“…Various methods and substances to improve lung graft preservation during cold ischemia, such as pulmonary surfactant, liquid perfluorocarbon (PFC), complement inhibitors, and nitrites, as well as inhalation of hydrogen sulfide or nitric oxide, have been tested experimentally 1 2 However, the standard method of lung graft preservation is still perfusion with a cold low-potassium dextran (LPD) solution via the pulmonary artery (antegrade perfusion) or via the pulmonary veins (retrograde perfusion), together with the use of pulmonary vasodilators and partial inflation of the lungs with oxygen during storage 2 .…”
Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.
“…Various methods and substances to improve lung graft preservation during cold ischemia, such as pulmonary surfactant, liquid perfluorocarbon (PFC), complement inhibitors, and nitrites, as well as inhalation of hydrogen sulfide or nitric oxide, have been tested experimentally 1 2 However, the standard method of lung graft preservation is still perfusion with a cold low-potassium dextran (LPD) solution via the pulmonary artery (antegrade perfusion) or via the pulmonary veins (retrograde perfusion), together with the use of pulmonary vasodilators and partial inflation of the lungs with oxygen during storage 2 .…”
Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia.
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