Ultratrace antibiotic sensing using aptamer/graphene-based field-effect transistors

Chen, Xiaoyan; Liu, Ying; Fang, Xian; Li, Zhuo; Pu, Haihui; Chang, Jingbo; Chen, Junhong; Mao, Shun

doi:10.1016/j.bios.2018.11.034

Cited by 88 publications

(56 citation statements)

References 35 publications

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“…49−51 Recent graphene FET sensors for chemical sensing (including nitrate ions) have been explored with a better output. 52−54 Chen et al reported a label-free micropatterned rGO film FET sensor that can detect selectively Cd 2+ and Hg 2+ ions in a real-time fashion. 55 Ikhsan et al reported a facile synthesis of a graphene oxide–silver nanocomposite and its modified electrode for enhanced electrochemical detection of nitrite ions.…”

Section: Introductionmentioning

confidence: 99%

Nozzle-Jet-Printed Silver/Graphene Composite-Based Field-Effect Transistor Sensor for Phosphate Ion Detection

et al. 2019

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High concentration of dissolved phosphate ions is the main responsible factor for eutrophication of natural water bodies. Therefore, detection of phosphate ions is essential for evaluating water eutrophication. There is a need at large-scale production of real-time monitoring technology to detect phosphorus accurately. In this study, facile enzymeless phosphate ion detection is reported using a nozzle-jet-printed silver/reduced graphene oxide (Ag/rGO) composite-based field-effect transistor sensor on flexible and disposable polymer substrates. The sensor exhibits promising results in low concentration as well as real-time phosphate ion detection. The sensor shows excellent performance with a wide linear range of 0.005–6.00 mM, high sensitivity of 62.2 μA/cm 2 /mM, and low detection limit of 0.2 μM. This facile combined technology readily facilitates the phosphate ion detection with high performance, long-term stability, excellent reproducibility, and good selectivity in the presence of other interfering anions. The sensor fabrication method and phosphate detection technique yield low-cost, user-friendly sensing devices with less analyte consumption, which are easy to fabricate on polymer substrates on a large scale. Besides, the sensor has the capability to sense phosphate ions in real water samples, which makes it applicable in environmental monitoring.

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Section: Introductionmentioning

confidence: 99%

Nozzle-Jet-Printed Silver/Graphene Composite-Based Field-Effect Transistor Sensor for Phosphate Ion Detection

et al. 2019

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“…38,39 They have also been shown to detect multiple biologically-relevant molecules such as glucose, 40 various biomarkers for diseases including cancer, 41,42 DNA sequences with single-nucleotide mismatch specificity, 43,44 pathogens such as bacteria 45,46 and viruses, 47,48 or drugs like opioids 49 or antibiotics. 50 GFETs are often described as having key advantages for biosensing applications, including easy operation, fast response, 51 real-time monitoring, [52][53][54] high specificity and sensitivity with detection limits down to the femtomolar 55,56 and sub-femtomolar range, [57][58][59] microfluidic integration [60][61][62] and multiplexing capability. [63][64][65] In recent years, there has been several reviews discussing the latest research on graphene and its applications as biosensors.…”

Section: Anouk Béraudmentioning

confidence: 99%

“…90 The two most common cell designs used with GFET biosensors are the open cell and the flow cell: the first one consists of a simple top-open reservoir in which samples can be pipetted in and out. 40,42,54,88,105,109,115,129 Flow cells generally consist of a small enclosed channel with tubing for sample inlet and outlet, 50,53,61,63,64,130 allowing minimized evaporation and mixing between samples, lower sample volumes (few μL) as well as controlled fluid flow. This minimizes the consumption of reagents and samples, and lessens signal perturbations such as commonly observed during the loading/emptying of open cells.…”

Section: Analyte Media and Deliverymentioning

confidence: 99%

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance

Béraud

Sauvage

Bazán

et al. 2021

Analyst

128

161

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“…Currently, methods for detecting antibiotics in water include high‐performance liquid chromatographic (HPLC), [ 8 ] liquid chromatography–tandem mass spectrometry (LC–MS), [ 9 ] Raman spectroscopy (RS), [ 10 ] and ion mobility spectroscopy (IMS), [ 11 ] field‐effect transistor, [ 12 ] paper‐based microfluidics [ 13 ] and electrochemical biosensor [ 14 ] are methods reported in recent years. However, these methods require not only expensive equipment, but also rigorous testing conditions.…”

Section: Introductionmentioning

confidence: 99%

Highly Selective and Stable Zn (II)‐Based Metal–Organic Frameworks for the Detections of Tetracycline Antibiotic and Acetone in Aqueous System

Zhu

Zong

Zhang

et al. 2020

Applied Organom Chemis

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Tetracycline (TC) is one of the most widely used antibiotics in aquaculture, and its good water solubility makes it a major contaminant in seawater. Therefore, it is very necessary and challenging to develop an efficient detection method. In this work, two novel metal–organic frameworks [Zn (bpydb)(bimmb)0.5]n (1), {[Zn2(bpydb)2(bimb)]·[Zn (bpydb)(bimb)]·H2O}n (2), (bimb = 1,4‐bis (lmidazol) butane, H2bypdb = 4,4′‐(4,4’‐Bipyridine‐2,6‐diyl)dibenzoic acid, bimmb = 1,4‐bis (imidazol‐1‐ylmethyl)benzene) were successfully synthesized under solvothermal conditions. Zn‐MOF 1–2 were characterized by X‐ray powder diffraction (PXRD), Fourier transform infrared (FT‐IR) spectroscopy and thermogravimetric analysis (TGA). As expected, 1–2 have excellent fluorescence properties, thermal stability and good structural stability in water. TC in water can be detected by fluorescence quenching with high selectivity. At the same time, the fluorescence quenching efficiency remains unchanged in the presence of other interfering antibiotics and in aqueous solutions of different pH values (pH = 3–10). The detection ability of 1 in real seawater has not changed substantially, showing considerable practical application prospects. Interestingly, 1–2 also efficiently detected traces of acetone in solution with detection limits of 0.07 μM (4.38 ppb) and 0.18 μM (10.85 ppb), respectively. In addition, the mechanism of fluorescence quenching is further discussed.

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Ultratrace antibiotic sensing using aptamer/graphene-based field-effect transistors

Cited by 88 publications

References 35 publications

Nozzle-Jet-Printed Silver/Graphene Composite-Based Field-Effect Transistor Sensor for Phosphate Ion Detection

Nozzle-Jet-Printed Silver/Graphene Composite-Based Field-Effect Transistor Sensor for Phosphate Ion Detection

Graphene field-effect transistors as bioanalytical sensors: design, operation and performance

Highly Selective and Stable Zn (II)‐Based Metal–Organic Frameworks for the Detections of Tetracycline Antibiotic and Acetone in Aqueous System

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