Ultraviolet exposure and risk of melanoma and basal cell carcinoma in Ulm and Dresden, Germany

Kaskel, Peter; Lange, Ulrike; Sander, Silvia; Huber, Margit A.; Utikal, Jochen; Leiter, Ulrike; Krähn, Gertraud; Meurer, Michael; Kron, Martina

doi:10.1111/jdv.12488

Cited by 31 publications

(30 citation statements)

References 52 publications

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“…The increased attributable risk to skin cancer does not only concern melanoma but also squamous cell carcinoma (SCC): A recent study has found a relative risk of 1.9, which means a 90% increased risk for SCC in sunbed users. Moreover, sunbed use was also shown to be a risk factor (among others) for sporadic basal cell carcinoma (BCC) in Germany …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, sunbed use was also shown to be a risk factor (among others) for sporadic basal cell carcinoma (BCC) in Germany. 10 Accordingly, awareness campaigns have been launched to inform the public about the risk of sunbed use, and in some countries there has been a ban for children and young adults to visit commercial sunbeds, 11 including Belgium, The Netherlands, Finland, France, Germany, Spain, Iceland, Norway, Ireland and Lithuania. A total ban for sunbeds have been imposed in Australia since 2015, as in Brazil where such a ban was executed in 2009 already.…”

Section: Introductionmentioning

confidence: 99%

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Decreasing sunbed use in the German population between 2001 and 2015: survey in 155 679 working persons

Augustin

Schäfer

Reusch

et al. 2019

Acad Dermatol Venereol

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Background UV radiation is a proven cause of skin cancer. Use of sunbeds has been shown to provide an attributable risk. Objective To evaluate the proportion of regular sunbed use in Germany based on large‐scale population‐based surveys over 15 years. Methods Skin cancer screenings by dermatologists were conducted between 2001 and 2015 in more than 500 German companies, including a clinical examination and interviews on the risk behaviour related to sunburns and sunbeds. Results Among 155 679 persons included regular sunbed use significantly declined from 11.0% in 2001 to 1.6% in 2015 (P < 0.001). There were significantly higher rates of sunbed use in women (12.5%/2.0%) vs. men (7.3%/1.3%; P < 0.001), in younger persons and in participants with darker skin (type II and III) vs. fair skin (type I). Individuals with sunburns in childhood were significantly more often sunbed users (5.1% vs. 4.6%; P = 0.002). A remarkable decline of sunbed use was observed after 2009 (7.0% in 2001–2008 and 2.2% in 2009–2015). This reduction occurred in the time of a legal ban of sunbed use for minors but also with the start of the national skin cancer screening programme. Conclusion Use of sunbeds in the German adult population has dropped by more than 85% in the past decade. Primary prevention, including the large public awareness following the legal ban of sunbed use for young people and the effects of the statutory skin cancer screening programme may have contributed to this.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Decreasing sunbed use in the German population between 2001 and 2015: survey in 155 679 working persons

Augustin

Schäfer

Reusch

et al. 2019

Acad Dermatol Venereol

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“…The relationship between atopy and carcinoma of the skin has been examined by several studies, with divergent results. [1][2][3][4][5][6] In the scientific literature, two underlying major concepts are discussed. The first cites allergies as a stimulant of the immune system and protective factor with respect to the development of carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings

Schäfer

Mohr

Zander

et al. 2017

Acad Dermatol Venereol

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Design limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross-sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population-based cohort afford valuable insights into the relationship between atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.

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“…[19][20][21][22][23] Fair skin, red or blond hair, and light eye color are associated with BCC as independent risk factors due to greater susceptibility to UV damage. 21,[23][24][25][26][27][28][29] BCC risk is increased by both UV-A and -B radiation as well as by ionizing radiation. Radiation treatment for other conditions, especially at a young age, is also associated with an increased risk for developing BCC.…”

mentioning

confidence: 99%

Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Bichakjian

Olencki

Aasi

et al. 2016

J Natl Compr Canc Netw

238

235

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Basal cell carcinoma (BCC) of the skin is the most common cancer, with a higher incidence than all other malignancies combined. Although it is rare to metastasize, patients with multiple or frequently recurring BCC can suffer substantial comorbidity and be difficult to manage. Assessment of risk is a key element of management needed to inform treatment selection. The overall management of BCC primarily consists of surgical approaches, with radiation therapy as an alternate or adjuvant option. Many superficial therapies for BCC have been explored and continue to be developed, including topicals, cryosurgery, and photodynamic therapy. Two hedgehog pathway inhibitors were recently approved by the FDA for systemic treatment of advanced and metastatic BCC, and others are in development. The NCCN Guidelines for Basal Cell Skin Cancer, published in full herein, include recommendations for selecting among the various surgical approaches based on patient-, lesion-, and disease-specific factors, as well as guidance on when to use radiation therapy, superficial therapies, and hedgehog pathway inhibitors.

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Ultraviolet exposure and risk of melanoma and basal cell carcinoma in Ulm and Dresden, Germany

Cited by 31 publications

References 52 publications

Decreasing sunbed use in the German population between 2001 and 2015: survey in 155 679 working persons

Decreasing sunbed use in the German population between 2001 and 2015: survey in 155 679 working persons

Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings

Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

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