Unclear fever 7 weeks after renal transplantation in a 56-year-old patient

Guetgemann, A; Brandenburg, Vincent; Ketteler, Markus; Riehl, J; Floege, Jürgen

doi:10.1093/ndt/gfl280

Cited by 12 publications

(12 citation statements)

References 15 publications

(15 reference statements)

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“…Presentation of Aspergillus thyroiditis was asymptomatic and Aspergillus was shown at autopsy in 2 cases (3–4). However, in 2 other cases (5, 6), involvement of thyroid gland was demonstrated while the patients were alive. One of these cases was a 49‐year‐old cadaveric renal transplant recipient who developed fever 4 months after transplantation (6).…”

Section: Discussionmentioning

confidence: 93%

“…The patient underwent hemithyroidectomy along with attenuation of immunosuppressive regimen.This patient showed a favorable response to amphotericin B and caspofungin combination treatment. The other patient was a 56 -yearold male who underwent cadaveric renal transplantation (5). Seven weeks after transplantation, he presented with fever.…”

Section: Discussionmentioning

confidence: 99%

“…The second case was also on steroid and azathioprine treatment and had thyromegaly and neck pain at presentation; however, the diagnosis of fungal thyroiditis was only established at autopsy (4). In the third case (5), Aspergillus fumigatus hyphae were shown in fine‐needle aspiration (FNA) of the thyroid gland. Lastly, Elzi et al (6) reported a case in which FNA of the thyroid yielded A. fumigatus .…”

mentioning

confidence: 99%

“…Aspergillus thyroiditis is the most common type of fungal thyroiditis reported to date. To the best of our knowledge, only 4 cases of Aspergillus thyroiditis in renal transplant recipients are reported in the literature (3–6). In the first case, no symptoms such as pain in the anterior neck or hyperthyroid features were present (3).…”

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confidence: 99%

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Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis

Solak¹,

Atalay²,

Nar³

et al. 2010

Transplant Infectious Dis

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Fungal pathogens are increasingly encountered after renal transplantation. Aspergillus causes significant morbidity and mortality in transplant patients. Fungal thyroiditis is a rare occurrence owing to unique features of the thyroid gland. Most cases are caused by Aspergillus species and have been described in immunocompromised patients. Presentation may be identical with that of subacute thyroiditis, in which hyperthyroidism features and painful thyroid are the prominent findings. Diagnosis can be ascertained by fine-needle aspiration of thyroid showing branching hyphae of Aspergillus. We describe a renal transplant patient who developed Aspergillus thyroiditis as part of a disseminated infection successfully treated with voriconazole.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Aspergillus thyroiditis in a renal transplant recipient mimicking subacute thyroiditis

Solak¹,

Atalay²,

Nar³

et al. 2010

Transplant Infectious Dis

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“…We performed a review of the literature of the cases reported with Aspergillus thyroiditis in patients over 18 years of age in the medical literature published during 1980–2012 through a search of the PubMed database [4, 7–13, 21–34]. Here, we only report those cases where the diagnosis was able to be corroborated antemortem by fine needle aspiration (FNA) cytology (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Rapidly Growing Thyroid Mass in an Immunocompromised Young Male Adult

Santiago

Martinez

Palermo

et al. 2013

Case Reports in Endocrinology

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We describe a 20-year-old man diagnosed with a myelodysplastic syndrome (MDS), admitted to our hospital due to pancytopenia and fever of undetermined origin after myelosuppression with chemotherapy. Disseminated aspergillosis (DIA) was suspected when he developed skin and lung involvement. A rapidly growing mass was detected on the left neck area, during hospitalization. A thyroid ultrasound reported a 3.7 × 2.5 × 2.9 cm oval heterogeneous structure, suggestive of an abscess versus a hematoma. Fine needle aspiration of the thyroid revealed invasion of aspergillosis. Fungal thyroiditis is a rare occurrence. Thyroid fungal infection is difficult to diagnose; for this reason it is rarely diagnosed antemortem. To our knowledge, this is the 10th case reported in the literature in an adult where the diagnosis of fungal invasion to the thyroid was able to be corroborated antemortem by fine needle aspiration biopsy.

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