“…Since the duration of these bubbles is greater than the time necessary to vary the frequency of the ultrasounds generated, it is possible to obtain the effect of cavitation that is the expansion and collapse of the bubbles, at different times. The lower frequency field nucleates larger bubbles while the higher frequency field, subsequently applied, creates the cavitation effect with the consequent growth and implosion of the bubbles obtaining a greater efficacy in the treatment of calcium deposits than the use of a single frequency [17][18][19][20]. The PZT, are introduced by a catheter, with an outer diameter of 6 mm, designed for access via a femoral artery, reaching the leaflets of the aortic valve.…”