Umbilical cord nucleated red blood cell counts: normal values and the effect of labor

McCarthy, Joan M.; Capullari, Tammy; Thompson, Z; Zhu, Yiliang; Spellacy, William N.

doi:10.1038/sj.jp.7211437

Cited by 46 publications

(34 citation statements)

References 23 publications

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“…Our results only correlate with the results of Boskabadi et al [7] who carried out a study on 48 perinatally asphyxiated neonates and the most common mode of delivery was normal vaginal route in 34 of these babies. In a study by McCarthy et al [8] concluded that stress of uncomplicated labor does not change NRBC levels. Thus the variation in different studies regarding the mode of delivery may be explained by the fact that neonatal encephalopathy may originate early in neonatal period in some cases of HIE.…”

Section: Discussionmentioning

confidence: 99%

Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Colaco¹

2014

Int J Clin Pediatr

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Section: Discussionmentioning

confidence: 99%

Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Colaco¹

2014

Int J Clin Pediatr

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“…20 The increased erythropoiesis is probably due to both an increase in erythropoietin levels and a direct hemopoietic effect of hyperinsulinaemia. [21][22][23] The importance of estimation of alkali resistant hemoglobin cannot be over emphasized in a resource poor country like India which also has the dubious distinction of having a prevalence of thalassemia. 24,25 While majority of the hemoglobin in the fetus is alkali resistant, the proportion rapidly decreases in the first year of life.…”

Section: Discussionmentioning

confidence: 99%

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

2016

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Background: The importance of complete hemogram along with the hematological indices in the diagnosis of neonatal health cannot be overemphasized. There is a severe paucity of relevant data regarding neonatal hematological profile in relation to gestational age and maternal diseases in this part of the country. With this perspective, the authors intended to do a pilot study to analyse the haematological profile of neonates of different gestational ages and different maternal diseases born in a teriary care hospital in Eastern India.Methods: This is a cross sectional study design based on cord blood sample of newborns and their mothers recruited from those admitted in the gynae and obstetric department in IPGME&R. The umbilical cord blood was collected from the newborn babies and then examined for different haematological parameters. The data obtained was statistically analysed.Results: While there has been a sequential rise of fetal red cell count, hemoglobin and the total white cell count neutrophils with gestational age, the mean corpuscular cell volume decreased. All these values were comprised to varying degrees in maternal diseases except for nucleated rell blood cells which conspicuously increased in neonates of diabetic mothers.Conclusions: In this study, a small attempt was made to assess the haematological profile (including alkali resistant hemoglobin) of the newborns in relation to gestational age and maternal diseases in the population attending a tertiary care hospital in Eastern India.

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“…Moreover, it has been suggested that increased NRBC count is not only the marker of perinatal asphyxia, but also predicts the risk of consequences of neurological development. 15,21,33,34 Although the exact mechanism is unclear, it may be relevant to increase the umbilical cord blood erythropoietin levels in 1 to 4 hours after acute asphyxia. Increased secretion of erythropoietin results in increased release of NRBCs from the bone marrow due to increased mitotic divisions of normoblasts.…”

Section: Discussionmentioning

confidence: 99%

Nucleated RBCs in umbilical cord blood as marker in cases of fetal asphyxia

Shrivastava

Vagha

Borkar

2017

Int J Contemp Pediatr

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Background: World health organization (WHO) has defined perinatal asphyxia as a failure to initiate and sustain breathing at birth. HIE is one of the most common complication in an asphyxiated neonate because of its serious long term neuromotor sequalae among the survivors. Nucleated red blood cells (NRBC) count in umbilical cord of newborns is been suggested as a sign of birth asphyxia. As the present markers are not accurate in diagnosis and assessing the severity of fetal asphyxia, this study was undertaken to find the values of NRBCs in normal and asphyxiated neonates and the correlation of NRBCs with birth asphyxia.Methods: Eighty neonates with asphyxia along with eight healthy newborns were undertaken for two years study period. Maternal and neonatal information was recorded follow by clinical and laboratory evaluation. NRBC levels was determined per 100 white blood cells (WBC). After discharge, immediate follow-up of asphyxiated infants was performed. Neonates were divided into two groups, with favorable and unfavorable outcome based on discharge or death.Results: We observed that NRBC count with more than 10 per 100 WBC/mm3, had sensitivity of 88.75% and specificity of 100% in predicting complications of asphyxia, while in NRBC count with more than 10, the sensitivity and specificity were 88.75% and of 100%, respectively. Conclusions: We demonstrate that NRBC/100 WBC can be used as prognostic marker for neonatal asphyxia, which in combination with the severity of asphyxia could indicate high infant mortality, immediate outcome and complications of asphyxia

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Umbilical cord nucleated red blood cell counts: normal values and the effect of labor

Cited by 46 publications

References 23 publications

Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Study of Nucleated Red Blood Cell Counts in Asphyxiated Newborns and the Fetal Outcome

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

Nucleated RBCs in umbilical cord blood as marker in cases of fetal asphyxia

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