Aspergillus thyroiditis: a review of the literature to highlight clinical challenges

Nguyen, Jimmy; Manera, Ricarchito; Minutti, Carla

doi:10.1007/s10096-012-1704-9

Cited by 19 publications

(21 citation statements)

References 29 publications

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“…Fungal thyroiditis is a rare entity among cases of suppurative thyroiditis. Aspergillus is the most common cause, followed by Candida [ 4 ]. Fungal thyroiditis is detected in immunocompromised patients during disseminated Aspergillus infections.…”

Section: Discussionmentioning

confidence: 99%

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AspergillusThyroiditis after Allogeneic Hematopoietic Stem Cell Transplantation

Ataca

Atilla

Saracoglu

et al. 2015

Case Reports in Hematology

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Aspergillus thyroiditis is a rare disorder detected in immunocompromised patients during disseminated infections. Early management is essential to prevent high mortality. A 61-year-old allogeneic stem cell male recipient presented with painful thyroid nodular enlargement. He had low TSH and low free T4 levels. The thyroid ultrasound showed a hypoechoic nodule; biopsy indicated suppurative Aspergillus thyroiditis. He was successfully treated by amphotericin B.

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Section: Discussionmentioning

confidence: 99%

“…The diagnosis of fungal thyroiditis is challenging, and over 50% of patients present with clinical and laboratory symptoms of thyroid dysfunction [ 4 ]. Fever, neck pain, thyroid enlargement, dyspnea, and dysphonia are the most common symptoms.…”

Section: Discussionmentioning

confidence: 99%

AspergillusThyroiditis after Allogeneic Hematopoietic Stem Cell Transplantation

Ataca

Atilla

Saracoglu

et al. 2015

Case Reports in Hematology

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“…The most common presenting symptoms of AT are fever and thyroid tenderness or neck pain, while the most threatening involve risk of airway compression and/or esophageal obstruction . AT may be difficult to distinguish from subacute thyroiditis only by thyroid function tests, especially in patients with no signs or symptoms of disseminated invasive aspergillosis .…”

Section: Discussionmentioning

confidence: 99%

Aspergillus thyroiditis: first antemortem case diagnosed by fine‐needle aspiration culture in a pediatric stem cell transplant patient

Badawy

Becktell

Muller

et al. 2015

Transplant Infectious Dis

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Aspergillus thyroiditis (AT) has historically been considered a postmortem diagnosis in immunocompromised patients; most have disseminated disease. This report summarizes the clinical challenge of diagnosing AT. It also highlights the value of the early use of thyroid fine-needle aspiration culture and the need for a high index of suspicion to reach the final diagnosis before disease dissemination.

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“…is difficult to diagnose; since more than 50% of patients do not exhibit clinical or laboratory manifestations of thyroid dysfunction [5]. Thyroid involvement by Aspergillus was found at autopsy as part of disseminated aspergillosis in 11 (46%) of 24 patients without clinical manifestations and laboratory evidence of thyroid dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…are the predominant causative fungus for thyroiditis and asymptomatic thyroid infiltration [2–4]. Aspergillus thyroiditis (AT) has primarily been a postmortem diagnosis on immunocompromised patients with diagnosed disseminated invasive Aspergillosis (DIA) [5, 6]. Reports of antemortem diagnosis are rare, and for this reason in the literature it is difficult to find reports of surviving patients.…”

Section: Introductionmentioning

confidence: 99%

Rapidly Growing Thyroid Mass in an Immunocompromised Young Male Adult

Santiago

Martinez

Palermo

et al. 2013

Case Reports in Endocrinology

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We describe a 20-year-old man diagnosed with a myelodysplastic syndrome (MDS), admitted to our hospital due to pancytopenia and fever of undetermined origin after myelosuppression with chemotherapy. Disseminated aspergillosis (DIA) was suspected when he developed skin and lung involvement. A rapidly growing mass was detected on the left neck area, during hospitalization. A thyroid ultrasound reported a 3.7 × 2.5 × 2.9 cm oval heterogeneous structure, suggestive of an abscess versus a hematoma. Fine needle aspiration of the thyroid revealed invasion of aspergillosis. Fungal thyroiditis is a rare occurrence. Thyroid fungal infection is difficult to diagnose; for this reason it is rarely diagnosed antemortem. To our knowledge, this is the 10th case reported in the literature in an adult where the diagnosis of fungal invasion to the thyroid was able to be corroborated antemortem by fine needle aspiration biopsy.

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Aspergillus thyroiditis: a review of the literature to highlight clinical challenges

Cited by 19 publications

References 29 publications

AspergillusThyroiditis after Allogeneic Hematopoietic Stem Cell Transplantation

AspergillusThyroiditis after Allogeneic Hematopoietic Stem Cell Transplantation

Aspergillus thyroiditis: first antemortem case diagnosed by fine‐needle aspiration culture in a pediatric stem cell transplant patient

Rapidly Growing Thyroid Mass in an Immunocompromised Young Male Adult

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