Extract of <i>Euryale ferox Salisb</i> exerts antidepressant effects and regulates autophagy through the adenosine monophosphate‐activated protein kinase—UNC‐51‐like kinase 1 pathway

Huang, Zhiheng; Huang, Xiaoyan; Wang, Qian; Jiang, Ruizhi; Sun, Guangda; Xu, Yiming; Wu, Qinan

doi:10.1002/iub.1731

Cited by 33 publications

(28 citation statements)

References 47 publications

(85 reference statements)

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“…Fig. 6C and D present the significant effects of treatment on the p-AMPK/aMPK (F (4,21) =17.83, P<0.0001; Fig. 6c) and ulK1-Ser317/ulK1 ratios (F (4,15) =8.596, P=0.0008; Fig.…”

Section: Apigenin Activity Is Mediated Via Ampk/ulk1 Signalingmentioning

confidence: 92%

“…all mice were euthanized by cervical dislocation after the behavioral tests, and the hippocampus samples were promptly collected and placed on ice. The samples were then placed into radioimmunoprecipitation assay buffer (Beyotime institute of Biotechnology) with an enzyme inhibitor (Beyotime Institute of Biotechnology) at 5˚C and rapidly homogenized for western blotting, as previously reported (21,26). Protein concentration was determined colorimetrically by BCA assay (Pierce; Thermo Fisher Scientific, inc.).…”

Section: Tail Suspension Testmentioning

confidence: 99%

“…Mammalian target of rapamycin (mTor)/adenosine monophosphate-activated protein kinase (aMPK) signaling is well known as a classic autophagy-related pathway and is considered to be involved in depression (21,22). The present The antidepressant effects of apigenin are associated with the promotion of autophagy via the mTOR/AMPK/ULK1 pathway study aimed to clarify the underlying mechanisms by which apigenin might ameliorate depressive-like actions in mice, and hypothesized that apigenin might regulate the activity of aMPK or mTor, or both.…”

Section: Introductionmentioning

confidence: 99%

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The antidepressant effects of apigenin are associated with the�promotion of autophagy via the mTOR/AMPK/ULK1 pathway

Zhang

Jiang

et al. 2019

Mol Med Report

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The present study aimed to investigate whether apigenin elicits antidepressant effects in depressant-like mice via the regulation of autophagy. The depressant-like behaviors were established in a chronic restraint stress model. Male BalB/c mice were subjected to restraint stress for 6 h/day for a period of 21 days, and deficits in sucrose preference, tail suspension and forced swim tests were confirmed to be improved following oral apigenin. To investigate the underlining mechanisms, the hippocampal levels of p62 and microtubule-associated protein light chain 3-ii/i (lc3-ii/i) were measured using western blot analysis. The expression levels of lc3-ii/i and p62 indicated that the significantly inhibited autophagy level induced by chronic restraint stress can be increased following apigenin treatment. Similar to the level of autophagy, the expression levels of adenosine monophosphate-activated protein kinase (aMPK) and unc-51 like autophagy activating kinase-1 were downregulated after chronic restraint stress stimulation and, subsequently upregulated following treatment with apigenin. conversely, the levels of mammalian target of rapamycin (mTor) were increased in chronic restraint stress mice and inhibited by apigenin. Collectively, the present findings indicated that apigenin potentially promotes autophagy via the aMPK/mTor pathway and induces antidepressive effects in chronic restraint stress mice.

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“…Fig. 6C and D present the significant effects of treatment on the p-AMPK/aMPK (F (4,21) =17.83, P<0.0001; Fig. 6c) and ulK1-Ser317/ulK1 ratios (F (4,15) =8.596, P=0.0008; Fig.…”

Section: Apigenin Activity Is Mediated Via Ampk/ulk1 Signalingmentioning

confidence: 92%

Section: Tail Suspension Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The antidepressant effects of apigenin are associated with the�promotion of autophagy via the mTOR/AMPK/ULK1 pathway

Zhang

Jiang

et al. 2019

Mol Med Report

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“…The presence of vitamin E by 69.62% (GCMS analysis), the most abundant compound in the extract was found responsible for the neuroprotective behaviour in Euryale ferox petroleum ether extract treated mice. 47 Anti-aging activity A unique assemblage of amino acids in Euryale ferox was reported to have a strong antioxidant property which could remove intermediate free radicals and chain reactions. The leucine to isoleucine ratio, arginine and lysine to proline ratio of raw Euryale ferox were 1.7 and 9.6% respectively.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

A Critical Review on Ethnobotanical and Pharmacological Aspects of Euryale Ferox Salisb.

