion pathways, which are closely related to immune and antioxidant functions (p-adjust < 0.1). In summary, SA could improve the immune and antioxidant functions of lamb livers under high-concentrate conditions and regulate the mechanism of damage on sheep livers, which is caused by high-concentrate diets and through the expression of related genes in the ECM/FAs pathway.

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Section: Discussionmentioning

confidence: 95%

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

An,

Wang,

Gao

et al. 2024

Animals

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“…The inhibitory effects of compounds 41-44 on TNF-α and IL-6 in LPS-stimulated RAW264.7 cells were evaluated [50]. The results showed (Table 1) that compounds 43 and 44 have obvious anti-inflammatory effects in a dose-dependent manner.…”

Section: -44mentioning

confidence: 99%

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

Li,

Wei,

Marabada

et al. 2023

Molecules

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Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant Sophora flavescens using an organic solvent. Matrine exhibits a variety of biological activities and is widely used in pharmacy, agronomy, and other fields. Due to its low bioavailability, poor chemical stability, and toxicity to the central nervous system, a large number of researchers have searched for matrine derivatives with higher biological activity and safety by modifying its structure. In this review article, the research progress of matrine derivatives obtained using two methods (extraction from Sophora flavescens and structural modifications) from 2018 to 2022 in terms of pharmacological activity, mechanism of action, and structure–activity relationship are presented. The modification of matrine over the past five years has been mainly on the D-ring. Many new matrine alkaloids have been extracted from natural products, some of which have good pharmacological activity, which broadens the strategy for matrine structural modification in the future.

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Matrine induces cardiotoxicity by promoting ferroptosis through the Nrf2 antioxidant system in H9c2 cells

Wang,

Lin,

Tang

et al. 2024

Toxicology Letters

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Uncommon Bis-Amide Matrine-type Alkaloids From Sophora alopecuroides With Anti-inflammatory Effects

Cited by 4 publications

References 21 publications

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

Matrine induces cardiotoxicity by promoting ferroptosis through the Nrf2 antioxidant system in H9c2 cells

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