Unchanged fasting and postprandial adiponectin levels following a 4‐day caloric restriction in young healthy men

Imbeault, Pascal; Pomerleau, Marjorie; Harper, Mary‐Ellen; Doucet, Éric

doi:10.1111/j.1365-2265.2004.01997.x

Cited by 42 publications

(34 citation statements)

References 23 publications

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“…The unchanged plasma adiponectin in R cows compared with the C cows indicates that its circulating concentration is not affected by energy balance. The finding of unchanged adiponectin concentrations during feed restriction agrees with results of energy restriction (4 d) study in humans (Imbeault et al, 2004) and total feed deprivation studies in rodents (48 h of fasting; Combs et al, 2003;Kmiec et al, 2005) and humans (48 to 72 h of fasting; Gavrila et al, 2003;Merl et al, 2005). However, another report suggests that adiponectin concentration is decreased in mice after 8 h of fasting (Gui et al, 2003).…”

supporting

confidence: 78%

Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows

Singh

Häußler

Gross

et al. 2014

Journal of Dairy Science

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Adiponectin, one of the most abundant adipokines in circulation, is known for its role in regulation of body metabolism. The aim of this study was to evaluate the effects of a negative energy balance (NEB) at 2 stages of lactation (lactational NEB at the onset of lactation and an induced NEB by feed restriction near 100 d of lactation) on circulating adiponectin concentrations. We also investigated the effect of feed restriction on adiponectin concentrations in milk and the relationships of blood and milk adiponectin with selected plasma or milk variables and with measures of body condition. Plasma adiponectin was measured in 50 multiparous Holstein dairy cows throughout 3 experimental periods [i.e., period 1 = 3 wk antepartum up to 12 wk postpartum, period 2 = 3 wk of feed restriction starting at around 100 d in milk with a control (n = 25) and feed-restricted group (50% of energy requirements; n = 25), and period 3 = subsequent realimentation period for 8 wk]. Milk adiponectin was investigated among 21 multiparous cows at wk 2 and wk 12 of period 1 and wk 2 of period 2. Adiponectin concentrations in plasma and skim milk were measured using an in-house ELISA specific for bovine adiponectin. Major changes in circulating adiponectin concentrations were observed during the periparturient period, whereas energy deficiency during established lactation at around 100 d in milk and subsequent refeeding did not affect plasma adiponectin. Together with lower adiponectin concentrations in milk (μg/mL), the reduction in milk yield led to decreased adiponectin secretion via milk (mg/d) at the second week of feed restriction. Irrespective of time and treatment, milk adiponectin represented about 0.002% of total milk protein. Mean adiponectin concentrations in milk (0.61 ± 0.03 μg/mL) were about 92% lower than the mean plasma adiponectin concentrations (32.1 ± 1.0 μg/mL). The proportion of the steady-state plasma adiponectin pool secreted daily via milk was 2.7%. In view of the similar extent of NEB in both periods of energy deficiency, decreasing adiponectin concentrations seems important for accomplishing the adaptation to the rapidly increasing metabolic rates in early lactation, whereas the lipolytic reaction toward feed restriction-induced NEB during established lactation seems to occur largely independent of changes in circulating adiponectin. Key words: adiponectin , milk , energy deficiency , dairy cow Short CommunicationWith the onset of lactation in high-producing dairy cows, milk synthesis leads to an approximately 4-fold increase in total energy requirements compared with pregnant and nonlactating state (Block et al., 2001), which is often accompanied by insufficient voluntary feed intake. The period of negative energy balance (NEB) is associated with changes in several metabolic key hormones, such as growth hormone and IGF-1, and the responsiveness of peripheral tissues for these hormones (Rhoads et al., 2007). The period of energy demand such as early lactation in dairy cattle is characterized by an incr...

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supporting

confidence: 78%

Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows

Singh

Häußler

Gross

et al. 2014

Journal of Dairy Science

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“…We were interested in determining whether adiponectin decreased during fasting and whether a change in adiponectin promoted alterations in insulin action. Others have reported that 4 days of caloric restriction (25) or 72 h of fasting (6) did not change basal adiponectin concentration in lean men. Similarly, we found that basal adiponectin concentration did not change with 48 h of fasting in lean men and women (Fig.…”

Section: Discussionmentioning

confidence: 96%

Effects of fasting on insulin action and glucose kinetics in lean and obese men and women

