“…Umbelliferone (7-hydroxycoumarin) is a simple coumarin found in many plants from the Apiaceae family (Leal, Ferreira, Bezerra, Matos, & Viana, 2000). Umbelliferone reportedly exhibits neuroprotective properties in a chronic unpredictable mild stress-induced rat model of depression (Qin et al, 2017), a rat model of focal cerebral ischaemiareperfusion (Wang, Li, Wang, Fu, & Ma, 2015), and a mouse model of Parkinson's disease (Subramaniam & Ellis, 2013). Additionally, accumulating evidence suggests that umbelliferone activates nuclear factor erythroid-derived 2-like 2 (Nrf2) in various animal models, resulting in upregulation of haem oxygenase-1 (HO-1) and attenuation of excessive inflammatory responses (Hassanein, Mohamed, Shalkami, Khalaf, & Hemeida, 2018;Mahmoud, Germoush, Alotaibi, & Hussein, 2017;Mohamed, Emam, Hassan, & Mogadem, 2014).…”