Umbilical Cord Milking Stabilizes Cerebral Oxygenation and Perfusion in Infants Born before 29 Weeks of Gestation

Takami, Takeshi; Suganami, Yusuke; Sunohara, Daisuke; Kondo, Atsushi; Mizukaki, Norio; Fujioka, Tao; Hoshika, Akinori; Akutagawa, Osamu; Isaka, Keiichi

doi:10.1016/j.jpeds.2012.03.053

Cited by 72 publications

(43 citation statements)

References 28 publications

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“…Two previous studies reported UCM to increase SVC flow in very preterm infants 26 27. One study used historical controls26 and the other measured SVC flow at time points with a wide range up to 12 hours which could increase variability in these measurements 27. In our study, the time range for each echo study time point was strictly 2 hours.…”

Section: Discussionmentioning

confidence: 99%

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

El-Naggar

Simpson

Hussain

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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Section: Discussionmentioning

confidence: 99%

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

El-Naggar

Simpson

Hussain

et al. 2018

Arch Dis Child Fetal Neonatal Ed

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“…We first described that umbilical cord milking reduced the need for red blood cell (RBC) transfusions and improved neonatal adaptation in premature infants. 3,4 Nine studies on umbilical cord milking [5][6][7][8][9][10][11][12][13] have been published in the years following the initial report. However, there is no welldesigned, standardized protocol for umbilical cord milking.…”

Section: Introductionmentioning

confidence: 99%

One-time umbilical cord milking after cord cutting has same effectiveness as multiple-time umbilical cord milking in infants born at <29 weeks of gestation: a retrospective study

et al. 2015

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“…Takami et al [21], in infants born < 29 weeks gestation, reported that UCM increased Hct and rScO 2 at 12, 18, 24, and 36 h after birth compared to a group with ICC. The cFTOE in the UCM group was lower than in the control group at 12, 18, and 24 h. Infants receiving UCM had higher LVO at 12 and 18 h and a higher SVC flow at 3–6 h and 12 h after birth.…”

Section: Discussionmentioning

confidence: 99%

Effect of Delayed Cord Clamping on Cerebral Oxygenation in Very Preterm Infants

et al. 2018

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Background and Objective: The mechanism of reported benefits of delayed cord clamping (DCC) are unclear. We aimed to determine whether DCC compared to immediate cord clamping (ICC) in very preterm infants improves cerebral oxygenation in the first 24 h. Study Design: This is a prospective study of a subset of infants at < 30 weeks of gestation who were randomised to DCC (≥60 s) or ICC (< 10 s) and required an indwelling arterial catheter. Regional cerebral oxygenation (rScO₂), blood pressure, PI, and peripheral saturation were measured and cerebral fractional tissue oxygen extraction (cFTOE) calculated for the following 3 time intervals: 3–6, 6–12, and 12–28 h of age. Functional ultrasound measures including superior vena cava flow, right ventricular output, ductus arteriosus size and shunt and anterior cerebral artery resistive index were determined. Results: The mean (±SD) gestation and birth weight of the 51 study infants were 27 ± 1 weeks and 1,046 ± 241 g respectively. Twenty infants received DCC and 31 received ICC. Baseline demographics were similar between the 2 groups. Comparing DCC and ICC infants, there was no difference in rScO₂ or cFTOE at any time point. Three out of 20 infants did not receive DCC due to clinical concerns. A sensitivity analysis revealed that cord clamping ≥30 s was significantly associated with increased rScO₂ and decreased cFTOE at all 3 time points after adjusting for gestation. Conclusion: Although DCC was not associated with changes in cerebral oxygenation overall, sensitivity analysis suggested a possible effect of an increased rScO₂ and a decreased cFTOE with ≥30 s of DCC.

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Umbilical Cord Milking Stabilizes Cerebral Oxygenation and Perfusion in Infants Born before 29 Weeks of Gestation

Cited by 72 publications

References 28 publications

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

Cord milking versus immediate clamping in preterm infants: a randomised controlled trial

One-time umbilical cord milking after cord cutting has same effectiveness as multiple-time umbilical cord milking in infants born at <29 weeks of gestation: a retrospective study

Effect of Delayed Cord Clamping on Cerebral Oxygenation in Very Preterm Infants

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