Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain

Kimber-Trojnar, Żaneta; Patro-Małysza, Jolanta; Trojnar, Marcin; Darmochwał-Kolarz, Dorota; Oleszczuk, Jan; Leszczyńska‐Gorzelak, Bożena

doi:10.3390/ijms20030595

Cited by 10 publications

(12 citation statements)

References 56 publications

(78 reference statements)

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“…Compared with the healthy study participants, the EGWG mothers presented significantly higher values of body mass index (BMI) at the time of and after delivery, as well as gestational weight and BMI gains, and BMI gain in the period from pre-pregnancy to 48 h after delivery (ΔBMI), but they were of comparable age, had pre-pregnancy BMIs, and BMI loss after delivery. Some of the results regarding the characteristics of the study subjects were previously presented by us [32]. The EGWG women were characterized by increased levels of hemoglobin A1c, triglycerides, total body water (including extracellular (ECW), as well as intracellular (ICW) water), body cell mass, and indexes of fat (FTI) and lean (LTI) tissues, as well as lower concentrations of high-density lipoprotein cholesterol (HDL).…”

Section: Resultsmentioning

confidence: 99%

Vaspin in Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain

et al. 2019

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Background and objectives: Data concerning vaspin in obstetric aspects are limited and conflicting. The aim of the study was to evaluate vaspin concentrations in the serum and urine of women with excessive gestational weight gain (EGWG) in the early post-partum period (i.e., 48 h after delivery), when placental function no longer influences the results. Materials and Methods: The study subjects were divided into two groups of 28 healthy controls and 38 mothers with EGWG. Maternal body composition and hydration status were evaluated by the bioelectrical impedance analysis (BIA) method. Concentrations of vaspin, fatty acid-binding protein 4 (FABP4), leptin, and ghrelin were determined via enzyme-linked immunosorbent assay (ELISA). Results: Serum vaspin levels were lower in the EGWG group, whereas no significant differences were noted between the groups, with regard to the urine vaspin concentrations. In both studied groups, the serum vaspin concentrations correlated positively with the urine FABP4 levels and negatively with gestational weight gain, body mass index gain in the period from pre-pregnancy to 48 h after delivery (ΔBMI), and fat tissue index (FTI). In the multiple linear regression models, the serum vaspin concentrations were positively dependent on the serum FABP4 levels, as well as negatively dependent on triglycerides, FTI, and ΔBMI. Conclusions: Our study revealed that the EGWG mothers were characterized by significantly lower serum vaspin concentrations in the early post-partum period compared with the subjects that had appropriate gestational weight gain. Our observation supports previous hypotheses that vaspin might be used as a marker of lipid metabolism in pregnancy and maternal adipose tissue. Considering the fact that FABP4 is widely referred to as a pro-inflammatory adipokine, further research on the protective role of vaspin seems crucial, especially in the context of its relationship to FABP4.

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Section: Resultsmentioning

confidence: 99%

Vaspin in Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain

et al. 2019

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“…EGWG subjects also had lower Sfrp5 concentrations than the control group. These findings suggest an early exposure of the developing fetus to an imbalance of these adipokines and the subsequent development of metabolic complications [ 92 ].…”

Section: Children and Adolescentsmentioning

confidence: 99%

The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and Lifestyle

et al. 2021

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In recent decades, the prevalence of obesity has risen dramatically worldwide among all age groups. Obesity is characterized by excess fat accumulation and chronic low-grade inflammation. The adipose tissue functions as a metabolically active endocrine organ secreting adipokines. A novel duo of adipokines, the anti-inflammatory secreted frizzled-related protein 5 (Sfrp5) and the proinflammatory wingless type mouse mammary tumor virus (MMTV) integration site family member 5A (Wnt5a), signal via the non-canonical Wnt pathway. Recent evidence suggests that Sfpr5 and Wnt5a play a key role in the pathogenesis of obesity and its metabolic complications. This review summarizes the current knowledge on the novel regulatory system of anti-inflammatory Sfrp5 and pro-inflammatory Wnt5a, and their relation to obesity and obesity-related complications. Future studies are required to investigate the potential role of Sfrp5 and Wnt5a as biomarkers for monitoring the response to lifestyle interventions and for predicting the development of cardiometabolic risk factors. These adipokines may also serve as novel therapeutic targets for obesity-related disorders.

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“…We hypothesize that these differences can be connected to disparities in body composition and hydration status. Our previous study revealed that mothers with EGWG were characterized by increased fat and lean tissues in the bioelectrical impedance analysis [22]. Unfortunately, the evaluation of these parameters seems to not be feasible in the case of newborns.…”

Section: Discussionmentioning

confidence: 99%

“…In the cited study we compared women diagnosed with gestational diabetes mellitus (GDM) with the aforementioned control group [37]. The cohort analyzed in the present study was used to measure SFRP5 and was described in our previous study [22]. Comparative characteristics of the study groups are presented in Tables S1 and S2.…”

Section: Methodsmentioning

confidence: 99%

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Skórzyńska-Dziduszko

et al. 2019

IJMS

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Two-thirds of pregnant women exceed gestational weight gain recommendations. Excessive gestational weight gain (EGWG) appears to be associated with offspring’s complications induced by mechanisms that are still unclear. The aim of this study was to investigate whether umbilical cord leptin (UCL) and ghrelin (UCG) concentrations are altered in full-term neonates born to EGWG mothers and whether neonatal anthropometric measurements correlate with UCL and UCG levels and maternal serum ghrelin and leptin as well as urine ghrelin concentrations. The study subjects were divided into two groups, 28 healthy controls and 38 patients with EGWG. Lower UCL and UCG levels were observed in neonates born to healthy mothers but only in male newborns. In the control group UCG concentrations correlated positively with neonatal birth weight, body length and head circumference. In the control group maternal serum ghrelin levels correlated negatively with neonatal birth weight, body length and head circumference as well as positively with chest circumference. In the EGWG group UCG concentrations correlated negatively with neonatal birth weight and birth body length. UCL correlated positively with birth body length in EGWG group and negatively with head circumference in the control group. In conclusion, EGWG is associated with disturbances in UCL and UCG concentrations.

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Umbilical Cord SFRP5 Levels of Term Newborns in Relation to Normal and Excessive Gestational Weight Gain

Cited by 10 publications

References 56 publications

Vaspin in Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain

Vaspin in Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain

The Emerging Role of Sfrp5 and Wnt5a in the Pathogenesis of Obesity: Implications for a Healthy Diet and Lifestyle

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

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