Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment

Marcusson, Jan; Bäckström, Inger T.; Ross, Svante B.

doi:10.1007/bf00176844

Cited by 10 publications

(1 citation statement)

References 12 publications

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“…vary with regard to the uptake inhibitor and dose utilized as well as the duration of treatment and the withdrawal interval. However, chronic treatment with selective 5-HT uptake inhibitors (e.g., chlorimipramine, fluoxetine, fluvoxamine) generally decreased (Brunello et al, 1987;Hrdina, 1987;Montero et al, 1990) or had no effect (Marcusson et al, 1988) on L3Hlimipramine binding to crude synaptic preparations from rat brain. Similar repeated exposure to selective 5-HT uptake inhibitors, such as citalopram, indalpine, and zimelidine, decreased the sensitivity of 5-HT DR neurons to 5-HT and 5-HTIA autoreceptor agonists (Blier and de Montigny, 1983;Blier et al, 1984;1988;Chaput et al, 1986), although alterations in response to a 5-HT uptake inhibitor as described here has not yet been assessed.…”

Section: Scheelmentioning

confidence: 98%

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

Cunningham

Paris

Goeders

1992

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150

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Repeated cocaine intoxication can result in the development of behavioral sensitization in animals and psychosis in humans, phenomena that have been associated with alterations in dopamine (DA) function. Using electrophysiologic and autoradiographic techniques, modifications of central serotonin (5-hydroxytryptamine; 5-HT) systems were investigated in rats treated with a regimen of cocaine administration that produced behavioral sensitization. The inhibitory response of single 5-HT neurons in the dorsal raphe (DR) to (-)-cocaine, the 5-HT uptake inhibitor fluoxetine or the 5-HT1A agonist 8-hydroxy-2-[di-N-propylamino]tetralin (8-OHDPAT) was significantly enhanced in cocaine-treated rats. Furthermore, several brain areas that contain either cell bodies (DR) or terminals for 5-HT (medial and sulcal prefrontal cortex, frontal cortex) showed cocaine-induced elevations in [3H]imipramine-labeled 5-HT uptake sites, while [3H]-8-OHDPAT-labeled 5-HT1A receptors were decreased only in the central medial amygdala. These results suggest that modifications of autoregulatory mechanisms secondary to alterations of 5-HT uptake processes may contribute to the development of cocaine sensitization.

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Section: Scheelmentioning

confidence: 98%

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

Cunningham

Paris

Goeders

1992

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150

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Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs

et al. 1990

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Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg, d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls.

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Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets

Marcusson

Ross

1990

Psychopharmacology

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Antidepressant agents with properties to inhibit 5-hydroxytryptamine (5-HT, serotonin) uptake in brain tissue and platelets bind with high affinities to neuronal and platelet membranes. [3H]Imipramine, [3H]paroxetine and [3H]citalopram label specific binding sites related to the 5-HT transporter. [3H]Paroxetine and [3H]citalopram appear to be better ligands than [3H]imipramine. The former label a homogenous population of binding sites, whereas the displaceable binding of [3H]imipramine is heterogenous. Recent observations in several laboratories, which have taken the heterogeneity of [3H]imipramine binding into account, indicate that the binding of antidepressants to the 5-HT transporter probably occurs to the same site that binds 5-HT for transport and not to a separate site as previously suggested. Additional bonds to subsites in close vicinity to the 5-HT recognition site may contribute to the binding. No convincing evidence has been presented of the existence of an endogenous ligand other than 5-HT itself that binds to the [3H]imipramine binding site. Recent studies also suggest that repeated treatment of rats with antidepressant agents does not produce any alterations of the binding of [3H]imipramine or [3H]paroxetine to membranes of cerebral cortex. It is also doubtful whether the density of the 5-HT uptake site in platelets measured with these ligands is decreased in affective disorders as first reported.

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Unaltered 5-HT- and desipramine-sensitive [3H]imipramine binding and [3H]5-HT uptake in rat brain after chronic imipramine and norzimeldine treatment

Cited by 10 publications

References 12 publications

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs

Binding of some antidepressants to the 5-hydroxytryptamine transporter in brain and platelets

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