Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study

Sundvall, Linda; Kirkegaard, Kirstine; Ingerslev, Hans Jakob; Knudsen, Ulla Breth

doi:10.1007/s10815-015-0488-0

Cited by 26 publications

(18 citation statements)

References 66 publications

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“…Previous studies suggested that impaired oocyte and embryo quality could be a concern for decreased reproductive outcomes in women with PCOS (Dumesic and Abbott, 2008;Qiao and Feng, 2011). However, some studies found that there was no causative factor of the pre-implantation embryo for subfertility in PCOS (Sundvall et al, 2015). Our study results showed that the fertilization rate and numbers of viable embryos were comparable between the two groups.…”

Section: Discussionsupporting

confidence: 49%

Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study

Luo

Jie

et al. 2017

Reproductive BioMedicine Online

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The early miscarriage rate is reported to be higher in patients with polycystic ovary syndrome (PCOS) compared with non-PCOS patients. However, whether PCOS is an independent risk factor for early miscarriage is still controversial; to what extent embryonic aneuploidy accounts for miscarriages of PCOS is still unknown. In this 1:3 matched-pair study, 67 lean PCOS patients and 201 controls matched for age, body mass index (BMI) and embryo scores undergoing a single euploid blastocyst transfer in vitrified-warmed cycles were analysed. Clinical pregnancy, early miscarriage and live birth rates were compared. Logistic regression analysis was performed to further evaluate the factors associated with early miscarriage and live birth. Clinical pregnancy rates were 50.7% in PCOS and 55.2% in control groups. Early miscarriage rate was significantly (P = 0.029) increased in the PCOS group compared with controls; non-PCOS patients had a significantly higher live birth rate than PCOS patients, P < 0.001. Further regression analyses showed that PCOS was significantly associated with a higher risk of early miscarriage and decreased chance of live birth. In conclusion, PCOS in women undergoing pre-implantation genetic diagnosis may, independently from BMI and karyotype, increase the risk of miscarriage.

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Section: Discussionsupporting

confidence: 49%

Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study

Luo

Jie

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

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“…The authors believe that predictive models can be very useful, in the first instance for de-selection of embryos undergoing abnormal cleavage events such as direct cleavage and reverse cleavage shown to have a significantly reduced chance of creating a pregnancy (Rubio et al, 2012;Liu et al, 2014) but also, if developed effectively, to select the best embryo from a cohort for a specific patient demographic. Patient characteristics including infertility diagnosis (Sundvall et al,2015) and maternal age (Hampl and Stephan, 2013;Chawla et al, 2015) as well as treatment characteristics including treatment type and culture conditions (Lemmen et al, 2008;Wale and Gardner, 2010;Cirayet al, 2012;Cruz et al, 2013;Kirkegaard et al, 2013b) have been shown to affect an embryo's morphokinetic profile and the resulting subtle differences may be used to identify which embryo has the highest implantation potential. Herein lies a further reason for possible variation in success of TLS between laboratories; patient and treatment characteristics.…”

Section: Discussionmentioning

confidence: 99%

Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis

et al. 2016

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“…The present paper presents a multivariate analysis of development in the embryos from 243 patients. Previous publications on the same cohort or subgroups of the cohort have reported on the correlation between early time-lapse parameters and embryo development ( Kirkegaard et al , 2013b ), correlation between metabolism and clinical outcome ( Kirkegaard et al , 2014b ) and development of embryos from women with polycystic ovary syndrome ( Sundvall et al , 2015 ).…”

Section: Methodsmentioning

confidence: 99%

Timing of human preimplantation embryonic development is confounded by embryo origin

et al. 2015

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STUDY QUESTIONTo what extent do patient- and treatment-related factors explain the variation in morphokinetic parameters proposed as embryo viability markers?SUMMARY ANSWERUp to 31% of the observed variation in timing of embryo development can be explained by embryo origin, but no single factor elicits a systematic influence.WHAT IS KNOWN ALREADYSeveral studies report that culture conditions, patient characteristics and treatment influence timing of embryo development, which have promoted the perception that each clinic must develop individual models. Most of the studies have, however, treated embryos from one patient as independent observations, and only very few studies that evaluate the influence from patient- and treatment-related factors on timing of development or time-lapse parameters as predictors of viability have controlled for confounding, which implies a high risk of overestimating the statistical significance of potential correlations.STUDY DESIGN, SIZE, DURATIONInfertile patients were prospectively recruited to a cohort study at a hospital fertility clinic from February 2011 to May 2013. Patients aged <38 years without endometriosis were eligible if ≥8 oocytes were retrieved. Patients were included only once. All embryos were monitored for 6 days in a time-lapse incubator.PARTICIPANTS/MATERIALS, SETTING, METHODSA total of 1507 embryos from 243 patients were included. The influence of fertilization method, BMI, maternal age, FSH dose and number of previous cycles on timing of t2-t5, duration of the 2- and 3-cell stage, and development of a blastocoel (tEB) and full blastocoel (tFB) was tested in multivariate, multilevel linear regression analysis. Predictive parameters for live birth were tested in a logistic regression analysis for 223 single transferred blastocysts, where time-lapse parameters were investigated along with patient and embryo characteristics.MAIN RESULTS AND THE ROLE OF CHANCEModerate intra-class correlation coefficients (0.16–0.31) were observed for all parameters except duration of the 3-cell stage, which demonstrates that embryos from one patient elicit clustering at a patient level. No single patient- and treatment-related factor was found to systematically influence the timing from cleavage to blastocyst stage, which indicates that no individual patient-related factor can be identified that separately explains the clustering throughout the entire developmental stages. The blastocyst parameters were more affected by patient-related factors than cleavage stage parameters, as tEB occurred significantly later with older age (0.29 h/year (95% confidence interval: CI 0.03; 0.56)), while both tEB and tFB occurred significantly later with increasing dose of FSH (tEB: 0.12 h/100 IU FSH (95% CI 0.01;0.24); tFB 0.14 h/100 IU FSH (95% CI 0.03;0.27)) and with more previous attempts (tEB: 1.2 h/attempt (95% CI 0.01;2.5); tFB 1.4 h/attempt (0.10;2.7)). Fertilization method affected timing of the first division, with ICSI embryos cleaving significantly faster than IVF embryos (−3.6% (95% CI −6....

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Unaltered timing of embryo development in women with polycystic ovarian syndrome (PCOS): a time-lapse study

Abstract: The findings suggest that the causative factor for subfertility in PCOS is not related to timing of development in the pre-implantation embryo.

Cited by 26 publications

References 66 publications

Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study

Early miscarriage rate in lean polycystic ovary syndrome women after euploid embryo transfer – a matched-pair study

Embryos cultured in a time-lapse system result in superior treatment outcomes: a strict matched pair analysis

Timing of human preimplantation embryonic development is confounded by embryo origin

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