Bergman

Cornier²,

Horton³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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The development of insulin resistance in the obese individual could impair the ability to appropriately adjust metabolism to perturbations in energy balance. We investigated a 12- vs. 48-h fast on hepatic glucose production (R(a)), peripheral glucose uptake (R(d)), and skeletal muscle insulin signaling in lean and obese subjects. Healthy lean [n = 14; age = 28.0 +/- 1.4 yr; body mass index (BMI) = 22.8 +/- 0.42] and nondiabetic obese (n = 11; age = 34.6 +/- 2.3 yr; BMI = 36.1 +/- 1.5) subjects were studied following a 12- and 48-h fast during 2 h of rest and a 3-h 40 mUxm(-2)xmin(-1) hyperinsulinemic-euglycemic clamp (HEC). Basal glucose R(a) decreased significantly from the 12- to 48-h fast (lean 1.96 +/- 0.23 to 1.63 +/- 0.15; obese 1.23 +/- 0.07 to 1.07 +/- 0.07 mgxkg(-1)xmin(-1); P = 0.004) and was equally suppressed during the HEC after both fasts. The increase in glucose R(d) during the HEC after the 12-h fast was significantly decreased in lean and obese subjects after the 48-h fast (lean 9.03 +/- 1.17 to 4.16 +/- 0.34, obese 6.10 +/- 0.77 to 3.56 +/- 0.30 mgxkg FFM(-1)xmin(-1); P < 0.001). After the 12- but not the 48-h fast, insulin-stimulated AKT Ser(473) phosphorylation was greater in lean than obese subjects. We conclude that 1) 48 h of fasting produces a marked decline in peripheral insulin action, while suppression of hepatic glucose production is maintained in lean and obese men and women; and 2) the magnitude of this decline is greater in lean vs. obese subjects.

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“…95 In men, similarly, adiponectin levels were unchanged following consumption of an 800 kcal/day diet for four days. 96 We have observed a modest (ϳ10%) but significant increase in serum adiponectin in normal-weight women following consumption of a calorie-restricted (600 kcal/day) diet for one week; interestingly, the opposite effect (an ϳ20% decrease of adiponectin) was observed in men restricted to 800 kcal/day. 97 One study of healthy normal-weight women restricted to 1000 to 1200 kcal/day for four weeks showed a significant reduction in adiponectin concentrations (16%), despite an average weight loss of 3.4 kg.…”

Section: Effects Of Caloric Restriction and Weight Loss On Circulatinmentioning

confidence: 93%

Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans

Swarbrick

Havel

2008

Metabolic Syndrome and Related Disorders

219

176

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Adiponectin is an adipocyte hormone that links visceral adiposity with insulin resistance and atherosclerosis. It is unique among adipocyte-derived hormones in that its circulating concentrations are inversely proportional to adiposity, and low adiponectin concentrations predict the development of type 2 diabetes and cardiovascular disease. Consequently, in the decade since its discovery, adiponectin has generated immense interest as a potential therapeutic target for the metabolic syndrome and diabetes. This review summarizes current research regarding the regulation of circulating adiponectin concentrations by physiological, pharmacological, and nutritional factors, with an emphasis on human studies. In humans, plasma adiponectin concentrations are influenced by age and gender, and are inversely proportional to visceral adiposity. In vitro studies suggest that adiponectin production may be determined primarily by adipocyte size and insulin sensitivity, with larger, insulin-resistant adipocytes producing less adiponectin. While adiponectin concentrations are unchanged after meal ingestion, they are increased by significant weight loss, such as after bariatric surgery. In addition, adiponectin production is inhibited by a number of hormones, including testosterone, prolactin, glucocorticoids and growth hormone, and by inflammation and oxidative stress in adipose tissue. Smoking decreases, while moderate alcohol consumption increases, circulating adiponectin concentrations. Dietary fatty acid composition in rodents influences adiponectin production via ligand-activated nuclear receptors (PPARs); however, current evidence in humans is equivocal. In addition to PPAR agonists (such as thiazolidinediones and fibrates), a number of pharmacological agents (angiotensin receptor type 1 blockers, ACE inhibitors, and cannabinoid receptor antagonists) used in treatment of the metabolic syndrome also increase adiponectin concentrations in humans.

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Unchanged fasting and postprandial adiponectin levels following a 4‐day caloric restriction in young healthy men

Abstract: Fasting and postprandial adiponectin levels are not acutely modulated by a short-term energy restriction in young healthy men.

Cited by 42 publications

References 23 publications

Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows

Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows

Effects of fasting on insulin action and glucose kinetics in lean and obese men and women

Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans

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