Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice

Abstract

<jats:p>Non-melanoma skin cancers (NMSCs) are the most diagnosed cancers in the US and occur more frequently in males. We previously demonstrated chemoprotective effects of dietary grape powder (GP) against UVB-mediated skin tumorigenesis in female SKH-1 mice. To expand on this, here, we determined the effects of GP in a short-term UVB exposure protocol (0 or 5% GP, followed by UVB every other day for 2 weeks) in male and female SKH-1 mice, as well as explored any sex-related differences in UVB carcinogenesis via male SKH-1 mice (0, 3, or 5% GP; UVB twice weekly for 28 weeks). In the short-term study, we found that GP protects against early-stage epithelial hyperplasia and mast cell infiltration in both sexes. In the long term, GP markedly reduced tumor counts and malignant conversion, along with significant decreases in mast cell infiltration, serum IgE and Eotaxin. We also found inhibition of P38 phosphorylation and reduced PCNA, Ki67 and BCL2 levels, suggesting that the anti-inflammatory effects of GP inhibits P38, acting as an upstream regulator to inhibit proliferation and reduce tumor cell survival. Together, GP appears to protect against UVB-mediated skin damage and carcinogenesis in SKH-1 mice and should be explored further as a supplement for NMSC prevention.</jats:p>

Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis

“…The presently available treatment does not result in a complete cure as the recurrence rate of this cancer is high, impacting the health budget 10 . Therefore, there is a need to develop newer and effective therapies to prevent this disease 10 . Our results demonstrate a novel role of β 2 ADR in regulating the development and progression of UVB‐induced premalignant cutaneous lesions and the efficacy of selective β 2 ADR antagonists for their treatment.…”

“…Squamous cell carcinoma of the skin is commonly seen globally, and UVB radiation increases the risk of this malignant tumor 8–10 . The presently available treatment does not result in a complete cure as the recurrence rate of this cancer is high, impacting the health budget 10 . Therefore, there is a need to develop newer and effective therapies to prevent this disease 10 .…”

“…Ultraviolet radiation is considered a major risk factor for squamous cell carcinoma of the skin 8–10 . UVB component of ultraviolet radiation is a complete carcinogen capable of cancer initiation, promotion, and progression 9 .…”

Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D2 Receptors

“…Nonmelanoma skin cancer, which includes squamous cell carcinoma (SCC) of the skin, is commonly seen in the world and ultraviolet radiation, particularly its UVB component, increases cancer risk (26)(27)(28). The currently available treatment often does not give a complete cure, as the recurrence rate is high, causing a significant burden to the economy (29,30).…”

Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

“…PCa incidence increases with age, which makes it more difficult to manage this disease. Recent studies demonstrating the beneficial effect of modifying dietary habits have been suggested to manage multiple diseases, including PCa [ 3 , 62 , 63 ]. Here, we found that dietary supplementation with the grape antioxidants quercetin and resveratrol together had significant antitumor effects against PCa in both prevention and intervention settings.…”