All-oxide magnetic tunnel junctions with a semiconducting barrier, formed by the half-metallic ferromagnet La 0.7 Sr 0.3 MnO 3 and n-type semiconductor SrTi 0.8 Nb 0.2 O 3 , were designed, fabricated, and investigated in terms of their magneto-transport properties as a function of applied bias and temperature. We found that the use of the heavily Nb-doped SrTiO 3 as a barrier results in significant improvement in the reproducibility of results, i.e., of large tunnel magnetoresistance (TMR) ratios, and a spectral noise density reduced by three orders of magnitude at low temperature. We attribute this finding to a considerably decreased amount of point defects in SrTi 0.8 Nb 0.2 O 3 , especially oxygen vacancies, compared with the conventional insulating SrTiO 3 barrier.