Mittal¹,

Sharma²,

Mittal³

2020

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Though now its cultivation is confined only to Bihar along with adjacent states i.e. Assam, Orissa and West Bengal. 5 Optimum atmospheric conditions to grow is tropical and subtropical climate, temperature ranging from 20 o C-35 o C, relative humidity between 50%-90% and rainfall between 100 cm-250 cm. 6 The Euryale ferox is a perineal plant, rooted in the soil with leaves that are broad, round and blade-shaped thus remaining afloat on the surface of pond water. The leaf lamina and vascular bundles have many sharp prickles whereas the rhizomes lie deep in the bottom of the pond with the help of dense fleshy roots. At a time, the plant bears 15-20 spongy fruits, ABSTRACT Introduction: One of the relished dry fruits known by the names of Makhana, Phool Makhana, Gorgon Nut and Fox Nut in the Indian continent, Euryale ferox Salisb. (Nymphaeaceae) is the only plant that belongs to Euryale genus. It is found in abundance in Mithila, Darbhanga and Madhubani region of Bihar state. Since ages, in Ayurveda and Chinese practices, it has been used for the treatment of the renal disorder, chronic diarrhoea, excessive leucorrhea and hepatic dysfunctioning. Its bio-active compounds act as antioxidant, antimicrobial, antiischaemic, anti-diabetic, immunomodulatory, anti-melanogenic, anti-cytotoxic. Methods: The information has been collected from various scientific journals, reviews, books, reports and patent databases. Results: This review summarizes the isolated bioactive compounds in different extracts, patented compounds/formulations with pharmacological activities, present in different parts of Euryale ferox Salisb. Hence, it has been used as a remedy for numerous ailments since long and also proves itself as a panacea for humanity.

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“…The species is often considered as an aquatic food due to its high starch content (more than 70%); additionally, in some areas, people prefer Euryale seed to rice for meal because of its low glycemic index [2]. Furthermore, Euryale semen is also a common Chinese traditional medicine whose pharmacological properties including, anti-depression, anti-oxidant, and anti-diabetic action, have been extensively demonstrated by numerous studies [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Small Auxin Up RNAs influence the distribution of indole-3-acetic acid and play a potential role in increasing seed size in Euryale ferox Salisb.

Huang

Bao

Jin

et al. 2020

Preprint

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Abstract Background: Aquatic Euryale ferox Salisb. is an economically important crop in China and India. Unfortunately, low yield limitations seriously hinder market growth. Unveiling the control of seed size is of remarkable importance in improvement of crops. Here, we generated a new hybrid line (HL) with larger seeds by crossing South Gordon Euryale and North Gordon Euryale (WT) which hasn’t been reported before. However, the functional genes and molecular mechanisms controlling the seed size in Euryale ferox Salisb. remain unclear. In this study, we focused on the exploration of candidate regulatory genes participated in regulating seed size by investigating the new hybrid generation. Results: Both concentration and localization of indole-3-acetic acid (IAA) at two growth stages of fruits of WT and HL were detected by LC-MS and immunofluorescence. Although IAA content between the two lines did not differ, IAA distribution was significantly different. To elucidate the mechanism and to seek the key genes underlying this difference, RNA-seq was performed on young fruits at the two selected growth stages, and differentially expressed genes related to the auxin transduction pathway were selected for further analysis. Conclusion: Hybrid Euryale ferox Salisb. expressed significant heterosis, resulting in non-prickly, thin-coated, large seeds, which accounted for the significantly larger yield of HL than that of WT. Our study indicated that Small Auxin Up RNAs (SAURs) -mediated localization of IAA regulates seed size in Euryale ferox Salisb. We found that some SAURs may act as a positive mediator of the auxin transduction pathway, thereby contributing to the observed heterosis.

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Extract of Euryale ferox Salisb exerts antidepressant effects and regulates autophagy through the adenosine monophosphate‐activated protein kinase—UNC‐51‐like kinase 1 pathway

Cited by 33 publications

References 47 publications

The antidepressant effects of apigenin are associated with the�promotion of autophagy via the mTOR/AMPK/ULK1 pathway

The antidepressant effects of apigenin are associated with the�promotion of autophagy via the mTOR/AMPK/ULK1 pathway

A Critical Review on Ethnobotanical and Pharmacological Aspects of Euryale Ferox Salisb.

Small Auxin Up RNAs influence the distribution of indole-3-acetic acid and play a potential role in increasing seed size in Euryale ferox Salisb.

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