Umblical metastasis in cervical cancer

Abstract

Introduction Objective cutaneous metastasis from carcinoma of the uterine cervix is an uncommon occurrence. The outcome of patients with skin metastasis is usually poor as they are often associated with locoregional recurrence. This metastasis impairs the quality of life and shortens survival. Consequently, physicians should be aware of the possible existence of skin metastasis in cervical cancer. Clinical suspicion should lead to a careful additional evaluation whenever a cutaneous nodule presents in the course of the disease. Case report We report a rare case of metastasis from squamous cell carcinoma of cervix to the umbilicus. The patient was diagnosed with stage IIB FIGO. Four months after chemoradiation patient presented with a nodule in the umbilical region. Biopsy performed and metastatic squamous cell carcinoma was diagnosed. Patient underwent salvage therapy with paclitaxel and carboplatin. Conclusion To the best of our knowledge, this is a rare reported occurrence of umbilical metastasis in cervical cancer without prior laparotomy or laparoscopy. This metastatic lesion has a grave prognosis and the mean survival is about 3 months like our case.

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

“…This case, however, is distinctive for several reasons. First, in prior reports of cutaneous metastases from cervical squamous cell carcinoma, the grossly visible nodules are usually single or a small cluster of multiple papules [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . In our patient's case, the cutaneous metastases were innumerable and located diffusely over the anterior abdominal wall, vulva, perineum, and bilateral proximal lower extremities (see Figure 1).…”

“…This clinical scenario is even less common in literature originating from the United States, due to the lower overall incidence of cervical cancer [3][4][5] . Case reports have documented various sites of cutaneous metastases, including the face and neck [6] , scalp [7][8][9] , vulva [5,[10][11] , upper and lower extremities [12][13] , umbilicus (Sister Mary Joseph nodule) [14] , trunk/abdominal wall [3][4][5]15] , and surgical incision/drain sites [16][17] . Prior authors have found that the occurrence of metastases to the skin generally implies terminal disease, with the average survival following diagnosis ranging from 3-6 months, even in cases where palliative chemo-and radiotherapy are administered [15] .…”

Paraneoplastic Dermatoses Associated With Gynecologic and Breast Malignancies

“…In a retrospective chart review of 220 patients with epithelial ovarian carcinoma, the average time of appearance of skin metastases after the diagnosis of ovarian cancer was 23.4 Ϯ 12 months, with an overall mean survival after diagnosis of skin metastasis being 4 months (37). Cutaneous metastases of cervical cancer (38) and endometrial cancer (39) is rarely observed.…”

Cancer Cervix With Skin Metastasis - A Case Report With Review of Literature

“…To date, no effective treatment has been identified. Treatment is nearly always palliative, and consists of using radiation, chemotherapy, or surgery, either alone or in 12,13 combination.…”