2017
DOI: 10.1111/exd.13402
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Ultraviolet radiation and skin mast cells: Effects, mechanisms and relevance for skin diseases

Abstract: Mast cells (MCs) are well known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on non-activated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effe… Show more

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Cited by 25 publications
(26 citation statements)
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References 112 publications
(134 reference statements)
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“…It is reported that mast cells can be directly or indirectly affected by UV radiation (75)(76)(77). Our study contributes to the field by showing that the number of histochemically detectable perifollicular mast cells is decreased while their degranulation is increased 1 day after irradiation of the skin surface with UVA and UVB.…”
Section: Discussionsupporting
confidence: 51%
See 1 more Smart Citation
“…It is reported that mast cells can be directly or indirectly affected by UV radiation (75)(76)(77). Our study contributes to the field by showing that the number of histochemically detectable perifollicular mast cells is decreased while their degranulation is increased 1 day after irradiation of the skin surface with UVA and UVB.…”
Section: Discussionsupporting
confidence: 51%
“…Mast cells are important regulators of hair growth and may be functionally important for the maintenance of human HF immune privilege and HF responses to oxidative damage . It has been shown that mast cells are highly affected by UVR , and that UVR or psoralen plus UVA therapy can be beneficial for patients affected by mast cell‐driven skin disorders . Therefore, we were particularly interested in how low or high UVR modulates perifollicular mast cell activities, i.e.…”
Section: Resultsmentioning
confidence: 99%
“…Mast cells contribute to immune responses and modulate inflammation [15]. UV activates skin mast cells and induces release of histamine [43] and increases skin mast cells after 3-4 h [44]. LPS also increases mast cells in the connective tissue of mammals [15].…”
Section: Uvmentioning
confidence: 99%
“…Following the onset of hyperplasia, UVB can induce an inflammatory response [ 27 ]—more specifically, the infiltration of inflammatory mast cells. Mast cells release soluble mediators (i.e., IL-10, TNF-α and VEGF) and are known to participate in tissue remodeling, repair, and wound healing [ 28 , 29 ]. We observed significant increases in mast cell infiltration in all UVB-treated groups, with trending reductions in the 5% GP groups from UVB control mice ( Figure 1 c).…”
Section: Resultsmentioning
confidence: 99%