Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings

Schäfer, Ines; Mohr, Peter; Zander, Nicole E.; Fölster‐Holst, Regina; Augustin, Matthias

doi:10.1111/jdv.14456

Cited by 13 publications

(26 citation statements)

References 23 publications

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“…This assessment was applied as the overall clinical impression of all body sites. Atopic disposition was defined as discussed previously as pre‐existing conditions of pollen, house dust mite or animal hair allergy or atopic eczema …”

Section: Methodsmentioning

confidence: 99%

Prevalence, predictors and comorbidity of dry skin in the general population

Augustin

Kirsten

Körber³

et al. 2018

Acad Dermatol Venereol

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Section: Methodsmentioning

confidence: 99%

Prevalence, predictors and comorbidity of dry skin in the general population

Augustin

Kirsten

Körber³

et al. 2018

Acad Dermatol Venereol

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“…20 publications on the prevalence of MM were included, both registry studies and primary data compilations [10-17, 19, 21, 24-29, 31, 32, 34, 35]. Prevalence rates of MM were analyzed in several studies and showed varying sex-specific differences (Table 3) [11][12][13]27]. Augustin et al also reported higher one-year prevalences in urban regions as compared with rural areas.…”

Section: Malignant Melanomamentioning

confidence: 99%

“…Eleven publications on the epidemiology of NMSC were included [9, 11-14, 16, 20, 22, 26, 28, 29]. The sex-specific prevalences for NMSC as well as for basal cell carcinoma (BCC) showed a preponderance of male patients (Table 3) [11][12][13]. Incidence rates of squamous cell carcinoma (SCC) were generally lower than those of BCC [26,28,29].…”

Section: Non-melanoma Skin Cancermentioning

confidence: 99%

Epidemiology of skin diseases in Germany: systematic review of the current state of research – part 1: cutaneous tumor diseases

Hansen

Augustin

Schäfer

et al. 2022

J Deutsche Derma Gesell

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SummaryEpidemiological data are of great importance for the identification of health care needs, the detection of gaps in care, the development of targeted prevention measures, and for the optimization of resource allocation. The aim of this work was to systematically collect all previously published population‐based epidemiological data on skin diseases in Germany. The present part 1 of the publication series deals with tumor diseases of the skin. The results on non‐infectious (part 2) and infectious skin diseases (part 3) form the other parts of this publication series.A systematic search of the literature spanning the last 15 years was conducted using the PubMed/MEDLINE database. With the aim of including all dermatologic diseases, a diagnostic list was developed based on the ICD‐11 catalogue. This list included 1,347 skin diseases and formed the basis for the search. The literature search yielded 4,650 publications. After two‐stage screening, 72 studies on 43 different skin diseases were included in the synthesis. Among them were 30 publications on cutaneous tumor diseases, the majority was related to malignant melanoma.This work is the first systematic literature review that aimed to report all available epidemiological data on skin diseases in Germany. In terms of study characteristics, a high heterogeneity was found for the different skin diseases. Even though the methodology of the included epidemiological studies varied considerably, the usefulness of these epidemiological data is extremely wide‐ranging. Thus, this work can serve as a reference for various epidemiological questions.

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“…Another possible confounding factor not addressed in the study of Thyssen et al (2018) is the presence of AD, which is more prevalent in the carriers of FLG mutations. In a recent cross-sectional study of Sch€ afer et al, 5 atopic diseases showed significantly protective against MM. Clearly, there are several pathways by which filaggrin may modify the risk for MM; however, the overall effect of FLG mutations is difficult to assess.…”

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confidence: 90%

Loss‐of‐function mutations in filaggrin gene and malignant melanoma

Kežić

2018

Acad Dermatol Venereol

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Filaggrin, a highly abundant protein of the stratum corneum (SC), draw considerable attention after the discovery of its role in the aetiology of atopic dermatitis (AD). Next to its importance for the skin barrier function, filaggrin is the primary source of trans-urocanic acid (tUCA), a major SC chromophore able to absorb ultraviolet radiation (UVR). 1 Hence, low filaggrin levels might lead to higher internal UVR dose because of reduced skin barrier function as well as decreased absorption of UVR by tUCA. Thyssen et al. 2 hypothesized that the carriers of filaggrin gene (FLG) mutations might be more prone to develop malignant melanoma (MM), the deadliest form of skin cancer strongly linked with exposure to UVR. An earlier study showed an increased prevalence of actinic keratosis (AK) and squamous cell carcinoma (SCC) in homozygous FLG mutation carriers compared to controls. 3 However, in the present casecontrol study, no association between FLG mutation and MM risk could be detected, in accordance with the results from the population-based study conducted by the same research group. 3 Several reasons might explain these findings. The immune system plays a critical role in modulating and controlling the tumour progression in MM. One of important UVR effects is immunosuppression, and paradoxically, the same effect has also been shown for the photo product of tUCA, cis-urocanic acid (cUCA). Obviously, the effect of reduced filaggrin levels (i.e. tUCA) can work in opposing directions of magnitudes which are difficult to estimate. Another factor that should be considered when comparing AK and SCC with MM is their specific dose-effect pattern. While AK and SCC are largely dependent on the cumulative dose, intermittent high UVR exposure is more strongly linked to MM. 4 Possibly, the high UVR dose causing sunburns might outweigh relatively modest (protecting) effect of tUCA. Another possible confounding factor not addressed in the study of Thyssen et al. (2018) is the presence of AD, which is more prevalent in the carriers of FLG mutations. In a recent cross-sectional study of Sch€ afer et al., 5 atopic diseases showed significantly protective against MM. Clearly, there are several pathways by which filaggrin may modify the risk for MM; however, the overall effect of FLG mutations is difficult to assess. References1 Thyssen JP, Kezic S. Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol 2014; 134: 792-799. 2 Thyssen JP, Andersen YMF, Balslev E et al. Loss-of-function mutations in filaggrin gene and malignant melanoma: a case-control study. J Eur Acad Dermatol Venereol 2018; 32: 242-244. 3 Skaaby T, Husemoen LLN, Thyssen JP et al. Filaggrin loss-of-function mutations and incident cancer: a population-based study. Br J Dermatol 2014; 171: 1407-1414. 4 Gilchrest BA, Eller MS, Geller AC, Yaar M. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 1999; 340: 1341-1348. 5 Sch€ afer I, Mohr P, Zander N, F€ olster-Holst R, Augustin M. A...

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Association of atopy and tentative diagnosis of skin cancer – results from occupational skin cancer screenings

Cited by 13 publications

References 23 publications

Prevalence, predictors and comorbidity of dry skin in the general population

Prevalence, predictors and comorbidity of dry skin in the general population

Epidemiology of skin diseases in Germany: systematic review of the current state of research – part 1: cutaneous tumor diseases

Loss‐of‐function mutations in filaggrin gene and malignant melanoma

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