Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

Abstract

Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant Sophora flavescens using an organic solvent. Matrine exhibits a variety of biological activities and is widely used in pharmacy, agronomy, and other fields. Due to its low bioavailability, poor chemical stability, and toxicity to the central nervous system, a large number of researchers have searched for matrine derivatives with higher biological activity and safety by modifying its structure. In this review article, the research progress of matrine derivatives obtained using two methods (extraction from Sophora flavescens and structural modifications) from 2018 to 2022 in terms of pharmacological activity, mechanism of action, and structure–activity relationship are presented. The modification of matrine over the past five years has been mainly on the D-ring. Many new matrine alkaloids have been extracted from natural products, some of which have good pharmacological activity, which broadens the strategy for matrine structural modification in the future.

Treatment of neuropathic pain by traditional Chinese medicine: An updated review on their effect and putative mechanisms of action

“…Matrine has been found as the main bioactive ingredient contributing to a variety of pharmacological actions, with fewer side effects, among the numerous alkaloids isolated from Sophora flavescens Ait (Li, Wei, et al, 2023;Sun et al, 2022), exerted neuroprotective effects in vincristine-induced PNP probably by virtue of its anti-oxidative, antiinflammatory, and calcium antagonistic actions (Chhabra & Mehan, 2023).…”

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers

“…Matrine (MAT) is a tetracyclic quinoline alkaloid extracted and isolated from the roots and fruits of Sophora flavescens ( Figure 1 ) [ 1 ]. It has a variety of pharmacological effects, such as antiinflammation effects, oxidative stress reduction, autophagy and apoptosis regulation, and cancer cell metastasis inhibition [ 2 , 3 , 4 , 5 ].…”

Metabolic Profiling for Unveiling Mechanisms of Kushenol F against Imiquimod-Induced Psoriasis with UHPLC/MS Analysis

“…Kushenol F (KSCF) is a natural isopentenyl flavonoid extracted from the root of S. flavescens . It has been reported to have anti-inflammatory and anti-bacterial properties [ 14 , 15 , 16 ]. A previous study demonstrated that KSCF oral treatment could be an important therapeutic for treating atopic dermatitis.…”